دورية أكاديمية
Photosensitized and Photothermal Stimulation of Cellular Membranes by Organic Thin Films and Nanoparticles.
| العنوان: | Photosensitized and Photothermal Stimulation of Cellular Membranes by Organic Thin Films and Nanoparticles. |
|---|---|
| المؤلفون: | Feyen PLC; Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genoa, Italy.; DZNE-German Center for Neurodegenerative Diseases, Munich, Germany., Matarèse BFE; Department of Chemistry, Imperial College London, South Kensington Campus, London, United Kingdom.; Department of Physics, University of Cambridge, Cambridge, United Kingdom.; Department of Heamatology, University of Cambridge, Cambridge, United Kingdom., Urbano L; King's College London, Institute of Pharmaceutical Science, London, United Kingdom.; Department of Clinical Pharmaceutical and Biological Sciences, University of Hertfordshire, Hatfield, United Kingdom., Abelha TF; King's College London, Institute of Pharmaceutical Science, London, United Kingdom.; Laboratory of Optics and Photonics, Institute of Physics, Federal University of Mato Grosso do Sul, Campo Grande, Brazil., Rahmoune H; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom., Green M; Department of Physics, King's College London, London, United Kingdom., Dailey LA; Department of Pharmaceutical Technology and Biopharmacy, University of Vienna, Vienna, Austria., de Mello JC; Department of Chemistry, Imperial College London, South Kensington Campus, London, United Kingdom.; Department of Chemistry, Centre for Organic Electronic Materials, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Benfenati F; Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genoa, Italy.; IRCCS Ospedale Policlinico San Martino, Genoa, Italy. |
| المصدر: | Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2022 Jul 07; Vol. 10, pp. 932877. Date of Electronic Publication: 2022 Jul 07 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101632513 Publication Model: eCollection Cited Medium: Print ISSN: 2296-4185 (Print) Linking ISSN: 22964185 NLM ISO Abbreviation: Front Bioeng Biotechnol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media S.A., [2013]- |
| مستخلص: | Conjugated polymers are increasingly exploited for biomedical applications. In this work, we explored the optical characteristics of conjugated polymers of variable chemical structures at multiple levels relevant to biological interfacing, from fluorescence yield to their influence on cellular membrane potential. We systematically compared the performance of conjugated polymer as cast thin films and as nanoparticles stabilized with amphiphilic polyethylene glycol-poly lactic acid-co-glycolic acid (PEG-PLGA). We assessed in both the dark and under illumination the stability of key optoelectronic properties in various environments, including air and biologically relevant physiological saline solutions. We found that photoreduction of oxygen correlates with nanoparticle and film degradation in physiologically relevant media. Using patch-clamp recordings in cell lines and primary neurons, we identified two broad classes of membrane potential response, which correspond to photosensitizer- and photothermal-mediated effects. Last, we introduced a metric named OED Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Feyen, Matarèse, Urbano, Abelha, Rahmoune, Green, Dailey, de Mello and Benfenati.) |
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| فهرسة مساهمة: | Keywords: bioelectronics; conjugated polymers; nanoparticle; photosensitizer; photothermal; reactive oxygen species; solid state–aqueous interphase; thin-film |
| تواريخ الأحداث: | Date Created: 20220725 Latest Revision: 20220726 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC9302485 |
| DOI: | 10.3389/fbioe.2022.932877 |
| PMID: | 35875499 |
| قاعدة البيانات: | MEDLINE |
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