دورية أكاديمية
أعرض في EDS

Fecal immunoglobulin A (IgA) and its subclasses in systemic lupus erythematosus patients are nuclear antigen reactive and this feature correlates with gut permeability marker levels.

التفاصيل البيبلوغرافية
العنوان: Fecal immunoglobulin A (IgA) and its subclasses in systemic lupus erythematosus patients are nuclear antigen reactive and this feature correlates with gut permeability marker levels.
المؤلفون: Gudi R; Microbiology and Immunology, College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA., Kamen D; Division of Rheumatology, Department of Medicine, College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA., Vasu C; Microbiology and Immunology, College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address: vasu@musc.edu.
المصدر: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2022 Sep; Vol. 242, pp. 109107. Date of Electronic Publication: 2022 Aug 29.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 100883537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-7035 (Electronic) Linking ISSN: 15216616 NLM ISO Abbreviation: Clin Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Orlando, FL : Academic Press, c1999-
مواضيع طبية MeSH: Immunoglobulin A* , Lupus Erythematosus, Systemic*, Antigens, Nuclear ; Biomarkers ; Feces ; Humans ; Permeability
مستخلص: Systemic lupus erythematosus (SLE) is characterized by the production of anti-nuclear autoantibodies. Here, for the first time, we show that the abundances of gut permeability marker Zonulin and IgA1- and IgA2- subclasses are significantly higher in the fecal samples of SLE patients compared to HCs. Importantly, IgA-total, and IgA1- and IgA2-subclasses from SLE patients showed higher nAg reactivity titers. Notably, we found that not only the nuclear antigen (nAg) reactive fecal IgA1:IgA2 ratio is higher in SLE patients, but also the abundance and nAg reactivity of fecal IgA and subclasses, IgA1 particularly, correlate with the fecal levels of Zonulin, which is produced primarily in the small intestine. These observations that higher amounts of nAg-reactive IgA and gut permeability marker are produced, particularly, in the proximal gut suggest a compromised epithelial barrier function and pro-inflammatory characteristics of small intestine in SLE patients.
Competing Interests: Declaration of Competing Interest Authors do not have any conflict(s) of interest to disclose.
(Copyright © 2022. Published by Elsevier Inc.)
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معلومات مُعتمدة: K24 AR068406 United States AR NIAMS NIH HHS; R01 AI138511 United States AI NIAID NIH HHS; R21 AI136339 United States AI NIAID NIH HHS; R21 AR067459 United States AR NIAMS NIH HHS
فهرسة مساهمة: Keywords: Immunoglobulin A; Intestinal inflammation markers; Nuclear antigen; Systemic lupus erythematosus
المشرفين على المادة: 0 (Antigens, Nuclear)
0 (Biomarkers)
0 (Immunoglobulin A)
تواريخ الأحداث: Date Created: 20220901 Date Completed: 20220913 Latest Revision: 20240114
رمز التحديث: 20240114
مُعرف محوري في PubMed: PMC10785702
DOI: 10.1016/j.clim.2022.109107
PMID: 36049603
قاعدة البيانات: MEDLINE
الوصف
تدمد:1521-7035
DOI:10.1016/j.clim.2022.109107