دورية أكاديمية
Factors influencing the immune response over 15 months after SARS-CoV-2 infection: A longitudinal population-wide study in the Faroe Islands.
| العنوان: | Factors influencing the immune response over 15 months after SARS-CoV-2 infection: A longitudinal population-wide study in the Faroe Islands. |
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| المؤلفون: | Petersen MS; Department of Occupational Medicine and Public Health, The Faroese Hospital System, Tórshavn, Faroe Islands.; Centre of Health Science, University of the Faroe Islands, Tórshavn, Faroe Islands., Pérez-Alós L; Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Armenteros JJA; Department of Genetics, Stanford University School of Medicine, Stanford, California, USA., Hansen CB; Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Fjallsbak JP; Faroese Food and Veterinary Authority, Tórshavn, Faroe Islands., Larsen S; Faroese Food and Veterinary Authority, Tórshavn, Faroe Islands., Hansen JL; Faroese Food and Veterinary Authority, Tórshavn, Faroe Islands., Jarlhelt I; Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kristiansen MF; Centre of Health Science, University of the Faroe Islands, Tórshavn, Faroe Islands.; COVID-19 Task Force, Ministry of Health, Tórshavn, Faroe Islands.; Medical Department, National Hospital of the Faroe Islands, Tórshavn, Faroe Islands., Við Streym F; Department of Occupational Medicine and Public Health, The Faroese Hospital System, Tórshavn, Faroe Islands., Á Steig B; COVID-19 Task Force, Ministry of Health, Tórshavn, Faroe Islands.; Medical Department, National Hospital of the Faroe Islands, Tórshavn, Faroe Islands., Christiansen DH; Faroese Food and Veterinary Authority, Tórshavn, Faroe Islands., Møller LF; Chief Medical Office, Tórshavn, Faroe Islands., Strøm M; Centre of Health Science, University of the Faroe Islands, Tórshavn, Faroe Islands.; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Andorsdóttir G; The Genetic Biobank, Tórshavn, Faroe Islands., Gaini S; Centre of Health Science, University of the Faroe Islands, Tórshavn, Faroe Islands.; Medical Department, National Hospital of the Faroe Islands, Tórshavn, Faroe Islands.; Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Weihe P; Department of Occupational Medicine and Public Health, The Faroese Hospital System, Tórshavn, Faroe Islands.; Centre of Health Science, University of the Faroe Islands, Tórshavn, Faroe Islands., Garred P; Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. |
| المصدر: | Journal of internal medicine [J Intern Med] 2023 Jan; Vol. 293 (1), pp. 63-81. Date of Electronic Publication: 2022 Sep 01. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8904841 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2796 (Electronic) Linking ISSN: 09546820 NLM ISO Abbreviation: J Intern Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Blackwell Scientific Publications, c1989- |
| مواضيع طبية MeSH: | COVID-19*, Humans ; Male ; Longitudinal Studies ; SARS-CoV-2 ; Antibodies, Viral ; Antibodies, Neutralizing ; Immunoglobulin G ; Denmark ; Immunity |
| مستخلص: | Background: The durability of SARS-CoV-2 antibody response and the resulting immunity to COVID-19 is unclear. Objectives: To investigate long-term humoral immunity to SARS-CoV-2. Methods: In this nationwide, longitudinal study, we determined antibody response in 411 patients aged 0-93 years from two waves of infections (March to December 2020) contributing 1063 blood samples. Each individual had blood drawn on 4-5 occasions 1-15 months after disease onset. We measured total anti-SARS-CoV-2 receptor-binding domain (RBD) antibody using a qualitative RBD sandwich ELISA, IgM, IgG and IgA levels using an quantitative in-house ELISA-based assay and neutralizing antibodies (NAbs) using an in-house ELISA-based pseudoneutralizing assay. IgG subclasses were analyzed in a subset of samples by ELISA-based assay. We used nonlinear models to study the durability of SARS-CoV-2 antibody responses and its influence over time. Results: After 15 months, 94% still had detectable circulating antibodies, mainly the IgG isotype, and 92% had detectable NAbs. The distribution of IgG antibodies varied significantly over time, characterized by a biphasic pattern with an initial decline followed by a plateau after approximately 7 months. However, the NAbs remained relatively stable throughout the period. The strength of the antibody response was influenced by smoking and hospitalization, with lower IgG levels in smokers and higher levels in hospitalized individuals. Antibody stability over time was mainly associated with male sex and older age with higher initial levels but more marked decrease. Conclusions: The humoral immune response to SARS-CoV-2 infection varies depending on behavioral factors and disease severity, and antibody stability over 15 months was associated with sex and age. (© 2022 The Association for the Publication of the Journal of Internal Medicine.) |
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| فهرسة مساهمة: | Keywords: Faroe Islands; SARS-CoV-2 antibodies; infection-acquired immunity; longitudinal study; vaccination-acquired immunity |
| المشرفين على المادة: | 0 (Antibodies, Viral) 0 (Antibodies, Neutralizing) 0 (Immunoglobulin G) |
| تواريخ الأحداث: | Date Created: 20220823 Date Completed: 20221205 Latest Revision: 20230210 |
| رمز التحديث: | 20230210 |
| مُعرف محوري في PubMed: | PMC9539344 |
| DOI: | 10.1111/joim.13560 |
| PMID: | 35996938 |
| قاعدة البيانات: | MEDLINE |
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