دورية أكاديمية
Increasing cell size remodels the proteome and promotes senescence.
| العنوان: | Increasing cell size remodels the proteome and promotes senescence. |
|---|---|
| المؤلفون: | Lanz MC; Department of Biology, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, Stanford, CA 94305, USA., Zatulovskiy E; Department of Biology, Stanford University, Stanford, CA 94305, USA. Electronic address: evgeny@stanford.edu., Swaffer MP; Department of Biology, Stanford University, Stanford, CA 94305, USA., Zhang L; Chan Zuckerberg Biohub, Stanford, CA 94305, USA., Ilerten I; Department of Biology, Stanford University, Stanford, CA 94305, USA., Zhang S; Department of Biology, Stanford University, Stanford, CA 94305, USA., You DS; Department of Biology, Stanford University, Stanford, CA 94305, USA., Marinov G; Department of Genetics, Stanford University, Stanford, CA 94305, USA., McAlpine P; Chan Zuckerberg Biohub, Stanford, CA 94305, USA., Elias JE; Chan Zuckerberg Biohub, Stanford, CA 94305, USA., Skotheim JM; Department of Biology, Stanford University, Stanford, CA 94305, USA. Electronic address: skotheim@stanford.edu. |
| المصدر: | Molecular cell [Mol Cell] 2022 Sep 01; Vol. 82 (17), pp. 3255-3269.e8. Date of Electronic Publication: 2022 Aug 19. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge Ma : Cell Press Original Publication: Cambridge, Mass. : Cell Press, c1997- |
| مواضيع طبية MeSH: | Cellular Senescence*/physiology , Proteome*/genetics, Cell Size ; DNA Damage |
| مستخلص: | Cell size is tightly controlled in healthy tissues, but it is unclear how deviations in cell size affect cell physiology. To address this, we measured how the cell's proteome changes with increasing cell size. Size-dependent protein concentration changes are widespread and predicted by subcellular localization, size-dependent mRNA concentrations, and protein turnover. As proliferating cells grow larger, concentration changes typically associated with cellular senescence are increasingly pronounced, suggesting that large size may be a cause rather than just a consequence of cell senescence. Consistent with this hypothesis, larger cells are prone to replicative, DNA-damage-induced, and CDK4/6i-induced senescence. Size-dependent changes to the proteome, including those associated with senescence, are not observed when an increase in cell size is accompanied by an increase in ploidy. Together, our findings show how cell size could impact many aspects of cell physiology by remodeling the proteome and provide a rationale for cell size control and polyploidization. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
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| معلومات مُعتمدة: | F32 GM137522 United States GM NIGMS NIH HHS; R35 GM134858 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: DNA damage; SA-beta-Gal; cell cycle; cell size; p16(INK4); palbociclib; polyploidy; proteomics; senescence; size-scaling |
| المشرفين على المادة: | 0 (Proteome) |
| تواريخ الأحداث: | Date Created: 20220820 Date Completed: 20220908 Latest Revision: 20230902 |
| رمز التحديث: | 20230902 |
| مُعرف محوري في PubMed: | PMC9444988 |
| DOI: | 10.1016/j.molcel.2022.07.017 |
| PMID: | 35987199 |
| قاعدة البيانات: | MEDLINE |
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