دورية أكاديمية
Association between chemosensory dysfunctions and inflammatory biomarkers in patients with SARS-CoV-2 infection: a systematic review and meta-analysis.
| العنوان: | Association between chemosensory dysfunctions and inflammatory biomarkers in patients with SARS-CoV-2 infection: a systematic review and meta-analysis. |
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| المؤلفون: | de Melo EGM; Graduate Program in Dentistry, Hospital Universitário, Federal University of Sergipe, Rua Cláudio Batista, s/n. Sanatório, Aracaju, Sergipe, CEP: 49060-100, Brazil.; Investigative Pathology Laboratory, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Andrade RM; Graduate Program in Dentistry, Hospital Universitário, Federal University of Sergipe, Rua Cláudio Batista, s/n. Sanatório, Aracaju, Sergipe, CEP: 49060-100, Brazil.; Investigative Pathology Laboratory, Federal University of Sergipe, Aracaju, Sergipe, Brazil., de Abreu de Vasconcellos SJ; Tiradentes University, Aracaju, Sergipe, Brazil., Dos Santos PL; Graduate Program in Applied Health Sciences, Federal University of Sergipe, Lagarto, Sergipe, Brazil.; Graduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Tanajura DM; Investigative Pathology Laboratory, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Quintans-Júnior LJ; Graduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil.; Laboratory of Neurosciences and Pharmacological Assays, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil., Quintans JSS; Graduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil.; Laboratory of Neurosciences and Pharmacological Assays, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil., Martins-Filho PR; Graduate Program in Dentistry, Hospital Universitário, Federal University of Sergipe, Rua Cláudio Batista, s/n. Sanatório, Aracaju, Sergipe, CEP: 49060-100, Brazil. prmartinsfh@gmail.com.; Graduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil. prmartinsfh@gmail.com.; Investigative Pathology Laboratory, Federal University of Sergipe, Aracaju, Sergipe, Brazil. prmartinsfh@gmail.com. |
| المصدر: | Inflammopharmacology [Inflammopharmacology] 2022 Dec; Vol. 30 (6), pp. 2079-2087. Date of Electronic Publication: 2022 Sep 12. |
| نوع المنشور: | Meta-Analysis; Systematic Review; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9112626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-5608 (Electronic) Linking ISSN: 09254692 NLM ISO Abbreviation: Inflammopharmacology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Basel ; Boston : Birkhäuser Original Publication: Dordrecht, The Netherlands ; Norwell, MA, USA : Kluwer Academic Publishers, c1991- |
| مواضيع طبية MeSH: | COVID-19* , Olfaction Disorders*/etiology , Olfaction Disorders*/diagnosis , Skin Diseases*, Humans ; SARS-CoV-2 ; Taste Disorders/diagnosis ; Biomarkers |
| مستخلص: | Background: There is evidence that chemosensory dysfunctions, including smell and taste disorders, are common findings in patients with SARS-CoV-2 infection. However, the underlying biological mechanisms and the role of inflammatory markers are still poorly understood. Aim: To investigate the inflammatory biomarkers levels in patients with COVID-19 presenting chemosensory dysfunctions. Methods: This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. A systematic literature search was performed from January 1, 2020, to May 12, 2022. Observational studies that provided data on hematological, biochemical, infection-related indices and cellular immunity, and coagulation function in patients with COVID-19 experiencing smell and/or taste disorders were considered eligible. Effect sizes were reported as standardized mean difference (SMD) with 95% confidence intervals (CI). A negative effect size indicated that the inflammatory biomarker levels were lower among patients with chemosensory dysfunctions. Results: Eleven studies were included. Patients with chemosensory disturbances had lower levels of leukocytes (SMD - 0.18, 95% CI - 0.35 to - 0.01, p = 0.04), lactate dehydrogenase (SMD - 0.45, 95% CI - 0.82 to - 0.09, p = 0.01), IL-6 (SMD - 0.25, 95% CI - 0.44 to - 0.06, p < 0.01), and C-reactive protein (SMD - 0.33, 95% CI - 0.58 to - 0.08, p < 0.01) than patients without chemosensory disturbances. Conclusion: Patients with SARS-CoV-2 infection who have olfactory and gustatory disorders have a lower inflammatory response than patients who do not have chemosensory alterations. The presence of these symptoms may indicate a more favorable clinical course for COVID-19. (© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.) |
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| معلومات مُعتمدة: | Finance Code 001 CAPES; 88881.157445/2017-01 Edital CAPES/FAPITEC n.11/2016 - PROEF |
| فهرسة مساهمة: | Keywords: Ageusia; Anosmia; COVID-19; Cytokines; Inflammation mediators; Olfaction disorders; SARS-CoV-2 infection; Taste disorders |
| المشرفين على المادة: | 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20220913 Date Completed: 20221129 Latest Revision: 20221130 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC9467422 |
| DOI: | 10.1007/s10787-022-01066-z |
| PMID: | 36097300 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1568-5608 |
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| DOI: | 10.1007/s10787-022-01066-z |