دورية أكاديمية
أعرض في EDS

Whole-Genome Sequencing Reveals Diversity of Carbapenem-Resistant Pseudomonas aeruginosa Collected through CDC's Emerging Infections Program, United States, 2016-2018.

التفاصيل البيبلوغرافية
العنوان: Whole-Genome Sequencing Reveals Diversity of Carbapenem-Resistant Pseudomonas aeruginosa Collected through CDC's Emerging Infections Program, United States, 2016-2018.
المؤلفون: Stanton RA; Division of Healthcare Quality Promotion, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA., Campbell D; Division of Healthcare Quality Promotion, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA., McAllister GA; Division of Healthcare Quality Promotion, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA., Breaker E; Division of Healthcare Quality Promotion, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA., Adamczyk M; Division of Healthcare Quality Promotion, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA., Daniels JB; Division of Healthcare Quality Promotion, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA., Lutgring JD; Division of Healthcare Quality Promotion, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA., Karlsson M; Division of Healthcare Quality Promotion, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA., Schutz K; Colorado Department of Public Health and Environmentgrid.410375.4, Denver, Colorado, USA., Jacob JT; Emory Universitygrid.189967.8 School of Medicine, Atlanta, Georgia, USA.; Georgia Emerging Infections Program, Atlanta, Georgia, USA., Wilson LE; Maryland Department of Healthgrid.416491.f, Baltimore, Maryland, USA., Vaeth E; Maryland Department of Healthgrid.416491.f, Baltimore, Maryland, USA., Li L; Maryland Department of Healthgrid.416491.f, Baltimore, Maryland, USA., Lynfield R; Minnesota Department of Healthgrid.280248.4, St. Paul, Minnesota, USA., Snippes Vagnone PM; Minnesota Department of Healthgrid.280248.4, St. Paul, Minnesota, USA., Phipps EC; University of New Mexicogrid.266832.b, Albuquerque, New Mexico, USA.; New Mexico Emerging Infections Program, Santa Fe, New Mexico, USA., Hancock EB; University of New Mexicogrid.266832.b, Albuquerque, New Mexico, USA.; New Mexico Emerging Infections Program, Santa Fe, New Mexico, USA., Dumyati G; New York Rochester Emerging Infections Program at the University of Rochestergrid.16416.34 Medical Center, Rochester, New York, USA., Tsay R; New York Rochester Emerging Infections Program at the University of Rochestergrid.16416.34 Medical Center, Rochester, New York, USA., Cassidy PM; Oregon Health Authoritygrid.423217.1, Portland, Oregon, USA., Mounsey J; Tennessee Department of Public Health, Nashville, Tennessee, USA., Grass JE; Division of Healthcare Quality Promotion, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA., Bulens SN; Division of Healthcare Quality Promotion, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA., Walters MS; Division of Healthcare Quality Promotion, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.; Commissioned Corps, U.S. Public Health Service, Rockville, Maryland, USA., Halpin AL; Division of Healthcare Quality Promotion, Centers for Disease Control and Preventiongrid.416738.f, Atlanta, Georgia, USA.; Commissioned Corps, U.S. Public Health Service, Rockville, Maryland, USA.
المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2022 Sep 20; Vol. 66 (9), pp. e0049622. Date of Electronic Publication: 2022 Sep 06.
نوع المنشور: Journal Article; Research Support, U.S. Gov't, P.H.S.
اللغة: English
بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, American Society for Microbiology
مواضيع طبية MeSH: Pseudomonas Infections*/drug therapy , Pseudomonas Infections*/epidemiology , Pseudomonas aeruginosa*, Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Centers for Disease Control and Prevention, U.S. ; Humans ; Microbial Sensitivity Tests ; Multilocus Sequence Typing ; Porins/genetics ; United States/epidemiology ; beta-Lactamases/genetics ; beta-Lactamases/metabolism
مستخلص: The CDC's Emerging Infections Program (EIP) conducted population- and laboratory-based surveillance of US carbapenem-resistant Pseudomonas aeruginosa (CRPA) from 2016 through 2018. To characterize the pathotype, 1,019 isolates collected through this project underwent antimicrobial susceptibility testing and whole-genome sequencing. Sequenced genomes were classified using the seven-gene multilocus sequence typing (MLST) scheme and a core genome (cg)MLST scheme was used to determine phylogeny. Both chromosomal and horizontally transmitted mechanisms of carbapenem resistance were assessed. There were 336 sequence types (STs) among the 1,019 sequenced genomes, and the genomes varied by an average of 84.7% of the cgMLST alleles used. Mutations associated with dysfunction of the porin OprD were found in 888 (87.1%) of the genomes and were correlated with carbapenem resistance, and a machine learning model incorporating hundreds of genetic variations among the chromosomal mechanisms of resistance was able to classify resistant genomes. While only 7 (0.1%) isolates harbored carbapenemase genes, 66 (6.5%) had acquired non-carbapenemase β-lactamase genes, and these were more likely to have OprD dysfunction and be resistant to all carbapenems tested. The genetic diversity demonstrates that the pathotype includes a variety of strains, and clones previously identified as high-risk make up only a minority of CRPA strains in the United States. The increased carbapenem resistance in isolates with acquired non-carbapenemase β-lactamase genes suggests that horizontally transmitted mechanisms aside from carbapenemases themselves may be important drivers of the spread of carbapenem resistance in P. aeruginosa.
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فهرسة مساهمة: Keywords: Pseudomonas aeruginosa; antibiotic resistance; mechanisms of resistance; whole-genome sequencing
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Bacterial Proteins)
0 (Porins)
EC 3.5.2.6 (beta-Lactamases)
تواريخ الأحداث: Date Created: 20220906 Date Completed: 20220923 Latest Revision: 20230307
رمز التحديث: 20230307
مُعرف محوري في PubMed: PMC9487505
DOI: 10.1128/aac.00496-22
PMID: 36066241
قاعدة البيانات: MEDLINE
الوصف
تدمد:1098-6596
DOI:10.1128/aac.00496-22