دورية أكاديمية
COVID-19-Associated Hospitalizations Among Vaccinated and Unvaccinated Adults 18 Years or Older in 13 US States, January 2021 to April 2022.
| العنوان: | COVID-19-Associated Hospitalizations Among Vaccinated and Unvaccinated Adults 18 Years or Older in 13 US States, January 2021 to April 2022. |
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| المؤلفون: | Havers FP; US Centers for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia.; Public Health Service Commissioned Corps, Rockville, Maryland., Pham H; US Centers for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia., Taylor CA; US Centers for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia., Whitaker M; US Centers for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia., Patel K; US Centers for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia.; General Dynamics Information Technology, Atlanta, Georgia., Anglin O; US Centers for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia.; General Dynamics Information Technology, Atlanta, Georgia., Kambhampati AK; US Centers for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia., Milucky J; US Centers for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia., Zell E; US Centers for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia.; Stat-Epi Associates, Inc, Ponte Vedra Beach, Florida., Moline HL; US Centers for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia.; Public Health Service Commissioned Corps, Rockville, Maryland., Chai SJ; Field Services Branch, Division of State and Local Readiness, Center for Preparedness and Response, US Centers for Disease Control and Prevention, Atlanta, Georgia.; California Emerging Infections Program, Oakland., Kirley PD; California Emerging Infections Program, Oakland., Alden NB; Colorado Department of Public Health and Environment, Denver., Armistead I; Colorado Department of Public Health and Environment, Denver., Yousey-Hindes K; Connecticut Emerging Infections Program, Yale School of Public Health, New Haven., Meek J; Connecticut Emerging Infections Program, Yale School of Public Health, New Haven., Openo KP; Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, Georgia.; Georgia Emerging Infections Program, Georgia Department of Public Health, Atlanta., Anderson EJ; Georgia Emerging Infections Program, Georgia Department of Public Health, Atlanta.; Departments of Medicine and Pediatrics, Emory School of Medicine, Atlanta, Georgia.; Atlanta Veterans Affairs Medical Center, Atlanta, Georgia., Reeg L; Michigan Department of Health and Human Services, Lansing., Kohrman A; Michigan Department of Health and Human Services, Lansing., Lynfield R; Minnesota Department of Health, St. Paul., Como-Sabetti K; Minnesota Department of Health, St. Paul., Davis EM; New Mexico Department of Health, Santa Fe., Cline C; New Mexico Department of Health, Santa Fe., Muse A; New York State Department of Health, Albany., Barney G; New York State Department of Health, Albany., Bushey S; University of Rochester School of Medicine and Dentistry, Rochester, New York., Felsen CB; University of Rochester School of Medicine and Dentistry, Rochester, New York., Billing LM; Ohio Department of Health, Columbus., Shiltz E; Ohio Department of Health, Columbus., Sutton M; Public Health Division, Oregon Health Authority, Portland., Abdullah N; Public Health Division, Oregon Health Authority, Portland., Talbot HK; Vanderbilt University Medical Center, Nashville, Tennessee., Schaffner W; Vanderbilt University Medical Center, Nashville, Tennessee., Hill M; Salt Lake County Health Department, Salt Lake City, Utah., George A; Salt Lake County Health Department, Salt Lake City, Utah., Hall AJ; US Centers for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia., Bialek SR; US Centers for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia.; Public Health Service Commissioned Corps, Rockville, Maryland., Murthy NC; US Centers for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia.; Public Health Service Commissioned Corps, Rockville, Maryland., Murthy BP; US Centers for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia.; Public Health Service Commissioned Corps, Rockville, Maryland., McMorrow M; US Centers for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia.; Public Health Service Commissioned Corps, Rockville, Maryland. |
| المصدر: | JAMA internal medicine [JAMA Intern Med] 2022 Oct 01; Vol. 182 (10), pp. 1071-1081. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Medical Association Country of Publication: United States NLM ID: 101589534 Publication Model: Print Cited Medium: Internet ISSN: 2168-6114 (Electronic) Linking ISSN: 21686106 NLM ISO Abbreviation: JAMA Intern Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Chicago, IL : American Medical Association, [2013]- |
