دورية أكاديمية
Effectiveness of melatonin adjuvant treatment in cisplatin to prevent depletion of ovarian follicles in mice: systematic review†.
| العنوان: | Effectiveness of melatonin adjuvant treatment in cisplatin to prevent depletion of ovarian follicles in mice: systematic review†. |
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| المؤلفون: | Rodrigues TD; Laboratory of Translacional Biomedicine, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil., Lima KR; Laboratory of Translacional Biomedicine, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil., Uggioni MLR; Laboratory of Translacional Biomedicine, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil., Ferraz SD; Laboratory of Translacional Biomedicine, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil., Cardoso HS; Laboratory of Translacional Biomedicine, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil., Colonetti T; Laboratory of Translacional Biomedicine, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil., da Rosa MI; Laboratory of Translacional Biomedicine, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil. |
| المصدر: | Biology of reproduction [Biol Reprod] 2022 Dec 10; Vol. 107 (6), pp. 1386-1394. |
| نوع المنشور: | Systematic Review; Meta-Analysis; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0207224 Publication Model: Print Cited Medium: Internet ISSN: 1529-7268 (Electronic) Linking ISSN: 00063363 NLM ISO Abbreviation: Biol Reprod Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Champaign, Ill. : Society for the Study of Reproduction |
| مواضيع طبية MeSH: | Melatonin*/pharmacology , Ovarian Follicle*/drug effects , Ovarian Follicle*/metabolism, Animals ; Female ; Mice ; Cisplatin/therapeutic use |
| مستخلص: | Introduction: Cisplatin-based chemotherapy is the standard cancer therapy; however, this treatment causes depletion of ovarian follicles in women of reproductive age. Adjuvant treatment with melatonin can protect the ovaries from oxidative stress, reducing the side effects of chemotherapy. The objective was to evaluate the effects of the use of melatonin on the ovarian follicles of mice treated with cisplatin. Methodology: A systematic review was performed. The search strategy used the terms: "cisplatin", "melatonin," and "ovarian". MEDLINE EMBASE, Cochrane Library, and gray literature (Google Scholar) were used as databases. The search was limited to experimental studies, performed on animals, with no language restrictions. Results: The search identified 30 studies and 5 primary studies, published between 2016 and 2021, and met the inclusion criteria, with a total of 115 mice. For the p-FOX3a/FOXO3a pathway, the meta-analysis showed a standard mean difference (SMD) of -4.79 (95% CI -6.16 to -3.42; P < 0.00001, two studies, 38 mice; I2 = 0%). For the p-PTEN pathway, the meta-analysis showed an SMD of -1.65 (95% CI -2.71 to -0.59; P = 0.002, two studies, 38 mice; I2 = 47%). Conclusion: Melatonin variation in efficacy varies according to the dose used in mice previously exposed to cisplatin. However, melatonin was able to alter the p-PTEN and p-FOX3a/FOXO3a pathways. (© The Author(s) 2022. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: cisplatin; melatonin; ovarian follicles; systematic review |
| المشرفين على المادة: | Q20Q21Q62J (Cisplatin) JL5DK93RCL (Melatonin) |
| تواريخ الأحداث: | Date Created: 20220818 Date Completed: 20221219 Latest Revision: 20221222 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1093/biolre/ioac164 |
| PMID: | 35980799 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1529-7268 |
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| DOI: | 10.1093/biolre/ioac164 |