Comparison of PMT-based TF64 and SiPM-based Vereos PET/CT systems for 90 Y imaging and dosimetry optimization: A quantitative study.

التفاصيل البيبلوغرافية
العنوان:	Comparison of PMT-based TF64 and SiPM-based Vereos PET/CT systems for ⁹⁰ Y imaging and dosimetry optimization: A quantitative study.
المؤلفون:	Trotta N; Department, of Nuclear Medicine, Hôpital Erasme, Université libre de Bruxelles (ULB), Brussels, Belgium., Collette B; Department, of Nuclear Medicine, Hôpital Erasme, Université libre de Bruxelles (ULB), Brussels, Belgium., Mathey C; Department, of Nuclear Medicine, Hôpital Erasme, Université libre de Bruxelles (ULB), Brussels, Belgium., Vierasu I; Department, of Nuclear Medicine, Hôpital Erasme, Université libre de Bruxelles (ULB), Brussels, Belgium., Bucalau AM; Department of Gastroenterology, Hôpital Erasme, Université libre de Bruxelles (ULB), Brussels, Belgium., Verset G; Department of Gastroenterology, Hôpital Erasme, Université libre de Bruxelles (ULB), Brussels, Belgium., Moreno-Reyes R; Department, of Nuclear Medicine, Hôpital Erasme, Université libre de Bruxelles (ULB), Brussels, Belgium., Goldman S; Department, of Nuclear Medicine, Hôpital Erasme, Université libre de Bruxelles (ULB), Brussels, Belgium.
المصدر:	Medical physics [Med Phys] 2022 Dec; Vol. 49 (12), pp. 7567-7582. Date of Electronic Publication: 2022 Aug 08.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: John Wiley and Sons, Inc Country of Publication: United States NLM ID: 0425746 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2473-4209 (Electronic) Linking ISSN: 00942405 NLM ISO Abbreviation: Med Phys Subsets: MEDLINE
أسماء مطبوعة:	Publication: 2017- : Hoboken, NJ : John Wiley and Sons, Inc. Original Publication: Lancaster, Pa., Published for the American Assn. of Physicists in Medicine by the American Institute of Physics.
مواضيع طبية MeSH:	Positron Emission Tomography Computed Tomography* , Liver Neoplasms*/radiotherapy, Humans ; Positron-Emission Tomography/methods ; Radiometry/methods ; Phantoms, Imaging ; Yttrium Radioisotopes/therapeutic use
مستخلص:	Background: Selective internal radiotherapy based on transarterial radioembolization (TARE) with yttrium-90 ( ⁹⁰ Y) microspheres is an established treatment for primary or metastatic liver disease. Purpose: The objective of this work is to optimize the dosimetry of patients treated with ⁹⁰ Y TARE, using positron emission tomography (PET) images. Methods: The NEMA 2012 PET phantom was filled with nearly 3.9 GBq of ⁹⁰ Y activity and acquired at days 0, 3, 5, 7, and 9 on a classic time-of-flight PET/computed tomography (CT) scanner (Philips TF64) and on a silicon photomultiplier (SiPM)-based PET/CT scanner (Philips Vereos). Acquisitions were carried on following the guidelines proposed in a previously published multicentric trial and images were reconstructed by varying and combining the available parameters. Comparisons were performed to identify the best set(s) of parameters leading to the most accurate ⁹⁰ Y-PET image(s), in terms of activity distribution. Then, for both scanners, the best images were analyzed with Simplicit ⁹⁰ Y, a personalized dosimetry software using multicompartmental Medical Internal Radiation Dose model. The comparison between measured and true doses allowed to identify the image granting the most consistent dose estimations and, therefore, to designate the set of parameters to be applied on patients' data for the reconstruction of optimized clinical images. Posttreatment dosimetry of four patients was then realized with Simplicit ⁹⁰ Y using optimized imaging datasets. Results: Based on activity distribution comparisons and dose estimations over phantom and patients data, the SiPM-based PET/CT system appeared more suitable than the photomultiplier tube-based TF64 for ⁹⁰ Y-PET imaging. With the SiPM-based PET/CT system, reconstructed images with a 2-mm voxel size combined with the application of the point spread function correction led to the most accurate results for quantitative ⁹⁰ Y measures. Conclusions: For the SiPM-based PET/CT scanner, an optimized set of reconstruction parameters has been identified and applied on patients' data in order to generate the most accurate image to be used for an improved personalized ⁹⁰ Y-PET dosimetry, ensuring a reliable evaluation of the delivered doses. (© 2022 American Association of Physicists in Medicine.)
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فهرسة مساهمة:	Keywords: 90Y-selective internal radiotherapy; image reconstruction optimization; personalized dosimetry; positron emission tomography
المشرفين على المادة:	0 (Yttrium Radioisotopes)
تواريخ الأحداث:	Date Created: 20220727 Date Completed: 20221227 Latest Revision: 20221230
رمز التحديث:	20231215
DOI:	10.1002/mp.15880
PMID:	35894818
قاعدة البيانات:	MEDLINE

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تدمد:	2473-4209
DOI:	10.1002/mp.15880