دورية أكاديمية
Pneumonia, Meningitis, and Septicemia in Adults and Older Children in Rural Gambia: 8 Years of Population-Based Surveillance.
| العنوان: | Pneumonia, Meningitis, and Septicemia in Adults and Older Children in Rural Gambia: 8 Years of Population-Based Surveillance. |
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| المؤلفون: | Green EW; Medical Research Council Unit The Gambia, London School of Hygiene and Tropical Medicine, Fajara, The Gambia.; Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Ndiaye M; Medical Research Council Unit The Gambia, London School of Hygiene and Tropical Medicine, Fajara, The Gambia., Hossain IM; Medical Research Council Unit The Gambia, London School of Hygiene and Tropical Medicine, Fajara, The Gambia., Olatunji YA; Medical Research Council Unit The Gambia, London School of Hygiene and Tropical Medicine, Fajara, The Gambia., Sahito SM; Medical Research Council Unit The Gambia, London School of Hygiene and Tropical Medicine, Fajara, The Gambia., Salaudeen R; Medical Research Council Unit The Gambia, London School of Hygiene and Tropical Medicine, Fajara, The Gambia., Badji H; Medical Research Council Unit The Gambia, London School of Hygiene and Tropical Medicine, Fajara, The Gambia., Manjang A; Medical Research Council Unit The Gambia, London School of Hygiene and Tropical Medicine, Fajara, The Gambia., Ceesay L; Ministry of Health and Social Welfare, Banjul, The Gambia., Hill PC; Centre for International Health, University of Otago, Dunedin, New Zealand., Greenwood B; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom., Mackenzie GA; Medical Research Council Unit The Gambia, London School of Hygiene and Tropical Medicine, Fajara, The Gambia.; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.; Murdoch Children's Research Institute, Melbourne, Australia. |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2023 Feb 18; Vol. 76 (4), pp. 694-703. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: Chicago, IL : The University of Chicago Press, c1992- |
| مواضيع طبية MeSH: | Pneumonia* , Meningitis* , Sepsis* , Meningitis, Bacterial*/epidemiology, Child ; Humans ; Adult ; Infant ; Adolescent ; Gambia/epidemiology ; Aftercare ; Patient Discharge |
| مستخلص: | Background: Representative data describing serious infections in children aged ≥5 years and adults in Africa are limited. Methods: We conducted population-based surveillance for pneumonia, meningitis, and septicemia in a demographic surveillance area in The Gambia between 12 May 2008 and 31 December 2015. We used standardized criteria to identify, diagnose, and investigate patients aged ≥5 years using conventional microbiology and radiology. Results: We enrolled 1638 of 1657 eligible patients and investigated 1618. Suspected pneumonia, septicemia, or meningitis was diagnosed in 1392, 135, and 111 patients, respectively. Bacterial pathogens from sterile sites were isolated from 105 (7.5%) patients with suspected pneumonia, 11 (8.1%) with suspected septicemia, and 28 (25.2%) with suspected meningitis. Streptococcus pneumoniae (n = 84), Neisseria meningitidis (n = 16), and Staphylococcus aureus (n = 15) were the most common pathogens. Twenty-eight (1.7%) patients died in hospital and 40 (4.1%) died during the 4 months after discharge. Thirty postdischarge deaths occurred in patients aged ≥10 years with suspected pneumonia. The minimum annual incidence was 133 cases per 100 000 person-years for suspected pneumonia, 13 for meningitis, 11 for septicemia, 14 for culture-positive disease, and 46 for radiological pneumonia. At least 2.7% of all deaths in the surveillance area were due to suspected pneumonia, meningitis, or septicemia. Conclusions: Pneumonia, meningitis, and septicemia in children aged ≥5 years and adults in The Gambia are responsible for significant morbidity and mortality. Many deaths occur after hospital discharge and most cases are culture negative. Improvements in prevention, diagnosis, inpatient, and follow-up management are urgently needed. Competing Interests: Potential conflicts of interest. G. A. M. reports research funding to institution from the Wellcome Trust, the MRC–United Kingdom Research and Innovation, and the UK National Institute for Health Research Mucosal Pathogens Research Unit. G. A. M. is a member of the International Scientific Committee (unpaid) at the World Society of Paediatric Infectious Diseases. G. A. M. and B. G. have received research funding grants from the Bill & Melinda Gates Foundation. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.) |
| معلومات مُعتمدة: | MC_UU_00031/8 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: Africa; epidemiology; meningitis; pneumonia; sepsis |
| تواريخ الأحداث: | Date Created: 20220729 Date Completed: 20230224 Latest Revision: 20230329 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9938739 |
| DOI: | 10.1093/cid/ciac603 |
| PMID: | 35903006 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6591 |
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| DOI: | 10.1093/cid/ciac603 |