دورية أكاديمية
Clinical efficacy of gouty tea on chronic gouty arthritis and its effects on serum vascular endothelial function and inflammatory cytokines.
| العنوان: | Clinical efficacy of gouty tea on chronic gouty arthritis and its effects on serum vascular endothelial function and inflammatory cytokines. |
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| المؤلفون: | Hua L; Department of Orthopedics, Haian Hospital of Traditional Chinese Medicine, Haian, China., Zhi-Gang C; Department of Orthopedics, Haian Hospital of Traditional Chinese Medicine, Haian, China., Hai-Lin B; Department of Medical Laboratory, Haian Hospital of Traditional Chinese Medicine, Haian, China., Ai-Chun W; Department of Orthopedics, Haian Hospital of Traditional Chinese Medicine, Haian, China., Xiao-Jian W; Department of Orthopedics, Haian Hospital of Traditional Chinese Medicine, Haian, China., Xiao-Lin F; Department of Endocrinology, Haian Hospital Affiliated to Nantong University, Haian, China., Wan-Hong LI; Department of Pharmacy, Haian Hospital of Traditional Chinese Medicine, Haian, China. |
| المصدر: | Pakistan journal of pharmaceutical sciences [Pak J Pharm Sci] 2022 Jul; Vol. 35 (4), pp. 999-1006. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Faculty of Pharmacy, University of Karachi Country of Publication: Pakistan NLM ID: 9426356 Publication Model: Print Cited Medium: Internet ISSN: 1011-601X (Print) Linking ISSN: 1011601X NLM ISO Abbreviation: Pak J Pharm Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Karachi : Faculty of Pharmacy, University of Karachi, [1988- |
| مواضيع طبية MeSH: | Arthritis, Gouty*/drug therapy, Cytokines ; Humans ; Tea ; Treatment Outcome ; Vascular Endothelial Growth Factor A ; von Willebrand Factor |
| مستخلص: | To observe the efficacy of Gouty Tea on chronic gouty arthritis and its effect on vascular endothelial function and inflammatory factor levels. Totally 120 patients with chronic gouty arthritis were divided into control group (allopurinol orally, 100 mg/time, tid, for 12 weeks) and observation group (Gouty Tea, 1 bag/time, tid, for 12 weeks) randomly (n=60 per group). Compared with those before treatment, the TCM symptom scores, visual analogue score (VAS) and the levels of UA and XOD of the two groups were reduced, while the levels of NO, ET-1, VEGF, vWF, CRP, IL-1β, TNF- α and NALP3 of the two groups improved, 6 and 12 weeks after treatment (P< 0.05). Nevertheless, after 6 weeks of treatment, there were no significantly difference of the level of VAS between the two groups. After 12 weeks of treatment, in the observation group, VAS was significantly lower compared to the control group. The TCM symptom scores and the levels of UA and XOD were significantly lower, while the levels of NO, ET-1, VEGF, vWF, CRP, IL-1β TNF- α and NALP3 were significantly better in the observation group than those of the control group 12 weeks after treatment (P< 0.05). The total effective rate was significantly higher and the incidence of adverse reactions was significantly lower in the observation group compared to the control group (P< 0.05). Gouty Tea can effectively reduce the UA, XOD levels and VAS, effectively improve the vascular endothelial function and inhibit the inflammation of patients. |
| المشرفين على المادة: | 0 (Cytokines) 0 (Tea) 0 (Vascular Endothelial Growth Factor A) 0 (von Willebrand Factor) |
| تواريخ الأحداث: | Date Created: 20220826 Date Completed: 20220829 Latest Revision: 20220829 |
| رمز التحديث: | 20221213 |
| PMID: | 36008895 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1011-601X |
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