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Disrupted development from head to tail: Pervasive effects of postnatal restricted resources on neurobiological, behavioral, and morphometric outcomes.

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العنوان: Disrupted development from head to tail: Pervasive effects of postnatal restricted resources on neurobiological, behavioral, and morphometric outcomes.
المؤلفون: Kent MH; Department of Biology, Virginia Military Institute, Lexington, VA, United States., Jacob JC; Department of Psychology, University of Richmond, Richmond, VA, United States., Bowen G; Department of Psychology, University of Richmond, Richmond, VA, United States., Bhalerao J; Department of Psychology, University of Richmond, Richmond, VA, United States., Desinor S; Department of Psychology, University of Richmond, Richmond, VA, United States., Vavra D; Department of Psychology, University of Richmond, Richmond, VA, United States., Leserve D; Department of Psychology, University of Richmond, Richmond, VA, United States., Ott KR; Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, United States., Angeles B; Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, United States., Martis M; Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, United States., Sciandra K; Department of Psychology, University of Richmond, Richmond, VA, United States., Gillenwater K; Department of Psychology, University of Richmond, Richmond, VA, United States., Glory C; Department of Psychology, University of Richmond, Richmond, VA, United States., Meisel E; Department of Psychology, University of Richmond, Richmond, VA, United States., Choe A; Department of Psychology, University of Richmond, Richmond, VA, United States., Olivares-Navarrete R; Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, United States., Puetzer JL; Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, United States., Lambert K; Department of Psychology, University of Richmond, Richmond, VA, United States.
المصدر: Frontiers in behavioral neuroscience [Front Behav Neurosci] 2022 Aug 05; Vol. 16, pp. 910056. Date of Electronic Publication: 2022 Aug 05 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477952 Publication Model: eCollection Cited Medium: Print ISSN: 1662-5153 (Print) Linking ISSN: 16625153 NLM ISO Abbreviation: Front Behav Neurosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Research Foundation, 2007-
مستخلص: When a maternal rat nurtures her pups, she relies on adequate resources to provide optimal care for her offspring. Accordingly, limited environmental resources may result in atypical maternal care, disrupting various developmental outcomes. In the current study, maternal Long-Evans rats were randomly assigned to either a standard resource (SR) group, provided with four cups of bedding and two paper towels for nesting material or a limited resource (LR) group, provided with a quarter of the bedding and nesting material provided for the SR group. Offspring were monitored at various developmental phases throughout the study. After weaning, pups were housed in same-sex dyads in environments with SRs for continued observations. Subsequent behavioral tests revealed a sex × resource interaction in play behavior on PND 28; specifically, LR reduced play attacks in males while LR increased play attacks in females. A sex × resource interaction was also observed in anxiety-related responses in the open field task with an increase in thigmotaxis in LR females and, in the social interaction task, females exhibited more external rears oriented away from the social target. Focusing on morphological variables, tail length measurements of LR males and females were shorter on PND 9, 16, and 21; however, differences in tail length were no longer present at PND 35. Following the behavioral assessments, animals were perfused at 56 days of age and subsequent immunohistochemical assays indicated increased glucocorticoid receptors in the lateral habenula of LR offspring and higher c-Fos immunoreactivity in the basolateral amygdala of SR offspring. Further, when tail vertebrae and tail tendons were assessed via micro-CT and hydroxyproline assays, results indicated increased trabecular separation, decreased bone volume fraction, and decreased connectivity density in bones, along with reduced collagen concentration in tendons in the LR animals. In sum, although the restricted resources only persisted for a brief duration, the effects appear to be far-reaching and pervasive in this early life stress animal model.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Kent, Jacob, Bowen, Bhalerao, Desinor, Vavra, Leserve, Ott, Angeles, Martis, Sciandra, Gillenwater, Glory, Meisel, Choe, Olivares-Navarrete, Puetzer and Lambert.)
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فهرسة مساهمة: Keywords: bone; early life stress; glucocorticoids; lateral habenula; maternal resource deprivation; postnatal development; rat
تواريخ الأحداث: Date Created: 20220822 Latest Revision: 20220823
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9389412
DOI: 10.3389/fnbeh.2022.910056
PMID: 35990727
قاعدة البيانات: MEDLINE
الوصف
تدمد:1662-5153
DOI:10.3389/fnbeh.2022.910056