New bioactive flavonoid glycosides with antioxidant activity from the stem bark of Olax subscorpioidea Oliv.

التفاصيل البيبلوغرافية
العنوان:	New bioactive flavonoid glycosides with antioxidant activity from the stem bark of Olax subscorpioidea Oliv.
المؤلفون:	Tsakem B; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Tchuenguem RT; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Siwe-Noundou X; Department of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, South Africa., Kemvoufo BP; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Dzoyem JP; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Teponno RB; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Krause RWM; Department of Chemistry, Rhodes University, Grahamstown, South Africa., Tapondjou LA; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
المصدر:	Natural product research [Nat Prod Res] 2023 May; Vol. 37 (10), pp. 1641-1650. Date of Electronic Publication: 2022 Aug 03.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003-
مواضيع طبية MeSH:	Flavonoids/chemistry , Antioxidants/chemistry, Plant Bark/chemistry ; Plant Extracts/chemistry ; Glycosides/chemistry
مستخلص:	A previously unreported gallocatechin glycoside, (2 R ,3 S ) 4'- O -methyl-gallocatechin-3- O -α-ʟ-rhamnopyranoside ( 1 ) and an unseparable mixture of two previously undescribed dihydromyricetin glycosides, (2 R ,3 R ) 4'- O -methyl-dihydromyricetin-3- O -α-ʟ-rhamnopyranoside ( 2a ) and (2 R ,3 S ) 4'- O -methyl-dihydromyricetin-3- O -α-ʟ-rhamnopyranoside ( 2 b ) along with three known compounds were isolated from the n -butanol soluble fraction of the stem bark of Olax subscorpioidea Oliv. Their structures were elucidated by detailed spectroscopic analyses, including ¹ H NMR, ¹³ C NMR, ¹ H- ¹ H COSY, HSQC, HMBC, NOESY, HR-ESI-MS and chemical methods. The crude ethanol extract, the fractions, and some of the isolated compounds were screened for their antioxidant and antibacterial activities. They showed significant antioxidant activities with EC 50 ranging from 6.29 to 18.19 µg/mL in 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and EC 50 ranging from 85.77 to 86.39 mmol FeSO 4 /g in ferric reducing antioxidant power (FRAP) methods compared with 2.29 µg/mL and 3.52 mmol FeSO 4 /g for the positive control (ʟ-ascorbic acid). Nevertheless, no inhibition was observed against the tested bacterial strains at a MIC less than 256 μg/mL.
فهرسة مساهمة:	Keywords: Olax subscorpioidea; antioxidant activity; dihydromyricetin; flavonoid glycosides; gallocatechin; structural elucidation
المشرفين على المادة:	0 (Flavonoids) 0 (Antioxidants) 0 (Plant Extracts) 0 (Glycosides)
تواريخ الأحداث:	Date Created: 20220803 Date Completed: 20230420 Latest Revision: 20230420
رمز التحديث:	20240829
DOI:	10.1080/14786419.2022.2106566
PMID:	35921518
قاعدة البيانات:	MEDLINE

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تدمد:	1478-6427
DOI:	10.1080/14786419.2022.2106566