دورية أكاديمية
Insight into the structural basis of the dual inhibitory mode of Lima bean (Phaseolus lunatus) serine protease inhibitor.
| العنوان: | Insight into the structural basis of the dual inhibitory mode of Lima bean (Phaseolus lunatus) serine protease inhibitor. |
|---|---|
| المؤلفون: | Ahmad MS; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan., Akbar Z; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan., Choudhary MI; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia. |
| المصدر: | Proteins [Proteins] 2023 Jan; Vol. 91 (1), pp. 22-31. Date of Electronic Publication: 2022 Aug 23. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8700181 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0134 (Electronic) Linking ISSN: 08873585 NLM ISO Abbreviation: Proteins Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Wiley-Liss Original Publication: New York : Alan R. Liss, c1986- |
| مواضيع طبية MeSH: | Trypsin Inhibitor, Bowman-Birk Soybean*/chemistry , Trypsin Inhibitor, Bowman-Birk Soybean*/metabolism , Phaseolus*, Cattle ; Animals ; Trypsin/metabolism ; Serine Proteinase Inhibitors/pharmacology ; Amino Acid Sequence ; Trypsin Inhibitors/chemistry ; Trypsin Inhibitors/metabolism ; Chymotrypsin |
| مستخلص: | Bovine pancreatic trypsin was crystallized, in-complex with Lima bean trypsin inhibitor (LBTI) (Phaseolus lunatus L.), in the form of a ternary complex. LBTI is a Bowman-Birk-type bifunctional serine protease inhibitor, which has two independent inhibitory loops. Both of the loops can inhibit trypsin, however, only the hydrophobic loop is specific for inhibiting chymotrypsin. The structure of trypsin incomplex with the LBTI has been solved and refined at 2.25 Å resolution, in the space group P4 (© 2022 Wiley Periodicals LLC.) |
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| فهرسة مساهمة: | Keywords: Bowman-Birk-type inhibitors; Lima bean; Lima bean trypsin inhibitor; pancreatitis; serine protease; trypsin |
| المشرفين على المادة: | 0 (Trypsin Inhibitor, Bowman-Birk Soybean) EC 3.4.21.4 (Trypsin) 0 (Serine Proteinase Inhibitors) 0 (Trypsin Inhibitors) EC 3.4.21.1 (Chymotrypsin) |
| تواريخ الأحداث: | Date Created: 20220804 Date Completed: 20221215 Latest Revision: 20230220 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1002/prot.26407 |
| PMID: | 35927030 |
| قاعدة البيانات: | MEDLINE |
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