دورية أكاديمية
أعرض في EDS

Control of cell state transitions.

التفاصيل البيبلوغرافية
العنوان: Control of cell state transitions.
المؤلفون: Rukhlenko OS; Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland., Halasz M; Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland.; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland., Rauch N; Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland., Zhernovkov V; Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland., Prince T; Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland., Wynne K; Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland., Maher S; Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland., Kashdan E; Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland., MacLeod K; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Carragher NO; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Kolch W; Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland.; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland., Kholodenko BN; Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland. boris.kholodenko@ucd.ie.; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland. boris.kholodenko@ucd.ie.; Department of Pharmacology, Yale University School of Medicine, New Haven, USA. boris.kholodenko@ucd.ie.
المصدر: Nature [Nature] 2022 Sep; Vol. 609 (7929), pp. 975-985. Date of Electronic Publication: 2022 Sep 14.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
أسماء مطبوعة: Publication: Basingstoke : Nature Publishing Group
Original Publication: London, Macmillan Journals ltd.
مواضيع طبية MeSH: Cell Differentiation* , Models, Biological* , Signal Transduction*, Cell Proliferation ; Datasets as Topic ; Phenotype ; Single-Cell Analysis ; Workflow
مستخلص: Understanding cell state transitions and purposefully controlling them is a longstanding challenge in biology. Here we present cell state transition assessment and regulation (cSTAR), an approach for mapping cell states, modelling transitions between them and predicting targeted interventions to convert cell fate decisions. cSTAR uses omics data as input, classifies cell states, and develops a workflow that transforms the input data into mechanistic models that identify a core signalling network, which controls cell fate transitions by influencing whole-cell networks. By integrating signalling and phenotypic data, cSTAR models how cells manoeuvre in Waddington's landscape 1 and make decisions about which cell fate to adopt. Notably, cSTAR devises interventions to control the movement of cells in Waddington's landscape. Testing cSTAR in a cellular model of differentiation and proliferation shows a high correlation between quantitative predictions and experimental data. Applying cSTAR to different types of perturbation and omics datasets, including single-cell data, demonstrates its flexibility and scalability and provides new biological insights. The ability of cSTAR to identify targeted perturbations that interconvert cell fates will enable designer approaches for manipulating cellular development pathways and mechanistically underpinned therapeutic interventions.
(© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
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معلومات مُعتمدة: 28596 United Kingdom CRUK_ Cancer Research UK; MR/R015635/1 United Kingdom MRC_ Medical Research Council; R01 CA244660 United States CA NCI NIH HHS
تواريخ الأحداث: Date Created: 20220914 Date Completed: 20220930 Latest Revision: 20240306
رمز التحديث: 20240306
مُعرف محوري في PubMed: PMC9644236
DOI: 10.1038/s41586-022-05194-y
PMID: 36104561
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-4687
DOI:10.1038/s41586-022-05194-y