دورية أكاديمية
أعرض في EDS

A Randomized Trial of the Effects of Dietary n3-PUFAs on Skeletal Muscle Function and Acute Exercise Response in Healthy Older Adults.

التفاصيل البيبلوغرافية
العنوان: A Randomized Trial of the Effects of Dietary n3-PUFAs on Skeletal Muscle Function and Acute Exercise Response in Healthy Older Adults.
المؤلفون: Kunz HE; Endocrine Research Unit, Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA., Michie KL; Endocrine Research Unit, Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA., Gries KJ; Endocrine Research Unit, Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.; Department of Physical Therapy, School of Health Professions, Concordia University of Wisconsin, Mequon, WI 53097, USA., Zhang X; Endocrine Research Unit, Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.; Department of Geriatrics, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, China., Ryan ZC; Endocrine Research Unit, Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA., Lanza IR; Endocrine Research Unit, Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
المصدر: Nutrients [Nutrients] 2022 Aug 27; Vol. 14 (17). Date of Electronic Publication: 2022 Aug 27.
نوع المنشور: Journal Article; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Fatty Acids, Omega-3*, Aged ; Dietary Supplements ; Exercise ; Humans ; Inflammation/metabolism ; Muscle Strength ; Muscle, Skeletal/metabolism
مستخلص: Skeletal muscle is critical for maintaining mobility, independence, and metabolic health in older adults. However, a common feature of aging is the progressive loss of skeletal muscle mass and function, which is often accompanied by mitochondrial impairments, oxidative stress, and insulin resistance. Exercise improves muscle strength, mitochondrial health, and cardiorespiratory fitness, but older adults often exhibit attenuated anabolic responses to acute exercise. Chronic inflammation associated with aging may contribute to this "anabolic resistance" and therapeutic interventions that target inflammation may improve exercise responsiveness. To this end, we conducted a randomized controlled trial to determine the effect of 6 months of dietary omega-3 polyunsaturated fatty acids (n3-PUFA) supplementation on skeletal muscle function (mass, strength), mitochondrial physiology (respiration, ATP production, ROS generation), and acute exercise responsiveness at the level of the muscle (fractional synthesis rate) and the whole-body (amino acid kinetics) in healthy older adults. When compared with a corn oil placebo ( n = 33; 71.5 ± 4.8 years), older adults treated with 4 g/day n3-PUFA ( n = 30; 71.4 ± 4.5 years) exhibited modest but significant increases in muscle strength (3.1 ± 14.7% increase in placebo vs. 7.5 ± 14.1% increase in n3-PUFA; p = 0.039). These improvements in muscle strength with n3-PUFA supplementation occurred in the absence of any effects on mitochondrial function and a minor attenuation of the acute response to exercise compared to placebo. Together, these data suggest modest benefits of dietary n3-PUFAs to muscle function in healthy older adults. Future studies may elucidate whether n3-PUFA supplementation improves the exercise response in elderly individuals with co-morbidities, such as chronic inflammatory disease or sarcopenia.
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معلومات مُعتمدة: T32DK007352 United States DK NIDDK NIH HHS; DK116231 United States TR NCATS NIH HHS; T32AR56950 United States AR NIAMS NIH HHS; T32 DK007352 United States DK NIDDK NIH HHS; UL1 TR002377 United States TR NCATS NIH HHS; R01 AG054454 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: aging; anabolic resistance; exercise; n3-PUFA
المشرفين على المادة: 0 (Fatty Acids, Omega-3)
تواريخ الأحداث: Date Created: 20220909 Date Completed: 20220912 Latest Revision: 20230324
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9459748
DOI: 10.3390/nu14173537
PMID: 36079794
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu14173537