دورية أكاديمية
Lasting Effects of Helicobacter pylori Infection on the Microbial Communities of Patients with and without Small Intestinal Bacterial Overgrowth.
| العنوان: | Lasting Effects of Helicobacter pylori Infection on the Microbial Communities of Patients with and without Small Intestinal Bacterial Overgrowth. |
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| المؤلفون: | Perets TT; Gastroenterology Laboratory and the Division of Gastroenterology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel; Holon Institute of Technology, Department of Digital Medical Technologies, Holon, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, Ben Simon S; Microbiome Research Lab, Azrieli Faculty of Medicine, Bar-Ilan University, Zefat, Israel, Ashorov O; Gastroenterology Laboratory and the Division of Gastroenterology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel, Hamouda D; Gastroenterology Laboratory and the Division of Gastroenterology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel, Dickman R; Gastroenterology Laboratory and the Division of Gastroenterology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, Turjeman S; Microbiome Research Lab, Azrieli Faculty of Medicine, Bar-Ilan University, Zefat, Israel |
| المصدر: | The new microbiologica [New Microbiol] 2022 Jul; Vol. 45 (3), pp. 193-198. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Edizioni Internazionali srl Country of Publication: Italy NLM ID: 9516291 Publication Model: Print Cited Medium: Print ISSN: 1121-7138 (Print) Linking ISSN: 11217138 NLM ISO Abbreviation: New Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2004- : Pavia, Italy : Edizioni Internazionali srl Original Publication: Pavia, Italy : L. Ponzio e figlio, 1993- |
| مواضيع طبية MeSH: | Helicobacter Infections*/complications , Helicobacter pylori*/genetics , Irritable Bowel Syndrome*/etiology , Irritable Bowel Syndrome*/microbiology , Microbiota*, Animals ; Cattle ; Dysbiosis/complications ; Dysbiosis/microbiology ; Humans ; Intestine, Small/microbiology ; RNA, Ribosomal, 16S/genetics |
| مستخلص: | Gastrointestinal (GI) microbial populations are important in maintaining normal functioning of the GI by preventing disorders. Dysbiotic microbiota may increase the likelihood of small intestinal bacterial overgrowth (SIBO), a syndrome associated with significant morbidity. We aimed to inves- tigate the microbiota populations of patients with SIBO. Patients with symptoms of SIBO were consecutively enrolled; they underwent a SIBO hydrogen breath test and stool was collected for microbiome analysis by sequencing of the 16S rRNA. Of the 55 patients recruited, 42 (76.4%) were positive for SIBO. When visualizing the bacterial β-di- versity, a sub-cluster of patients was identified. Further examination of these patients' records re- vealed previous treatment for Helicobacter pylori (HP). Microbiome analysis of these patients demonstrated a significant decrease in β-diversity (p-value<0.001) compared to patients without previous HP therapy. Furthermore, β-diversity was significantly different in this subgroup, and sev- eral bacterial taxa were differentially expressed, including one from the genus Methanobrevibacter, which was reduced in patients that previously underwent HP treatment. Our findings suggest that while symptoms associated with SIBO may cause dysbiosis, there was no differentiation in fecal microbiome composition based on SIBO diagnosis. Furthermore, our results support previous observations regarding antibiotic-altered microbiota with effects extending two and three years post-treatment. |
| فهرسة مساهمة: | Keywords: Dysbiotic microbiota; microbiome analysis; antibiotic-altered microbiota |
| المشرفين على المادة: | 0 (RNA, Ribosomal, 16S) |
| تواريخ الأحداث: | Date Created: 20220803 Date Completed: 20220805 Latest Revision: 20220808 |
| رمز التحديث: | 20221213 |
| PMID: | 35920874 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1121-7138 |
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