دورية أكاديمية
Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging.
| العنوان: | Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging. |
|---|---|
| المؤلفون: | Bogeska R; Division of Experimental Hematology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany., Mikecin AM; Division of Experimental Hematology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany., Kaschutnig P; Division of Experimental Hematology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany; Faculty of Biosciences, University of Heidelberg, 69120 Heidelberg, Germany., Fawaz M; Department of Medicine, Hematology/Oncology, Goethe University Hospital Frankfurt, 60590 Frankfurt, Germany., Büchler-Schäff M; Division of Experimental Hematology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany; Faculty of Biosciences, University of Heidelberg, 69120 Heidelberg, Germany., Le D; Program in Immunology, Graduate School of Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA., Ganuza M; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London London EC1M 6BQ, UK., Vollmer A; Institute of Molecular Medicine, Stem Cells and Aging, Aging Research Center, Ulm University, 89081 Ulm, Germany., Paffenholz SV; Division of Experimental Hematology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany; Faculty of Biosciences, University of Heidelberg, 69120 Heidelberg, Germany., Asada N; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Rodriguez-Correa E; Division of Experimental Hematology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany; Faculty of Biosciences, University of Heidelberg, 69120 Heidelberg, Germany., Frauhammer F; Faculty of Biosciences, University of Heidelberg, 69120 Heidelberg, Germany; Division of Applied Bioinformatics, DKFZ, 69120 Heidelberg, Germany., Buettner F; Department of Medicine, Hematology/Oncology, Goethe University Hospital Frankfurt, 60590 Frankfurt, Germany; The German Cancer Consortium (DKTK), 69120 Heidelberg, Germany; Frankfurt Cancer Institute, 60590 Frankfurt, Germany., Ball M; Division of Experimental Hematology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany., Knoch J; Division of Experimental Hematology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany., Stäble S; Division of Experimental Hematology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany; Faculty of Biosciences, University of Heidelberg, 69120 Heidelberg, Germany; Section Translational Cancer Epigenomics, Division of Translational Medical Oncology, DKFZ, 69120 Heidelberg, Germany., Walter D; Division of Experimental Hematology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany., Petri A; Division of Experimental Hematology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany., Carreño-Gonzalez MJ; Division of Experimental Hematology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany; Faculty of Biosciences, University of Heidelberg, 69120 Heidelberg, Germany., Wagner V; Division of Experimental Hematology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany; Faculty of Biosciences, University of Heidelberg, 69120 Heidelberg, Germany., Brors B; Division of Applied Bioinformatics, DKFZ, 69120 Heidelberg, Germany., Haas S; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany; The German Cancer Consortium (DKTK), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, DKFZ, 69120 Heidelberg, Germany; DKFZ-ZMBH Alliance, Heidelberg, Germany; Berlin Institute of Health (BIH), Charité Universitätsmedizin, 10178 Berlin, Germany; Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany., Lipka DB; The German Cancer Consortium (DKTK), 69120 Heidelberg, Germany; Section Translational Cancer Epigenomics, Division of Translational Medical Oncology, DKFZ, 69120 