دورية أكاديمية
أعرض في EDS

Gene profiling in dorso-ventral patterning of mouse tongue development.

التفاصيل البيبلوغرافية
العنوان: Gene profiling in dorso-ventral patterning of mouse tongue development.
المؤلفون: Kim TY; Department of Biochemistry, School of Dentistry, IHBR, Kyungpook National University, 2177 Dalgubeol-daero, Jung-gu, 41940, Daegu, Korea., Jung HG; Department of Biochemistry, School of Dentistry, IHBR, Kyungpook National University, 2177 Dalgubeol-daero, Jung-gu, 41940, Daegu, Korea., Pokharel E; Department of Biochemistry, School of Dentistry, IHBR, Kyungpook National University, 2177 Dalgubeol-daero, Jung-gu, 41940, Daegu, Korea., Kim JY; Department of Dental Hygiene, Gachon University, Incheon, Korea., Ha JH; Department of Conservative Dentistry, School of Dentistry, Kyungpook National University, Daegu, Korea., An SY; Department of Oral and Maxillofacial Radiology, School of Dentistry, Kyungpook National University, Daegu, Korea., An CH; Department of Oral and Maxillofacial Radiology, School of Dentistry, Kyungpook National University, Daegu, Korea., Sohn WJ; Pre-Major of Cosmetics and Pharmaceutics, Daegu Haany University, Gyeongsan, Korea., Jung JK; Department of Oral Medicine, School of Dentistry, Kyungpook National University, Daegu, Korea., Aryal YP; Department of Biochemistry, School of Dentistry, IHBR, Kyungpook National University, 2177 Dalgubeol-daero, Jung-gu, 41940, Daegu, Korea. yparyal86@gmail.com., Kim JY; Department of Biochemistry, School of Dentistry, IHBR, Kyungpook National University, 2177 Dalgubeol-daero, Jung-gu, 41940, Daegu, Korea. jykim91@knu.ac.kr.
المصدر: Genes & genomics [Genes Genomics] 2022 Oct; Vol. 44 (10), pp. 1181-1189. Date of Electronic Publication: 2022 Aug 11.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: The Korean Society of Genetics Country of Publication: Korea (South) NLM ID: 101481027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2092-9293 (Electronic) Linking ISSN: 19769571 NLM ISO Abbreviation: Genes Genomics Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Seoul : The Korean Society of Genetics, 2008-
مواضيع طبية MeSH: Angiopoietin-2* , Calcium*, Animals ; Mice ; Organogenesis ; RNA ; Tongue
مستخلص: Background: The tongue is a muscular fleshy organ in the oral cavity that is anatomically divided into the dorsal, ventral, anterior, and posterior part. The intricate tissue organisation and diverse origins of the tongue make it a complex organ of the oral cavity.
Objectives: To reveal the signalling molecules involved in the formation of the dorsal and ventral parts of the tongue through microarray analysis.
Methods: Dorsal and ventral tongue tissues were isolated from embryonic day 14 mice by micro-dissection. RNA was extracted from the dorsal and ventral tongue tissues separately for microarray analysis. Microarray data were confirmed by quantitative reverse transcription polymerase chain reaction and whole-mount in situ hybridisation.
Results: Microarray analysis revealed expression of 33,793 genes. Of these, 931 genes were found to be equally expressed in both the dorsal and ventral parts of the tongue. On limiting the fold-change cut-off to over 1.5-fold, 725 genes were expressed over 1.5-fold in the ventral part and 1,672 in the dorsal part of the tongue. The qPCR and whole-mount in situ hybridisation revealed the expressions of angiopoietin 2 (Angpt2), fibroblast growth factor 18 (Fgf18), mesenchyme homeobox gene1 (Meox1), and SPARC-related modular calcium binding 2 (Smoc2) in the ventral part of the tongue.
Conclusions: Numerous signalling molecules can be selected from our microarray results to examine their roles in tongue development and disease model systems. In the near future, the selection of candidate genes and their functional evaluations will be performed through loss- and gain-of-function mutation studies.
(© 2022. The Author(s) under exclusive licence to The Genetics Society of Korea.)
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فهرسة مساهمة: Keywords: Angpt2; Fgf18; Meox1; Microarray analysis; Smoc2; Tongue
المشرفين على المادة: 0 (Angiopoietin-2)
63231-63-0 (RNA)
SY7Q814VUP (Calcium)
تواريخ الأحداث: Date Created: 20220811 Date Completed: 20220919 Latest Revision: 20221024
رمز التحديث: 20221213
DOI: 10.1007/s13258-022-01282-5
PMID: 35951154
قاعدة البيانات: MEDLINE
الوصف
تدمد:2092-9293
DOI:10.1007/s13258-022-01282-5