دورية أكاديمية
أعرض في EDS

Vascular Calcification Is Associated with Fetuin-A and Cortical Bone Porosity in Stone Formers.

التفاصيل البيبلوغرافية
العنوان: Vascular Calcification Is Associated with Fetuin-A and Cortical Bone Porosity in Stone Formers.
المؤلفون: Rodrigues FG; Nutrition Post Graduation Program, Universidade Federal de São Paulo (UNIFESP), São Paulo 04023-062, Brazil.; Department of Nephrology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands., Neves RFCA; Hospital do Rim, Fundação Oswaldo Ramos, São Paulo 04038-002, Brazil., Ormanji MS; Nephrology Division, Universidade Federal de São Paulo (UNIFESP), São Paulo 04023-062, Brazil., Esper PLG; Nephrology Division, Universidade Federal de São Paulo (UNIFESP), São Paulo 04023-062, Brazil., Gaspar M; Hospital do Rim, Fundação Oswaldo Ramos, São Paulo 04038-002, Brazil., Pereira RMR; Rheumatology Division, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo 04023-062, Brazil., Requião-Moura LR; Hospital do Rim, Fundação Oswaldo Ramos, São Paulo 04038-002, Brazil.; Nephrology Division, Universidade Federal de São Paulo (UNIFESP), São Paulo 04023-062, Brazil., de Borst MH; Department of Nephrology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands., Heilberg IP; Nutrition Post Graduation Program, Universidade Federal de São Paulo (UNIFESP), São Paulo 04023-062, Brazil.; Nephrology Division, Universidade Federal de São Paulo (UNIFESP), São Paulo 04023-062, Brazil.
المصدر: Journal of personalized medicine [J Pers Med] 2022 Jul 10; Vol. 12 (7). Date of Electronic Publication: 2022 Jul 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101602269 Publication Model: Electronic Cited Medium: Print ISSN: 2075-4426 (Print) Linking ISSN: 20754426 NLM ISO Abbreviation: J Pers Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, 2011-
مستخلص: Background: Nephrolithiasis has been associated with bone loss and vascular calcification (VC), reflecting abnormal extraosseous calcium deposition. Fetuin-A (Fet-A) acts as a potent inhibitor of ectopic mineralization. The aim of the present study was to evaluate the prevalence of VC in stone formers (SF) and non-stone formers (NSF) and to investigate potential determinants of VC among SF, including circulating levels of Fet-A and bone microarchitecture parameters. Methods: Abdominal aortic calcification (AAC) was assessed using available computed tomography in SF and in age-, sex-, and BMI-matched NSF (potential living kidney donors). Serum Fet-A was measured in stored blood samples from SF. Bone microarchitecture parameters were obtained as a post hoc analysis of a cross-sectional cohort from young SF evaluated by high-resolution peripheral quantitative computed tomography (HR-pQCT). Results: A total of 62 SF (38.0 [28.0−45.3] years old) and 80 NSF (40.0 [37.0−45.8] years old) were included. There was no significant difference in AAC scores between SF and NSF. However, when dividing SF according to mean AAC score, below <5.8% (n = 33) or above ≥5.8% (n = 29), SF with higher AAC presented significantly higher BMI and tibial cortical porosity (Ct.Po) and significantly lower serum HDL, klotho, Fet-A, and eGFR. Urinary calcium did not differ between groups, but fractional excretion of phosphate was higher in the former. Upon multivariate regression, BMI, serum Fet-A, and tibial Ct.Po remained independently associated with AAC. Conclusions: This study suggests an association between reduced circulating Fet-A levels and increased bone Ct.Po with VC in SF.
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فهرسة مساهمة: Keywords: HR-pQCT; bone; fetuin-A; kidney stones; nephrolithiasis; vascular calcification
تواريخ الأحداث: Date Created: 20220727 Latest Revision: 20230308
رمز التحديث: 20230309
مُعرف محوري في PubMed: PMC9319706
DOI: 10.3390/jpm12071120
PMID: 35887617
قاعدة البيانات: MEDLINE
الوصف
تدمد:2075-4426
DOI:10.3390/jpm12071120