دورية أكاديمية
Age-volume associations in cerebellar lobules by sex and reproductive stage.
| العنوان: | Age-volume associations in cerebellar lobules by sex and reproductive stage. |
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| المؤلفون: | Hicks TH; Department of Psychological and Brain Sciences, Texas A&M University, 4235 TAMU, College Station, TX, 77840, USA. tslonim@tamu.edu., Ballard HK; Texas A&M University Institute for Neuroscience, 3474 TAMU, College Station, TX, 77843, USA., Sang H; Department of Statistics, Texas A&M University, 3143 TAMU, College Station, TX, 77843, USA., Bernard JA; Department of Psychological and Brain Sciences, Texas A&M University, 4235 TAMU, College Station, TX, 77840, USA.; Texas A&M University Institute for Neuroscience, 3474 TAMU, College Station, TX, 77843, USA. |
| المصدر: | Brain structure & function [Brain Struct Funct] 2022 Sep; Vol. 227 (7), pp. 2439-2455. Date of Electronic Publication: 2022 Jul 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101282001 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1863-2661 (Electronic) Linking ISSN: 18632653 NLM ISO Abbreviation: Brain Struct Funct Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Springer-Verlag, c2007- |
| مواضيع طبية MeSH: | Magnetic Resonance Imaging* , Quality of Life*, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aging ; Cerebellum ; Cognition ; Female ; Humans ; Male ; Middle Aged ; Young Adult |
| مستخلص: | The cerebellum has established associations with motor function and a well-recognized role in cognition. In advanced age, cognitive and motor impairments contribute to reduced quality of life and are more common. Regional cerebellar volume is associated with performance across these domains and sex hormones may influence this volume. Examining sex differences in regional cerebellar volume in conjunction with age, and in the context of reproductive stage stands to improve our understanding of cerebellar aging and pathology. Data from 508 healthy adults (ages 18-88; 47% female) from the Cambridge Centre for Ageing and Neuroscience database were used here. CERES was used to assess lobular volume in T1-weighted images. We examined sex differences in adjusted regional cerebellar volume while controlling for age. A subgroup of participants (n = 370, 50% female) was used to assess group differences in female reproductive stages as compared to age-matched males. Sex differences in adjusted volume were seen across most anterior and posterior cerebellar lobules. Most of these lobules had significant linear relationships with age in males and females. While there were no interactions between sex and reproductive stage groups, exploratory analyses in females alone revealed multiple regional differences by reproductive stage. We found sex differences in volume across much of the cerebellum, linear associations with age, and did not find an interaction for sex and reproductive stage on regional cerebellar volume. Longitudinal investigation into hormonal influences on cerebellar structure and function is warranted as hormonal changes with menopause may impact cerebellar volume over time. (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| معلومات مُعتمدة: | R01 AG064010 United States AG NIA NIH HHS; R01AG065010 United States AG NIA NIH HHS |
| فهرسة مساهمة: | Keywords: Aging; Cerebellum; Menopause; Sex differences; Structural brain imaging |
| تواريخ الأحداث: | Date Created: 20220725 Date Completed: 20220830 Latest Revision: 20230902 |
| رمز التحديث: | 20230902 |
| مُعرف محوري في PubMed: | PMC10167909 |
| DOI: | 10.1007/s00429-022-02535-5 |
| PMID: | 35876952 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1863-2661 |
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| DOI: | 10.1007/s00429-022-02535-5 |