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Association and Interaction Effect of BHMT Gene Polymorphisms and Maternal Dietary Habits with Ventricular Septal Defect in Offspring.

التفاصيل البيبلوغرافية
العنوان: Association and Interaction Effect of BHMT Gene Polymorphisms and Maternal Dietary Habits with Ventricular Septal Defect in Offspring.
المؤلفون: Luo M; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China., Wang T; National Health Committee Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410028, China., Huang P; Department of Cardiothoracic Surgery, Hunan Children's Hospital, Changsha 410007, China., Zhang S; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China., Song X; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China., Sun M; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China., Liu Y; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China., Wei J; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China., Shu J; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China., Zhong T; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China., Chen Q; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China., Zhu P; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China., Qin J; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China.; National Health Committee Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410028, China.; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.; Hunan Provincial Key Laboratory of Clinical Epidemiology, Changsha 410078, China.; Guangdong Provincial Key Laboratory of Pathogenesis, Targeted Prevention and Treatment of Heart Disease, Guangzhou 510640, China.
المصدر: Nutrients [Nutrients] 2022 Jul 28; Vol. 14 (15). Date of Electronic Publication: 2022 Jul 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Betaine-Homocysteine S-Methyltransferase*/genetics , Heart Septal Defects, Ventricular*, Animals ; Feeding Behavior ; Female ; Humans ; Mothers ; Polymorphism, Genetic
مستخلص: This study attempted to learn the association between maternal betaine-homocysteine methyltransferase ( BHMT ) gene polymorphisms, maternal dietary habits, and their interactions with the risk of ventricular septal defects (VSD) in offspring. A total of 426 mothers of VSD children and 740 control mothers were included in the study. Logistic regression was used to evaluate the level of associations and interaction effects. Our study suggested that mothers reporting excessive intake of smoked foods (aOR = 2.44, 95%CI: 1.89-3.13), barbecued foods (aOR = 1.86, 95%CI: 1.39-2.48), fried foods (aOR = 1.93, 95%CI: 1.51-2.46), and pickled vegetables (aOR = 2.50, 95%CI: 1.92-3.25) were at a significantly higher risk of VSD in offspring, instead, mothers reporting regular intake of fresh fruits (aOR = 0.47, 95%CI: 0.36-0.62), fish and shrimp (aOR = 0.35, 95%CI: 0.28-0.44), fresh eggs, (aOR = 0.56, 95%CI: 0.45-0.71), beans (aOR = 0.68, 95%CI: 0.56-0.83), and milk products (aOR = 0.67, 95%CI: 0.56-0.80) were at a lower risk of VSD in offspring. In addition, maternal BHMT gene polymorphisms at rs1316753 (CG vs. CC: aOR = 2.01, 95%CI: 1.43-2.83) and rs1915706 (CT vs. TT: (aOR = 1.81, 95%CI: 1.33-2.46) were significantly associated with increased risk of VSD in offspring. Furthermore, a significant interaction between BHMT polymorphisms and maternal bean intake was identified in the study. In conclusion, Maternal BHMT polymorphisms at rs1316753 and rs1915706, dietary habits as well as their interaction were observed to be significantly associated with the risk of VSD in offspring.
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معلومات مُعتمدة: 2018YFE0114500 National Key Research and Development Project; 82073653 and 81803313 National Natural Science Foundation Program of China; 2020M682644 China Postdoctoral Science Foundation; 2020TJ-N07 Hunan Provincial Science and Technology Talent Support Project; 2018SK2063 and 2018SK2064 Hunan Provincial Key Research and Development Program; 2018JJ2551 Natural Science Foundation of Hunan Province; KF2020006 Open Project from NHC Key Laboratory of Birth Defect for Research and Prevention; 2020A1414010152 Science and Technology Planning Project of Guangdong Province; 2022JJ10087 Hunan Outstanding Youth Fund Project; 2022JJ40207 Natural Science Foundation of Hunan Province of China; kq2202470 Changsha Municipal Natural Science Foundation; 1053320215987 Postgraduate Scientific Research Innovation Project of Central South University
فهرسة مساهمة: Keywords: BHMT gene plolymorphisms; dietary habits; interaction effects; ventricular septal defects
المشرفين على المادة: EC 2.1.1.5 (BHMT protein, human)
EC 2.1.1.5 (Betaine-Homocysteine S-Methyltransferase)
تواريخ الأحداث: Date Created: 20220812 Date Completed: 20220815 Latest Revision: 20220815
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9370527
DOI: 10.3390/nu14153094
PMID: 35956270
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu14153094