دورية أكاديمية
TGF-β regulates the stem-like state of PD-1+ TCF-1+ virus-specific CD8 T cells during chronic infection.
| العنوان: | TGF-β regulates the stem-like state of PD-1+ TCF-1+ virus-specific CD8 T cells during chronic infection. |
|---|---|
| المؤلفون: | Hu Y; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA., Hudson WH; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA., Kissick HT; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.; Winship Cancer Institute of Emory University, Atlanta, GA.; Department of Urology, Emory University School of Medicine, Atlanta, GA., Medina CB; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA., Baptista AP; Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGhent Center for Inflammation Research, Ghent University, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Ma C; Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX., Liao W; Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX.; Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Germain RN; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Turley SJ; Genentech Inc., South San Francisco, CA., Zhang N; Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX., Ahmed R; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA. |
| المصدر: | The Journal of experimental medicine [J Exp Med] 2022 Oct 03; Vol. 219 (10). Date of Electronic Publication: 2022 Aug 18. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Rockefeller University Press |
| مواضيع طبية MeSH: | Lymphocytic Choriomeningitis* , Neoplasms*, Animals ; CD8-Positive T-Lymphocytes ; Lymphocytic choriomeningitis virus/physiology ; Mice ; Persistent Infection ; Programmed Cell Death 1 Receptor ; Transforming Growth Factor beta |
| مستخلص: | Recent studies have defined a novel population of PD-1+ TCF-1+ stem-like CD8 T cells in chronic infections and cancer. These quiescent cells reside in lymphoid tissues, are critical for maintaining the CD8 T cell response under conditions of persistent antigen, and provide the proliferative burst after PD-1 blockade. Here we examined the role of TGF-β in regulating the differentiation of virus-specific CD8 T cells during chronic LCMV infection of mice. We found that TGF-β signaling was not essential for the generation of the stem-like CD8 T cells but was critical for maintaining the stem-like state and quiescence of these cells. TGF-β regulated the unique transcriptional program of the stem-like subset, including upregulation of inhibitory receptors specifically expressed on these cells. TGF-β also promoted the terminal differentiation of exhausted CD8 T cells by suppressing the effector-associated program. Together, the absence of TGF-β signaling resulted in significantly increased accumulation of effector-like CD8 T cells. These findings have implications for immunotherapies in general and especially for T cell therapy against chronic infections and cancer. (© 2022 Hu et al.) |
| References: | J Exp Med. 2022 Oct 3;219(10):. (PMID: 35980385) BMC Bioinformatics. 2016 Aug 23;17(1):315. (PMID: 27553427) Immunity. 2016 Aug 16;45(2):415-27. (PMID: 27533016) Immunity. 2014 Dec 18;41(6):886-97. (PMID: 25526304) Cell Rep. 2018 Mar 27;22(13):3454-3467. (PMID: 29590615) Nature. 2019 Jul;571(7764):211-218. (PMID: 31207603) Nature. 2016 Sep 15;537(7620):417-421. (PMID: 27501248) Cold Spring Harb Perspect Biol. 2017 Jun 1;9(6):. (PMID: 28108486) Nat Immunol. 2020 Mar;21(3):287-297. (PMID: 31932812) Nat Immunol. 2020 Sep;21(9):1010-1021. (PMID: 32661362) Nature. 2018 Feb 22;554(7693):544-548. (PMID: 29443960) J Exp Med. 2018 Oct 1;215(10):2520-2535. (PMID: 30154266) Immunity. 2018 Oct 16;49(4):678-694.e5. (PMID: 30314757) Nature. 