Heidelberg, Germany; National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany; Faculty of Medicine, Otto-von-Guericke University, 39120 Magdeburg, Germany., Essers MAG; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany; DKFZ-ZMBH Alliance, Heidelberg, Germany; Division of Inflammatory Stress in Stem Cells, DKFZ, 69120 Heidelberg, Germany., Weru V; Division of Biostatistics, DKFZ, 69120 Heidelberg, Germany., Holland-Letz T; Division of Biostatistics, DKFZ, 69120 Heidelberg, Germany., Mallm JP; Division of Chromatin Networks, DKFZ, 69120 Heidelberg, Germany., Rippe K; Division of Chromatin Networks, DKFZ, 69120 Heidelberg, Germany., Krämer S; Faculty of Biosciences, University of Heidelberg, 69120 Heidelberg, Germany; Section Translational Cancer Epigenomics, Division of Translational Medical Oncology, DKFZ, 69120 Heidelberg, Germany; Biomedical Informatics, Data Mining and Data Analytics, Faculty of Applied Computer Science and Medical Faculty, University of Augsburg, 86159 Augsburg, Germany; Bioinformatics and Omics Data Analysis, DKFZ, 69120 Heidelberg, Germany., Schlesner M; Biomedical Informatics, Data Mining and Data Analytics, Faculty of Applied Computer Science and Medical Faculty, University of Augsburg, 86159 Augsburg, Germany; Bioinformatics and Omics Data Analysis, DKFZ, 69120 Heidelberg, Germany., McKinney Freeman S; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Florian MC; Stem Cell Aging Group, Regenerative Medicine Program, The Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain., King KY; Program in Immunology, Graduate School of Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, TX 77030, USA., Frenette PS; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Rieger MA; Department of Medicine, Hematology/Oncology, Goethe University Hospital Frankfurt, 60590 Frankfurt, Germany; The German Cancer Consortium (DKTK), 69120 Heidelberg, Germany; Frankfurt Cancer Institute, 60590 Frankfurt, Germany; Cardio-Pulmonary Institute, 60590 Frankfurt, Germany., Milsom MD; Division of Experimental Hematology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany; DKFZ-ZMBH Alliance, Heidelberg, Germany. Electronic address: michael.milsom@dkfz.de. |
| المصدر: | Cell stem cell [Cell Stem Cell] 2022 Aug 04; Vol. 29 (8), pp. 1273-1284.e8. Date of Electronic Publication: 2022 Jul 19. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, MA : Cell Press |
| مواضيع طبية MeSH: | Hematopoiesis* , Hematopoietic Stem Cells*, Aged ; Aging ; Animals ; Bone Marrow ; Humans ; Inflammation ; Mice |
| مستخلص: | Hematopoietic stem cells (HSCs) mediate regeneration of the hematopoietic system following injury, such as following infection or inflammation. These challenges impair HSC function, but whether this functional impairment extends beyond the duration of inflammatory exposure is unknown. Unexpectedly, we observed an irreversible depletion of functional HSCs following challenge with inflammation or bacterial infection, with no evidence of any recovery up to 1 year afterward. HSCs from challenged mice demonstrated multiple cellular and molecular features of accelerated aging and developed clinically relevant blood and bone marrow phenotypes not normally observed in aged laboratory mice but commonly seen in elderly humans. In vivo HSC self-renewal divisions were absent or extremely rare during both challenge and recovery periods. The progressive, irreversible attrition of HSC function demonstrates that temporally discrete inflammatory events elicit a cumulative inhibitory effect on HSCs. This work positions early/mid-life inflammation as a mediator of lifelong defects in tissue maintenance and regeneration. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment in: Cell Stem Cell. 2022 Aug 4;29(8):1156-1158. (PMID: 35931026) |
