دورية أكاديمية
Mass Spectrometry Metabolomics Approach Reveals Anti-Trichomonas vaginalis Scaffolds from Marine Fungi.
| العنوان: | Mass Spectrometry Metabolomics Approach Reveals Anti-Trichomonas vaginalis Scaffolds from Marine Fungi. |
|---|---|
| المؤلفون: | Endres CT; Faculdade de Farmácia and Centro de Biotecnologia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil., Rigo GV; Faculdade de Farmácia and Centro de Biotecnologia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil., Loges LA; Faculdade de Farmácia and Centro de Biotecnologia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil., Landell MF; Laboratório de Diversidade Molecular, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., Silva DB; Laboratório de Produtos Naturais E Espectrometria de Massas (LaPNEM), Faculdade de Ciências Farmacêuticas, Alimentos E Nutrição (FACFAN), Universidade Federal de Mato Grosso Do Sul, Mato Grosso Do Sul, Campo Grande, Brazil., Macedo AJ; Faculdade de Farmácia and Centro de Biotecnologia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil. alexandre.macedo@ufrgs.br., Tasca T; Faculdade de Farmácia and Centro de Biotecnologia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil. |
| المصدر: | Marine biotechnology (New York, N.Y.) [Mar Biotechnol (NY)] 2022 Oct; Vol. 24 (5), pp. 1014-1022. Date of Electronic Publication: 2022 Sep 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag New York Inc Country of Publication: United States NLM ID: 100892712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1436-2236 (Electronic) Linking ISSN: 14362228 NLM ISO Abbreviation: Mar Biotechnol (NY) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Springer-Verlag New York Inc., c1999- |
| مواضيع طبية MeSH: | Biological Products* , Citrinin* , Trichomonas vaginalis*, Fungi ; Mass Spectrometry ; Metronidazole/pharmacology ; Plant Extracts |
| مستخلص: | Trichomoniasis is the most common non-viral sexually transmitted infection (STI) in the world caused by Trichomonas vaginalis. Failures in the treatment with the 5-nitroimidazole class including parasite resistance to metronidazole elicit new alternatives. Marine natural products are sources of several relevant molecules, presenting a variety of metabolites with numerous biological activities. In this work, we evaluated the anti-T. vaginalis activity of fungi associated with marine invertebrates by mass spectrometry-based metabolomics approaches. After screening of six marine fungi, extract from Penicillium citrinum FMPV 15 has shown to be 100% active against T. vaginalis, and the gel permeation column on Sephadex LH-20® yielded twelve organic fractions which five showed to be active. Metabolomics and statistical analyses were performed with all the samples (extract and fractions), and several compounds were suggested to be related to the activity. These components include citrinin, dicitrinin C, citreoisocoumarin, dihydrocitrinone, decarboxycitrinin, penicitrinone C, and others. The minimum inhibitory concentration (MIC) value of anti-T. vaginalis activity of citrinin was 200 µM. The marine fungi metabolites show potential as new alternatives to overcome drug resistance in T. vaginalis infections. (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| معلومات مُعتمدة: | #408578/2013-0 Conselho Nacional de Desenvolvimento Científico e Tecnológico; #408718/2013-7 Conselho Nacional de Desenvolvimento Científico e Tecnológico; #428538/2018-5 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 16/2551-0000244-4 Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul |
| فهرسة مساهمة: | Keywords: Citrinin; Marine fungi; Marine metabolites; Metabolomics; Penicillium citrinum; Trichomonas vaginalis |
| المشرفين على المادة: | 0 (Biological Products) 0 (Plant Extracts) 140QMO216E (Metronidazole) 3S697X6SNZ (Citrinin) |
| تواريخ الأحداث: | Date Created: 20220914 Date Completed: 20221017 Latest Revision: 20221017 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s10126-022-10164-6 |
| PMID: | 36102994 |
| قاعدة البيانات: | MEDLINE |
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