2019 Jul;571(7764):270-274. (PMID: 31207604) Nature. 2006 Feb 9;439(7077):682-7. (PMID: 16382236) Annu Rev Med. 2018 Jan 29;69:301-318. (PMID: 29414259) J Exp Med. 2017 Feb;214(2):381-400. (PMID: 28115575) Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12410-12415. (PMID: 31152140) Nature. 2018 Jul;559(7713):264-268. (PMID: 29973721) Nat Med. 2022 Apr;28(4):724-734. (PMID: 35314843) Nat Commun. 2021 May 13;12(1):2782. (PMID: 33986293) Immunity. 2013 Oct 17;39(4):687-96. (PMID: 24076049) N Engl J Med. 2012 Jun 28;366(26):2455-65. (PMID: 22658128) Annu Rev Immunol. 2019 Apr 26;37:457-495. (PMID: 30676822) J Virol. 1994 Dec;68(12):8056-63. (PMID: 7966595) Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14113-14118. (PMID: 31227606) Immunity. 2009 Jul 17;31(1):145-57. (PMID: 19604493) Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18778-83. (PMID: 22065790) Immunity. 2021 Aug 10;54(8):1698-1714.e5. (PMID: 34233154) Immunity. 2018 Apr 17;48(4):745-759.e6. (PMID: 29669252) Immunity. 2019 Dec 17;51(6):1043-1058.e4. (PMID: 31810882) Nature. 2019 Jul;571(7764):265-269. (PMID: 31207605) J Immunother Cancer. 2018 Jan 23;6(1):8. (PMID: 29357948) Cell. 2003 Jun 13;113(6):685-700. (PMID: 12809600) N Engl J Med. 2012 Jun 28;366(26):2443-54. (PMID: 22658127) Immunity. 2007 Aug;27(2):281-95. (PMID: 17723218) Eur J Immunol. 2008 Feb;38(2):528-36. (PMID: 18203138) J Exp Med. 1998 Dec 21;188(12):2205-13. (PMID: 9858507) J Virol. 2012 Jul;86(13):7060-71. (PMID: 22553324) Cancer Biol Med. 2015 Dec;12(4):385-93. (PMID: 26779375) Nat Immunol. 2013 Dec;14(12):1285-93. (PMID: 24162775) Nature. 1990 Aug 16;346(6285):629-33. (PMID: 1696684) Immunity. 2015 Feb 17;42(2):265-278. (PMID: 25680272) Cell. 2012 Mar 30;149(1):146-58. (PMID: 22464327) Immunity. 2019 Dec 17;51(6):1028-1042.e4. (PMID: 31810883) Nature. 2018 Feb 22;554(7693):538-543. (PMID: 29443964) Nat Immunol. 2020 Dec;21(12):1552-1562. (PMID: 33046887) Nature. 2006 Sep 21;443(7109):350-4. (PMID: 16921384) Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11013-7. (PMID: 26283373) Nat Immunol. 2012 May 27;13(7):667-73. (PMID: 22634866) Immunity. 2007 Oct;27(4):670-84. (PMID: 17950003) Nature. 2016 Aug 2;537(7620):412-428. (PMID: 27501245) J Clin Invest. 2016 Oct 3;126(10):3799-3813. (PMID: 27599295) J Virol. 2003 Apr;77(8):4911-27. (PMID: 12663797) J Exp Med. 2009 Oct 26;206(11):2469-81. (PMID: 19808259) J Exp Med. 1998 May 4;187(9):1383-93. (PMID: 9565631) Nature. 2006 Jul 20;442(7100):299-302. (PMID: 16855590) Immunity. 2019 Apr 16;50(4):924-940. (PMID: 30995507) J Immunol. 2017 Mar 15;198(6):2286-2301. (PMID: 28193829) Nature. 2017 Dec 14;552(7684):253-257. (PMID: 29211713) Cancers (Basel). 2020 Mar 20;12(3):. (PMID: 32245016) Viral Immunol. 2012 Jun;25(3):232-8. (PMID: 22620718) Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4292-4299. (PMID: 32034098) Mucosal Immunol. 2014 Jul;7(4):1006-18. (PMID: 24424524) Sci Immunol. 2016 Dec 23;1(6):. (PMID: 28018990) Clin Exp Immunol. 2013 Jan;171(1):1-7. (PMID: 23199317) |
| معلومات مُعتمدة: | P01 AI056299 United States AI NIAID NIH HHS; P51 OD011132 United States OD NIH HHS; R00 AI153736 United States AI NIAID NIH HHS; S10 OD026799 United States OD NIH HHS; R01 AI030048 United States AI NIAID NIH HHS |
| المشرفين على المادة: | 0 (Programmed Cell Death 1 Receptor) 0 (Transforming Growth Factor beta) |
| تواريخ الأحداث: | Date Created: 20220818 Date Completed: 20220822 Latest Revision: 20230701 |
| رمز التحديث: | 20230701 |
| مُعرف محوري في PubMed: | PMC9393409 |
| DOI: | 10.1084/jem.20211574 |
| PMID: | 35980386 |
| قاعدة البيانات: | MEDLINE |
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