| مواضيع طبية MeSH: | COVID-19*/epidemiology , COVID-19*/prevention & control , Influenza Vaccines*, Adult ; Aged ; COVID-19 Vaccines ; Cross-Sectional Studies ; Hospitalization ; Humans ; SARS-CoV-2 |
| مستخلص: | Importance: Understanding risk factors for hospitalization in vaccinated persons and the association of COVID-19 vaccines with hospitalization rates is critical for public health efforts to control COVID-19. Objective: To determine characteristics of COVID-19-associated hospitalizations among vaccinated persons and comparative hospitalization rates in unvaccinated and vaccinated persons. Design, Setting, and Participants: From January 1, 2021, to April 30, 2022, patients 18 years or older with laboratory-confirmed SARS-CoV-2 infection were identified from more than 250 hospitals in the population-based COVID-19-Associated Hospitalization Surveillance Network. State immunization information system data were linked to cases, and the vaccination coverage data of the defined catchment population were used to compare hospitalization rates in unvaccinated and vaccinated individuals. Vaccinated and unvaccinated patient characteristics were compared in a representative sample with detailed medical record review; unweighted case counts and weighted percentages were calculated. Exposures: Laboratory-confirmed COVID-19-associated hospitalization, defined as a positive SARS-CoV-2 test result within 14 days before or during hospitalization. Main Outcomes and Measures: COVID-19-associated hospitalization rates among vaccinated vs unvaccinated persons and factors associated with COVID-19-associated hospitalization in vaccinated persons were assessed. Results: Using representative data from 192 509 hospitalizations (see Table 1 for demographic information), monthly COVID-19-associated hospitalization rates ranged from 3.5 times to 17.7 times higher in unvaccinated persons than vaccinated persons regardless of booster dose status. From January to April 2022, when the Omicron variant was predominant, hospitalization rates were 10.5 times higher in unvaccinated persons and 2.5 times higher in vaccinated persons with no booster dose, respectively, compared with those who had received a booster dose. Among sampled cases, vaccinated hospitalized patients with COVID-19 were older than those who were unvaccinated (median [IQR] age, 70 [58-80] years vs 58 [46-70] years, respectively; P < .001) and more likely to have 3 or more underlying medical conditions (1926 [77.8%] vs 4124 [51.6%], respectively; P < .001). Conclusions and Relevance: In this cross-sectional study of US adults hospitalized with COVID-19, unvaccinated adults were more likely to be hospitalized compared with vaccinated adults; hospitalization rates were lowest in those who had received a booster dose. Hospitalized vaccinated persons were older and more likely to have 3 or more underlying medical conditions and be long-term care facility residents compared with hospitalized unvaccinated persons. The study results suggest that clinicians and public health practitioners should continue to promote vaccination with all recommended doses for eligible persons. |
| References: | MMWR Morb Mortal Wkly Rep. 2022 Mar 25;71(12):466-473. (PMID: 35324880) MMWR Morb Mortal Wkly Rep. 2022 Jan 07;71(1):19-25. (PMID: 34990440) MMWR Morb Mortal Wkly Rep. 2020 Apr 17;69(15):458-464. (PMID: 32298251) JAMA. 2021 Nov 23;326(20):2043-2054. (PMID: 34734975) Clin Infect Dis. 2022 Dec 19;75(12):2161-2168. (PMID: 35511586) MMWR Morb Mortal Wkly Rep. 2022 Feb 18;71(7):271-278. (PMID: 35176003) N Engl J Med. 2022 Mar 17;386(11):1094. (PMID: 35172053) MMWR Morb Mortal Wkly Rep. 2021 Aug 13;70(32):1088-1093. (PMID: 34383730) MMWR Morb Mortal Wkly Rep. 2021 Nov 05;70(44):1545-1552. (PMID: 34735422) MMWR Morb Mortal Wkly Rep. 2022 Aug 26;71(34):1085-1091. (PMID: 36006841) Ann Intern Med. 2021 Oct;174(10):1409-1419. (PMID: 34370517) N Engl J Med. 2022 Apr 14;386(15):1397-1408. (PMID: 35172054) Clin Microbiol Infect. 2021 Nov;27(11):1652-1657. (PMID: 34245907) JAMA Netw Open. 2021 Oct 1;4(10):e2130479. (PMID: 34673962) medRxiv. 2021 Jul 08;:. (PMID: 34268515) MMWR Morb Mortal Wkly Rep. 2021 Sep 17;70(37):1294-1299. (PMID: 34529636) N Engl J Med. 2021 Jul 22;385(4):320-329. (PMID: 34192428) |
| معلومات مُعتمدة: | UL1 TR001863 United States TR NCATS NIH HHS |
| المشرفين على المادة: | 0 (COVID-19 Vaccines) 0 (Influenza Vaccines) |
| SCR Organism: | SARS-CoV-2 variants |
| تواريخ الأحداث: | Date Created: 20220908 Date Completed: 20221005 Latest Revision: 20231102 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC9459904 |
| DOI: | 10.1001/jamainternmed.2022.4299 |
| PMID: | 36074486 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2168-6114 |
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| DOI: | 10.1001/jamainternmed.2022.4299 |