| References: | Cell. 2008 Dec 12;135(6):1118-29. (PMID: 19062086) Science. 2004 Jan 16;303(5656):359-63. (PMID: 14671312) Cell Stem Cell. 2017 Aug 3;21(2):225-240.e5. (PMID: 28736216) Exp Hematol. 2020 Mar;83:66-73. (PMID: 31893524) Nat Protoc. 2013 Oct;8(10):2022-32. (PMID: 24071908) Cell Stem Cell. 2021 Aug 5;28(8):1428-1442.e6. (PMID: 33743191) Bioinformatics. 2009 Aug 15;25(16):2078-9. (PMID: 19505943) Nat Cell Biol. 2019 Nov;21(11):1309-1320. (PMID: 31685996) J Immunol. 2011 May 1;186(9):5367-75. (PMID: 21441445) J Clin Microbiol. 2000 Nov;38(11):4080-5. (PMID: 11060072) Bioinformatics. 2016 Apr 15;32(8):1241-3. (PMID: 26668002) Aging Cell. 2021 Jun;20(6):e13366. (PMID: 34050697) Cell Stem Cell. 2015 Oct 1;17(4):422-34. (PMID: 26299573) Semin Immunol. 2018 Dec;40:17-35. (PMID: 30287177) J Immunol Methods. 2009 Aug 15;347(1-2):70-8. (PMID: 19567251) Blood. 2019 May 2;133(18):1927-1942. (PMID: 30782612) Nat Rev Genet. 2018 Jun;19(6):371-384. (PMID: 29643443) Nat Cell Biol. 2022 May;24(5):697-707. (PMID: 35513711) J Biotechnol. 2017 Nov 10;261:53-62. (PMID: 28803971) Nature. 1976 Nov 4;264(5581):68-9. (PMID: 1004539) Cell. 2013 Jun 6;153(6):1194-217. (PMID: 23746838) J Exp Med. 2021 Jul 5;218(7):. (PMID: 34129017) Blood. 2004 Oct 15;104(8):2263-8. (PMID: 15238427) Nat Rev Immunol. 2011 Sep 09;11(10):685-92. (PMID: 21904387) Cell. 2017 May 18;169(5):807-823.e19. (PMID: 28479188) Antimicrob Agents Chemother. 2015 Apr;59(4):2129-35. (PMID: 25624335) Cell Stem Cell. 2013 Apr 4;12(4):413-25. (PMID: 23415915) Nature. 2009 Apr 16;458(7240):904-8. (PMID: 19212321) Bioinformatics. 2014 Aug 1;30(15):2114-20. (PMID: 24695404) Genome Biol. 2014;15(12):550. (PMID: 25516281) Nat Methods. 2017 May;14(5):483-486. (PMID: 28346451) PLoS One. 2013;8(1):e54289. (PMID: 23382888) Nat Cell Biol. 2016 Jun;18(6):607-18. (PMID: 27111842) Science. 2009 Jul 10;325(5937):217-8. (PMID: 19590005) Cell Rep. 2016 Dec 6;17(10):2584-2595. (PMID: 27926863) J Exp Med. 2021 Jul 5;218(7):. (PMID: 34129016) Am J Clin Pathol. 1965 Apr;43:326-31. (PMID: 14275849) Nat Methods. 2013 Nov;10(11):1093-5. (PMID: 24056876) Sci Adv. 2021 Dec 10;7(50):eabk3521. (PMID: 34890222) Nature. 2013 Oct 31;502(7473):637-43. (PMID: 24107994) Lancet. 1965 Aug 28;2(7409):418-9. (PMID: 14348601) J Exp Med. 2011 Feb 14;208(2):273-84. (PMID: 21300914) Nat Commun. 2015 Nov 25;6:8928. (PMID: 26603207) Cell Stem Cell. 2020 Mar 5;26(3):420-430.e6. (PMID: 32059807) Blood. 2006 Sep 1;108(5):1533-41. (PMID: 16675709) Hum Mol Genet. 2020 Oct 20;29(R2):R248-R254. (PMID: 32821941) J Anat. 2011 Nov;219(5):574-81. (PMID: 21923862) Nature. 2010 Jun 10;465(7299):793-7. (PMID: 20535209) Cell Stem Cell. 2022 May 5;29(5):760-775.e10. (PMID: 35523139) Bioinformatics. 2013 Jan 1;29(1):15-21. (PMID: 23104886) Cell Stem Cell. 2008 Jan 10;2(1):83-9. (PMID: 18371424) Nature. 2015 Apr 23;520(7548):549-52. (PMID: 25707806) Elife. 2018 Nov 14;7:. (PMID: 30427307) Blood. 2016 Aug 25;128(8):e20-31. (PMID: 27365425) Curr Stem Cell Rep. 2020;6(3):96-107. (PMID: 32837857) Front Immunol. 2016 Nov 07;7:487. (PMID: 27872627) |
| معلومات مُعتمدة: | F31 HL154661 United States HL NHLBI NIH HHS; R01 DK112976 United States DK NIDDK NIH HHS; R35 HL155672 United States HL NHLBI NIH HHS; P30 ES030285 United States ES NIEHS NIH HHS; R01 DK056638 United States DK NIDDK NIH HHS |
| فهرسة مساهمة: | Keywords: HSCs; accelerated aging; aging; clonal hematopoiesis; hematopoietic stem cells; inflammaging; inflammation; self-renewal; stem cell exhaustion; stress hematopoiesis |
| تواريخ الأحداث: | Date Created: 20220720 Date Completed: 20220809 Latest Revision: 20230805 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9357150 |
| DOI: | 10.1016/j.stem.2022.06.012 |
| PMID: | 35858618 |
| قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!