دورية أكاديمية
Influence of Renal Function on Phosphoramide Mustard Exposure: A Nonlinear Mixed-Effects Analysis.
العنوان: | Influence of Renal Function on Phosphoramide Mustard Exposure: A Nonlinear Mixed-Effects Analysis. |
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المؤلفون: | Jaber MM; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA., Takahashi T; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.; Boston Children's Hospital/Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Kirstein MN; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Al-Kofahi M; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA., Jacobson PA; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA., Brundage RC; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA. |
المصدر: | Journal of clinical pharmacology [J Clin Pharmacol] 2023 Jan; Vol. 63 (1), pp. 135-142. Date of Electronic Publication: 2022 Sep 29. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 0366372 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4604 (Electronic) Linking ISSN: 00912700 NLM ISO Abbreviation: J Clin Pharmacol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2013- : Oxford : Wiley Original Publication: Stamford, Conn., Hall Associates. |
مواضيع طبية MeSH: | Hematopoietic Stem Cell Transplantation*, Humans ; Phosphoramide Mustards/metabolism ; Cyclophosphamide ; Kidney/metabolism |
مستخلص: | Phosphoramide mustard (PM) is the final cytotoxic metabolite formed from the parent compound cyclophosphamide through a complex metabolic pathway, primarily through hepatic metabolism. Little is known about the effect of renal elimination on the disposition of PM. We evaluated the effect of renal function on PM exposure after single doses of cyclophosphamide in 85 patients undergoing allogeneic hematopoietic cell transplantation using nonlinear mixed-effects modeling. Mixed linear and nonlinear elimination pathways were required to adequately describe the disposition of PM. Creatinine clearance (CrCL) was incorporated as a covariate associated with first-order elimination, representing renal clearance (Cl (© 2022 Genentech Inc. The Journal of Clinical Pharmacology published by Wiley Periodicals LLC on behalf of American College of Clinical Pharmacology.) |
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فهرسة مساهمة: | Keywords: NONMEM; cyclophosphamide; nonlinear pharmacokinetics; phosphoramide mustard; population pharmacokinetics; renal function |
المشرفين على المادة: | 10159-53-2 (phosphoramide mustard) 0 (Phosphoramide Mustards) 8N3DW7272P (Cyclophosphamide) |
تواريخ الأحداث: | Date Created: 20220905 Date Completed: 20221215 Latest Revision: 20230413 |
رمز التحديث: | 20240829 |
مُعرف محوري في PubMed: | PMC10087276 |
DOI: | 10.1002/jcph.2144 |
PMID: | 36063026 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1552-4604 |
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DOI: | 10.1002/jcph.2144 |