دورية أكاديمية
أعرض في EDS

The Prognostic Value of Eight Immunohistochemical Markers Expressed in the Tumor Microenvironment and on Hodgkin Reed-Sternberg Cells in Pediatric Patients With Classical Hodgkin Lymphoma.

التفاصيل البيبلوغرافية
العنوان: The Prognostic Value of Eight Immunohistochemical Markers Expressed in the Tumor Microenvironment and on Hodgkin Reed-Sternberg Cells in Pediatric Patients With Classical Hodgkin Lymphoma.
المؤلفون: Zijtregtop EAM; Department of Hemato-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.; Department of Pediatric Hematology and Oncology, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, Netherlands., Tromp I; Department of Pediatric Hematology and Oncology, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, Netherlands., Dandis R; Department of Hemato-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Zwaan CM; Department of Hemato-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.; Department of Pediatric Hematology and Oncology, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, Netherlands., Lam KH; Department of Pathology, Erasmus Medical Center, Rotterdam, Netherlands., Meyer-Wentrup FAG; Department of Hemato-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Beishuizen A; Department of Hemato-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.; Department of Pediatric Hematology and Oncology, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, Netherlands.
المصدر: Pathology oncology research : POR [Pathol Oncol Res] 2022 Aug 11; Vol. 28, pp. 1610482. Date of Electronic Publication: 2022 Aug 11 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S. A Country of Publication: Switzerland NLM ID: 9706087 Publication Model: eCollection Cited Medium: Internet ISSN: 1532-2807 (Electronic) Linking ISSN: 12194956 NLM ISO Abbreviation: Pathol Oncol Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 2021- : Lausanne, Switzerland : Frontiers Media S. A.
Original Publication: Budapest, Hungary : Science Press, c1995-
مواضيع طبية MeSH: Hodgkin Disease* , Reed-Sternberg Cells*, Adult ; B7-H1 Antigen ; Biomarkers ; Child ; Humans ; Prognosis ; Tumor Microenvironment
مستخلص: Immunohistochemical markers are associated with treatment outcome in adults with classical Hodgkin Lymphoma (cHL). Studies in children are scarce and inconsistent. We investigated in 67 children with cHL, whether the expression of CD15, CD30, PAX5, PD-1, PD-L1, CD68, CD163 and TARC at diagnosis is associated with disease free survival (DFS) and with interim remission status. Low CD15 and low TARC expression were associated with relapsed disease. Low expression of PD-L1 was associated with complete remission at interim PET-scan. Our data suggest a difference between pediatric and adult cHL. This underlines the importance of future research into specific prognostic factors in pediatric cHL, indispensable for improvement of treatment in this population.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Zijtregtop, Tromp, Dandis, Zwaan, Lam, Meyer-Wentrup and Beishuizen.)
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فهرسة مساهمة: Keywords: children; classical Hodgkin lymphoma; immunohistochemical markers; pediatric; prognosis; prognostic markers; prognostic value
المشرفين على المادة: 0 (B7-H1 Antigen)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20220829 Date Completed: 20220830 Latest Revision: 20220830
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9402887
DOI: 10.3389/pore.2022.1610482
PMID: 36032657
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-2807
DOI:10.3389/pore.2022.1610482