دورية أكاديمية
Deep neural networks allow expert-level brain meningioma segmentation and present potential for improvement of clinical practice.
العنوان: | Deep neural networks allow expert-level brain meningioma segmentation and present potential for improvement of clinical practice. |
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المؤلفون: | Boaro A; Computational Neuroscience Outcomes Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. alessandro.boaro@univr.it.; Section of Neurosurgery, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy. alessandro.boaro@univr.it., Kaczmarzyk JR; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Medical Scientist Training Program, Stony Brook University School of Medicine, Stony Brook, NY, USA., Kavouridis VK; Computational Neuroscience Outcomes Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Harary M; Computational Neuroscience Outcomes Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurosurgery, University of California Los Angeles, Los Angeles, CA, USA., Mammi M; Computational Neuroscience Outcomes Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Dawood H; Computational Neuroscience Outcomes Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Shea A; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Cho EY; Computational Neuroscience Outcomes Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Juvekar P; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Noh T; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Rana A; Computational Neuroscience Outcomes Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Ghosh S; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA. satra@mit.edu., Arnaout O; Computational Neuroscience Outcomes Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. |
المصدر: | Scientific reports [Sci Rep] 2022 Sep 14; Vol. 12 (1), pp. 15462. Date of Electronic Publication: 2022 Sep 14. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
مواضيع طبية MeSH: | Deep Learning* , Meningeal Neoplasms*/diagnostic imaging , Meningioma*/diagnostic imaging, Brain/diagnostic imaging ; Humans ; Neural Networks, Computer |
مستخلص: | Accurate brain meningioma segmentation and volumetric assessment are critical for serial patient follow-up, surgical planning and monitoring response to treatment. Current gold standard of manual labeling is a time-consuming process, subject to inter-user variability. Fully-automated algorithms for meningioma segmentation have the potential to bring volumetric analysis into clinical and research workflows by increasing accuracy and efficiency, reducing inter-user variability and saving time. Previous research has focused solely on segmentation tasks without assessment of impact and usability of deep learning solutions in clinical practice. Herein, we demonstrate a three-dimensional convolutional neural network (3D-CNN) that performs expert-level, automated meningioma segmentation and volume estimation on MRI scans. A 3D-CNN was initially trained by segmenting entire brain volumes using a dataset of 10,099 healthy brain MRIs. Using transfer learning, the network was then specifically trained on meningioma segmentation using 806 expert-labeled MRIs. The final model achieved a median performance of 88.2% reaching the spectrum of current inter-expert variability (82.6-91.6%). We demonstrate in a simulated clinical scenario that a deep learning approach to meningioma segmentation is feasible, highly accurate and has the potential to improve current clinical practice. (© 2022. The Author(s).) |
References: | JAMA. 2016 Dec 13;316(22):2402-2410. (PMID: 27898976) Neuro Oncol. 2019 Feb 14;21(2):234-241. (PMID: 30085283) Nat Biomed Eng. 2018 Oct;2(10):719-731. (PMID: 31015651) Med Image Anal. 2017 Feb;36:61-78. (PMID: 27865153) Neurosurgery. 2012 Jun;70(6):1504-18; discussion 1518-9. (PMID: 22240812) J Neurooncol. 2019 Apr;142(2):211-221. (PMID: 30656531) Med Image Anal. 2017 Jan;35:18-31. (PMID: 27310171) Neuroinformatics. 2021 Jul;19(3):393-402. (PMID: 32974873) Radiographics. 2017 Nov-Dec;37(7):2113-2131. (PMID: 29131760) Eur J Radiol. 2019 Jul;116:128-134. (PMID: 31153553) Nat Med. 2019 Jan;25(1):24-29. (PMID: 30617335) Acta Neurochir (Wien). 2018 Aug;160(8):1547-1553. (PMID: 29876678) Neuroimage. 2017 Jan;144(Pt B):262-269. (PMID: 26375206) Neuroimage. 2012 Aug 15;62(2):774-81. (PMID: 22248573) J Magn Reson Imaging. 2019 Oct;50(4):1152-1159. (PMID: 30896065) Neurosurgery. 2011 Jun;68(6):1632-47; discussion 1647. (PMID: 21368690) Nature. 2015 May 28;521(7553):436-44. (PMID: 26017442) J Neurosurg. 2011 May;114(5):1250-6. (PMID: 21250802) Nat Rev Cancer. 2018 Aug;18(8):500-510. (PMID: 29777175) Nature. 2017 Feb 2;542(7639):115-118. (PMID: 28117445) BMC Med Inform Decis Mak. 2011 Aug 26;11:54. (PMID: 21871082) BMC Med Imaging. 2015 Aug 12;15:29. (PMID: 26263899) J Neurol. 2008 Jun;255(6):891-5. (PMID: 18350353) Med Image Anal. 2012 Jul;16(5):933-51. (PMID: 22465077) Mol Psychiatry. 2014 Jun;19(6):659-67. (PMID: 23774715) Int J Clin Exp Pathol. 2012;5(3):231-42. (PMID: 22558478) Neuro Oncol. 2018 Oct 1;20(suppl_4):iv1-iv86. (PMID: 30445539) IEEE Trans Med Imaging. 2015 Oct;34(10):1993-2024. (PMID: 25494501) Eur Radiol. 2019 Jan;29(1):124-132. (PMID: 29943184) J Neurosurg. 2011 Aug;115(2):259-67. (PMID: 21529132) J Digit Imaging. 2017 Aug;30(4):449-459. (PMID: 28577131) World Neurosurg. 2018 Mar;111:e149-e159. (PMID: 29248774) Acta Neurochir (Wien). 2018 Jan;160(1):29-38. (PMID: 29134342) Nat Med. 2019 Jan;25(1):30-36. (PMID: 30617336) PLoS Med. 2018 Nov 30;15(11):e1002707. (PMID: 30500815) |
معلومات مُعتمدة: | R01EB020740 United States EB NIBIB NIH HHS; T32GM008444 United States GM NIGMS NIH HHS; RF1 MH121885 United States MH NIMH NIH HHS; P41 EB019936 United States EB NIBIB NIH HHS; RF1MH121885 United States MH NIMH NIH HHS |
تواريخ الأحداث: | Date Created: 20220914 Date Completed: 20220916 Latest Revision: 20230701 |
رمز التحديث: | 20240829 |
مُعرف محوري في PubMed: | PMC9474556 |
DOI: | 10.1038/s41598-022-19356-5 |
PMID: | 36104424 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2045-2322 |
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DOI: | 10.1038/s41598-022-19356-5 |