دورية أكاديمية
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Fingolimod attenuates gait deficits in mice subjected to experimental autoimmune encephalomyelitis.

التفاصيل البيبلوغرافية
العنوان: Fingolimod attenuates gait deficits in mice subjected to experimental autoimmune encephalomyelitis.
المؤلفون: Kasheke GDS; Department of Pharmacology, Brain Repair Centre, Faculty of Medicine, Life Sciences Research Institute, 2nd floor 1348 Summer Street, P.O. Box 15000, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada. Electronic address: Gracious.Kasheke@dal.ca., Holman SP; Department of Pharmacology, Brain Repair Centre, Faculty of Medicine, Life Sciences Research Institute, 2nd floor 1348 Summer Street, P.O. Box 15000, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada., Robertson GS; Department of Pharmacology, Brain Repair Centre, Faculty of Medicine, Life Sciences Research Institute, 2nd floor 1348 Summer Street, P.O. Box 15000, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada; Department of Psychiatry, 5909 Veterans' Memorial Lane, 8th floor, Abbie J. Lane Memorial Building, QEII Health Sciences Centre, Halifax, Nova Scotia B3H 2E2, Canada. Electronic address: George.Robertson@dal.ca.
المصدر: Journal of neuroimmunology [J Neuroimmunol] 2022 Sep 15; Vol. 370, pp. 577926. Date of Electronic Publication: 2022 Jul 12.
نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 8109498 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8421 (Electronic) Linking ISSN: 01655728 NLM ISO Abbreviation: J Neuroimmunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier/North-Holland, c1981-
مواضيع طبية MeSH: Encephalomyelitis, Autoimmune, Experimental*/drug therapy , Multiple Sclerosis, Relapsing-Remitting*, Animals ; Fingolimod Hydrochloride/pharmacology ; Fingolimod Hydrochloride/therapeutic use ; Gait ; Mice ; Mice, Inbred C57BL ; Spinal Cord
مستخلص: Fingolimod, used to treat relapsing-remitting multiple sclerosis (RRMS), reduces motor deficits in mice with established experimental autoimmune encephalomyelitis (EAE). To better characterize the therapeutic effects of fingolimod, kinematic gait analysis was employed to precisely measure movements of a hindleg while EAE mice walked on a treadmill. Relative to the vehicle group, oral dosing with fingolimod, beginning after disease onset (1 mg/kg/day), increased hip heights and knee joint movements, and reduced spinal cord demyelination. These findings suggest that fingolimod preserves gait in RRMS patients by protecting motor circuits in the spinal cord.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Experimental autoimmune encephalomyelitis; Fingolimod; Kinematic gait analysis
المشرفين على المادة: G926EC510T (Fingolimod Hydrochloride)
تواريخ الأحداث: Date Created: 20220721 Date Completed: 20220809 Latest Revision: 20221009
رمز التحديث: 20240628
DOI: 10.1016/j.jneuroim.2022.577926
PMID: 35863299
قاعدة البيانات: MEDLINE
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