دورية أكاديمية
Results of new-generation self-expanding transcatheter Porticoтм valve implantation in patients with degenerative aortic stenosis.
| العنوان: | Results of new-generation self-expanding transcatheter Porticoтм valve implantation in patients with degenerative aortic stenosis. |
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| المؤلفون: | Komlev AE; Chazov National Medical Research Centre of Cardiology., Imaev TE; Chazov National Medical Research Centre of Cardiology., Kolegaev AS; Chazov National Medical Research Centre of Cardiology., Lepilin PM; Chazov National Medical Research Centre of Cardiology., Makeev MI; Chazov National Medical Research Centre of Cardiology., Akchurin RS; Chazov National Medical Research Centre of Cardiology. |
| المصدر: | Kardiologiia [Kardiologiia] 2022 Aug 30; Vol. 62 (8), pp. 45-51. Date of Electronic Publication: 2022 Aug 30. |
| نوع المنشور: | Journal Article |
| اللغة: | Russian; English |
| بيانات الدورية: | Publisher: OOO Obshchestvo spet︠s︡ialistov po serdechnoĭ nedostatochnosti Country of Publication: Russia (Federation) NLM ID: 0376351 Publication Model: Electronic Cited Medium: Print ISSN: 0022-9040 (Print) Linking ISSN: 00229040 NLM ISO Abbreviation: Kardiologiia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2017->: Moskva : OOO Obshchestvo spet︠s︡ialistov po serdechnoĭ nedostatochnosti Original Publication: Moskva. |
| مواضيع طبية MeSH: | Aortic Valve Stenosis*/complications , Aortic Valve Stenosis*/diagnosis , Aortic Valve Stenosis*/surgery , Diabetes Mellitus, Type 2* , Heart Valve Prosthesis* , Heart Valve Prosthesis Implantation*/methods , Transcatheter Aortic Valve Replacement*/adverse effects, Aged ; Aged, 80 and over ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Female ; Humans ; Male ; Prospective Studies ; Stroke Volume ; Treatment Outcome ; Ventricular Function, Left |
| مستخلص: | Aim To evaluate 30-day results of the transcatheter correction of degenerative aortic stenosis using a novel self-expandable valve, PorticoTM.Material and methods Transcatheter aortic valve implantation (TAVI) was performed in 42 patients with an intermediate surgical risk (mean age, 74.3±6.5 years, 8 men, 34 women, EuroSCORE II risk, 2.5 (1.5;4.1)) with severe degenerative aortic stenosis (AS). 20 (48 %) patients had ischemic heart disease; 8 (19%) of patients had atrial fibrillation, and 16 (38%) of patients had type 2 diabetes mellitus. Most of the patients (88 %) had preserved systolic function, and 5 patients had a pronounced decrease in left ventricular ejection fraction. Early efficacy and safety of the intervention were evaluated with VARC-2 criteria.Results In-hospital and 30-day mortality following TAVI was absent. Also, there were no adverse events, including cerebrovascular disorders, perioperative myocardial infarction, and conversion to open surgery. One patient had prosthesis migration to the aorta, which required implantation of the second self-expandable valve. Mean duration of the procedure was 90 min (80;110), fluoroscopy time was 21 min (19;24), and contrast volume 154 ml (200;240). Following TAVI, the mean aortic valve (AV) pressure gradient significantly decreased from 56.1±21.2 to 11.2±4.0 mm Hg, the maximal gradient decreased from 88.9±27.8 to 20.0±7.0 mm Hg, and the AV effective orifice area increased from 0.67±0.2 to 1.9±0.3 cm2 (p<0.001). By the time of discharge from the hospital, all patients showed regression of AS clinical manifestations. The percentage of patients with NYHA functional class III chronic heart failure reduced from 62 % to 7 % (p<0.001) after TAVI. In one case after the implantation, grade 3 aortic regurgitation was observed, which required endovascular occlusion to close the paraprosthetic fistula. Moderate paraprosthetic regurgitation (grade <2) was observed in 3 (7 %) patients. Only 2 (4.8%) patients required permanent pacemaker implantation.Conclusion Results of the single-center prospective TAVI study using a novel self-expandable valve Porticoтм showed satisfactory hemodynamic parameters, efficacy and safety of the procedure for the 30-day follow-up period. A relatively low radial force of the carcass can be beneficial for reducing the incidence of permanent pacemaker implantation after TAVI. |
| تواريخ الأحداث: | Date Created: 20220906 Date Completed: 20220908 Latest Revision: 20220908 |
| رمز التحديث: | 20240829 |
| DOI: | 10.18087/cardio.2022.8.n1923 |
| PMID: | 36066987 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0022-9040 |
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| DOI: | 10.18087/cardio.2022.8.n1923 |