دورية أكاديمية
أعرض في EDS

Enhanced In Vivo Wound Healing Efficacy of a Novel Hydrogel Loaded with Copper (II) Schiff Base Quinoline Complex (CuSQ) Solid Lipid Nanoparticles.

التفاصيل البيبلوغرافية
العنوان: Enhanced In Vivo Wound Healing Efficacy of a Novel Hydrogel Loaded with Copper (II) Schiff Base Quinoline Complex (CuSQ) Solid Lipid Nanoparticles.
المؤلفون: Abou El-Ezz D; Pharmacology Department, Faculty of Pharmacy, October University of Modern Sciences and Arts (MSA University), Cairo 12566, Egypt., Abdel-Rahman LH; Chemistry Department, Faculty of Science, Sohag University, Sohag 82534, Egypt., Al-Farhan BS; Chemistry Department, Faculty of Girls for Science, King Khalid University, Abha 61421, Saudi Arabia., Mostafa DA; Pharmaceutics Department, Faculty of Pharmacy, October University of Modern Sciences and Arts (MSA University), Cairo 12566, Egypt., Ayad EG; Chemistry Department, Faculty of Science, Helwan University, Cairo 11795, Egypt., Basha MT; Department of Chemistry, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia., Abdelaziz M; Pharmacology Department, Faculty of Pharmacy, October University of Modern Sciences and Arts (MSA University), Cairo 12566, Egypt., Abdalla EM; Chemistry Department, Faculty of Science, New Valley University, Alkharga 72511, Egypt.
المصدر: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2022 Aug 08; Vol. 15 (8). Date of Electronic Publication: 2022 Aug 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c2004-
مستخلص: Wound dressings created using nanotechnology are known as suitable substrates to speed up the healing of both acute and chronic wounds. Therapeutic substances can be delivered using these materials. In this study, a hydrogel loaded with Cu (II) Schiff base 8-hydroxy quinoline complex (CuSQ) solid lipid nanoparticles (SLN) was formulated to investigate its wound healing potential in an excision wound healing model in rats. The CuSQ SLN were spherical shaped with sizes ranging from 111 to 202 nm and a polydispersity index (PDI) ranging from 0.43 to 0.76, encapsulation efficiency (EE) % between 85 and 88, and zeta potential (ZP) of -11.8 to -40 mV. The formulated hydrogel showed good homogeneity, good stability, and a pH of 6.4 which indicates no skin irritation and had no cytotoxicity on the human skin fibroblast (HSF) cell line. In the in vivo study, animals were placed in five groups: control, standard, plain hydrogel, low dose, and high dose of CuSQ hydrogel. Both doses of CuSQ showed significantly faster healing rates compared to standard and control rats. In addition, the histopathology study showed more collagen, improved angiogenesis, and intact re-epithelization with less inflammation. A significant increase in transforming growth factor-beta1 (TGF-β1) level and increased immune expression of vascular endothelial growth factor (VEGF) by CuSQ treatment validates its role in collagen synthesis, proliferation of fibroblasts and enhancement of angiogenesis. Matrix metalloproteinase-9 (MMP-9) was found to be significantly reduced after CuSQ treatment. Immunohistochemistry of tumor necrosis factor alpha (TNF-α) revealed a marked decrease in inflammation. Thus, we concluded that CuSQ would be a beneficial drug for cutaneous wound healing since it effectively accelerated wound healing through regulation of various cytokines and growth factors.
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معلومات مُعتمدة: RGP.1/280/43 Deanship of Scientific Research at King Khalid University, Abha, Saudi Arabia
فهرسة مساهمة: Keywords: 8-hydroxy quinoline; copper Schiff base; hydrogel; solid lipid nanoparticles; wound healing
تواريخ الأحداث: Date Created: 20220826 Latest Revision: 20220830
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9416780
DOI: 10.3390/ph15080978
PMID: 36015126
قاعدة البيانات: MEDLINE
الوصف
تدمد:1424-8247
DOI:10.3390/ph15080978