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Microglial infiltration mediates cognitive dysfunction in rat models of hypothalamic obesity via a hypothalamic-hippocampal circuit involving the lateral hypothalamic area.

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العنوان: Microglial infiltration mediates cognitive dysfunction in rat models of hypothalamic obesity via a hypothalamic-hippocampal circuit involving the lateral hypothalamic area.
المؤلفون: Song C; Department of Neurosurgery, The Central Hospital of Dalian University of Technology, Dalian, China.; Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China., Wei W; Department of Neurosurgery, The Central Hospital of Dalian University of Technology, Dalian, China., Wang T; Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Department of Neurosurgery, The Third Hospital of Mianyang (Sichuan Mental Health Center), Mianyang, China., Zhou M; Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China., Li Y; The First School of Clinical Medicine, Southern Medical University, Guangzhou, China., Xiao B; The First School of Clinical Medicine, Southern Medical University, Guangzhou, China., Huang D; The First School of Clinical Medicine, Southern Medical University, Guangzhou, China., Gu J; Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China., Shi L; Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China., Peng J; Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China., Jin D; Department of Neurosurgery, The Central Hospital of Dalian University of Technology, Dalian, China.
المصدر: Frontiers in cellular neuroscience [Front Cell Neurosci] 2022 Aug 22; Vol. 16, pp. 971100. Date of Electronic Publication: 2022 Aug 22 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477935 Publication Model: eCollection Cited Medium: Print ISSN: 1662-5102 (Print) Linking ISSN: 16625102 NLM ISO Abbreviation: Front Cell Neurosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Research Foundation, 2007-
مستخلص: This study aimed to explore the mechanism underlying cognitive dysfunction mediated by the lateral hypothalamic area (LHA) in a hypothalamic-hippocampal circuit in rats with lesion-induced hypothalamic obesity (HO). The HO model was established by electrically lesioning the hypothalamic nuclei. The open field (OP) test, Morris water maze (MWM), novel object recognition (NOR), and novel object location memory (NLM) tests were used to evaluate changes in cognition due to alterations in the hypothalamic-hippocampal circuit. Western blotting, immunohistochemical staining, and cholera toxin subunit B conjugated with Alexa Fluor 488 (CTB488) reverse tracer technology were used to determine synaptophysin (SYN), postsynaptic density protein 95 (PSD95), ionized calcium binding adaptor molecule 1 (Iba1), neuronal nuclear protein (NeuN), and Caspase3 expression levels and the hypothalamic-hippocampal circuit. In HO rats, severe obesity was associated with cognitive dysfunction after the lesion of the hypothalamus. Furthermore, neuronal apoptosis and activated microglia in the downstream of the lesion area (the LHA) induced microglial infiltration into the intact hippocampus via the LHA-hippocampal circuit, and the synapses engulfment in the hippocampus may be the underlying mechanism by which the remodeled microglial mediates memory impairments in HO rats. The HO rats exhibited microglial infiltration and synapse loss into the hippocampus from the lesioned LHA via the hypothalamic-hippocampal circuit. The underlying mechanisms of memory function may be related to the circuit.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Song, Wei, Wang, Zhou, Li, Xiao, Huang, Gu, Shi, Peng and Jin.)
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فهرسة مساهمة: Keywords: hypothalamic obesity; lateral hypothalamic area; memory dysfunction; microglial cells; neural circuits
تواريخ الأحداث: Date Created: 20220908 Latest Revision: 20220910
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC9443213
DOI: 10.3389/fncel.2022.971100
PMID: 36072565
قاعدة البيانات: MEDLINE
الوصف
تدمد:1662-5102
DOI:10.3389/fncel.2022.971100