دورية أكاديمية
Cardiovascular Outcomes in Kidney Transplant Recipients With ADPKD.
| العنوان: | Cardiovascular Outcomes in Kidney Transplant Recipients With ADPKD. |
|---|---|
| المؤلفون: | Chedid M; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Kaidbay HD; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.; Lebanese American University, Gilbert and Rose-Mary Chagoury school of medicine, Byblos, Lebanon., Wigerinck S; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Mkhaimer Y; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Smith B; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA., Zubidat D; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Sekhon I; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Prajwal R; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA., Duriseti P; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Issa N; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.; William J Von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, Minnesota, USA., Zoghby ZM; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Hanna C; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.; Division of Pediatric Nephrology and Hypertension, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA., Senum SR; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Harris PC; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.; Department of biochemistry and molecular biology, Mayo Clinic, Rochester, Minnesota, USA., Hickson LJ; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida, USA., Torres VE; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Nkomo VT; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA., Chebib FT; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida, USA. |
| المصدر: | Kidney international reports [Kidney Int Rep] 2022 Jun 11; Vol. 7 (9), pp. 1991-2005. Date of Electronic Publication: 2022 Jun 11 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101684752 Publication Model: eCollection Cited Medium: Internet ISSN: 2468-0249 (Electronic) Linking ISSN: 24680249 NLM ISO Abbreviation: Kidney Int Rep Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Philadelphia] : Elsevier, [2016]- |
| مستخلص: | Introduction: Cardiovascular disease leads to high morbidity and mortality in patients with kidney failure. Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a systemic disease with various cardiac abnormalities. Details on the cardiovascular profile of patients with ADPKD who are undergoing kidney transplantation (KT) and its progression are limited. Methods: Echocardiographic data within 2 years before KT (1993-2020), and major adverse cardiovascular events (MACEs) after transplantation were retrieved. The primary outcome is to assess cardiovascular abnormalities on echocardiography at the time of transplantation in ADPKD as compared with patients without ADPKD matched by sex (male, 59.4%) and age at transplantation (57.2 ± 8.8 years). Results: Compared with diabetic nephropathy (DN, n = 271) and nondiabetic, patients without ADPKD (NDNA) ( n = 271) at the time of KT, patients with ADPKD ( n = 271) had lower rates of left ventricular hypertrophy (LVH) (39.4% vs. 66.4% vs. 48.6%), mitral (2.7% vs. 6.3% vs. 7.45) and tricuspid regurgitations (1.8% vs. 6.6% vs. 7.2%). Patients with ADPKD had less diastolic (25.3%) and systolic (5.6%) dysfunction at time of transplantation. Patients with ADPKD had the most favorable post-transplantation survival (median 18.7 years vs. 12.0 for diabetic nephropathy [DN] and 13.8 years for nondiabetic non-ADPKD [NDNA]; P < 0.01) and the most favorable MACE-free survival rate (hazard ratio = 0.51, P < 0.001). Patients with ADPKD had worsening of their valvular function and an increase in the sinus of Valsalva diameter post-transplantation (38.2 vs. 39.9 mm, P < 0.01). Conclusion: ADPKD transplant recipients have the most favorable cardiac profile pretransplantation with better patient survival and MACE-free survival rates but worsening valvular function and increasing sinus of Valsalva diameter, as compared with patients with other kidney diseases. (© 2022 International Society of Nephrology. Published by Elsevier Inc.) |
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| معلومات مُعتمدة: | R01 DK058816 United States DK NIDDK NIH HHS |
| فهرسة مساهمة: | Keywords: ADPKD; MACE; cardiovascular outcome; echocardiogram; kidney transplantation; valvular disease |
| تواريخ الأحداث: | Date Created: 20220912 Latest Revision: 20231130 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9459062 |
| DOI: | 10.1016/j.ekir.2022.06.006 |
| PMID: | 36090485 |
| قاعدة البيانات: | MEDLINE |
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