دورية أكاديمية
Pneumocystis jirovecii Pneumonia with a Normal Early Chest Radiography and Complicated with Drug-Induced Immune Hemolytic Anemia: A Case Report.
| العنوان: | Pneumocystis jirovecii Pneumonia with a Normal Early Chest Radiography and Complicated with Drug-Induced Immune Hemolytic Anemia: A Case Report. |
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| المؤلفون: | Hamid NC; Department of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia., Malek KA; Department of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia., Nasir NM; Department of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia., Nasir NM; Department of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia. |
| المصدر: | The American journal of case reports [Am J Case Rep] 2022 Jul 26; Vol. 23, pp. e936278. Date of Electronic Publication: 2022 Jul 26. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: International Scientific Information, Inc Country of Publication: United States NLM ID: 101489566 Publication Model: Electronic Cited Medium: Internet ISSN: 1941-5923 (Electronic) Linking ISSN: 19415923 NLM ISO Abbreviation: Am J Case Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2014- > : Smithtown, NY : International Scientific Information, Inc. Original Publication: Albertson, NY : International Scientific Literature, Inc. |
| مواضيع طبية MeSH: | Anemia, Hemolytic*/chemically induced , HIV Infections*/complications , HIV Infections*/drug therapy , Pneumocystis carinii* , Pneumonia, Pneumocystis*/diagnostic imaging , Pneumonia, Pneumocystis*/drug therapy, Adult ; Humans ; Immunocompromised Host ; Male ; Radiography ; Trimethoprim, Sulfamethoxazole Drug Combination/adverse effects |
| مستخلص: | BACKGROUND Pneumocystis jirovecii pneumonia (PJP) is an opportunistic infection that commonly occurs in immunocompromised patients, especially those with HIV. Early diagnosis and prompt treatment are important because PJP is a potentially life-threatening infection. However, the diagnosis of PJP in the early stage can be challenging due to various factors. Furthermore, the early presentation of PJP, which includes normal chest radiograph and examination findings along with the subacute presentation of PJP in patients with HIV, makes an early diagnosis of the disease even more challenging for doctors. CASE REPORT In this case report, we present the case of a 39-year-old man who had normal chest X-ray findings during the initial stage of his presentation. Coupled with non-disclosure of HIV status, these led to a delay in PJP diagnosis. The diagnosis of PJP with underlying HIV was later supported by the patient's clinical features, initial blood investigations, and presence of high-risk sexual activity. The diagnosis was confirmed when the PJP polymerase chain reaction test from the respiratory sample was positive. He was successfully treated with oral trimethoprim-sulfamethoxazole. However, he subsequently developed rare adverse effects of drug-induced immune hemolytic anemia, which was diagnosed based on the presence of hemolytic anemia and recent exposure to a new drug. Trimethoprim-sulfamethoxazole was promptly discontinued, which resulted in symptom improvement. CONCLUSIONS This case report aims to create awareness among primary care doctors to be vigilant of the PJP diagnosis and its nonspecific presentations as well as to the rare adverse effects of medications to treat PJP. |
| References: | AJR Am J Roentgenol. 1999 May;172(5):1301-9. (PMID: 10227507) Crit Care. 2018 Nov 19;22(1):307. (PMID: 30454031) Am J Case Rep. 2018 Aug 08;19:927-931. (PMID: 30087316) Respiration. 2018;96(1):52-65. (PMID: 29635251) Front Med (Lausanne). 2021 Aug 12;8:697192. (PMID: 34485334) Br J Haematol. 2017 Apr;177(2):208-220. (PMID: 28369704) J Clin Diagn Res. 2015 Mar;9(3):JE01-4. (PMID: 25954636) Med Mal Infect. 2014 May;44(5):185-98. (PMID: 24630595) AIDS Behav. 2021 Sep;25(9):2898-2906. (PMID: 33788120) BMJ Case Rep. 2017 Oct 24;2017:. (PMID: 29066657) JAMA Netw Open. 2018 Nov 2;1(7):e185293. (PMID: 30646397) J Infect Chemother. 2007 Feb;13(1):1-7. (PMID: 17334722) Ther Adv Respir Dis. 2011 Feb;5(1):41-59. (PMID: 20736243) Acta Haematol. 2018;140(1):18-19. (PMID: 30007988) |
| المشرفين على المادة: | 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination) |
| تواريخ الأحداث: | Date Created: 20220726 Date Completed: 20220727 Latest Revision: 20220816 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9339255 |
| DOI: | 10.12659/AJCR.936278 |
| PMID: | 35879878 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1941-5923 |
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| DOI: | 10.12659/AJCR.936278 |