دورية أكاديمية
Effects of resveratrol topical ointment on wound healing of full-thickness cutaneous burns in albino rats.
| العنوان: | Effects of resveratrol topical ointment on wound healing of full-thickness cutaneous burns in albino rats. |
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| المؤلفون: | Yoksa DT; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Maiduguri, PMB 1069 Maiduguri, Borno State., Abba Y; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Maiduguri, PMB 1069 Maiduguri, Borno State., Shamaki BU; Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Maiduguri, PMB 1069 Maiduguri, Borno State., Satumari NA; Department of Medical Laboratory Science, Faculty of Allied Health Sciences, University of Maiduguri, PMB 1069 Maiduguri, Borno State. |
| المصدر: | Journal of wound care [J Wound Care] 2022 Sep 02; Vol. 31 (9), pp. 780-791. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MA Healthcare Country of Publication: England NLM ID: 9417080 Publication Model: Print Cited Medium: Internet ISSN: 0969-0700 (Print) Linking ISSN: 09690700 NLM ISO Abbreviation: J Wound Care |
| أسماء مطبوعة: | Publication: London : MA Healthcare Original Publication: Ruislip, UK : Journal of Wound Care, |
| مواضيع طبية MeSH: | Burns*/therapy , Soft Tissue Injuries*, Collagen/pharmacology ; Formaldehyde/pharmacology ; Humans ; Ointments ; Rats ; Resveratrol/pharmacology ; Silver Sulfadiazine/pharmacology ; Silver Sulfadiazine/therapeutic use ; Wound Healing ; Animals |
| مستخلص: | Objective: In this study, the effects of resveratrol topical ointment on wound contraction and histopathology of full-thickness cutaneous burn wounds were evaluated. Method: Adult albino rats were grouped into four equal-sized groups of 15 rats each, as follows: Group A-no wound, no treatment (control); Group B-1% silver sulphadiazine; Group C-5% resveratrol, and Group D-wound without treatment (control). A burn wound measuring 23.5mm was created on the skin at the dorsum of all rats in groups B-D after shaving. The percentage of wound contraction was measured using a digital Vernier Caliper on days 1, 3, 5, 7, 10, 14, 16, 18 and 21, post-wounding. From each group, five rats were then euthanised and tissue samples of the skin, liver and kidney were collected in 10% buffered formalin for histopathology. Results: The percentage of wound contraction was significant (p<0.05) on 7, 14 and 18 days post treatment. Histopathologically, 5% resveratrol topical ointment application resulted in a thicker epidermis with neovascularisation and an increased collagen distribution. Resveratrol topical ointment ameliorated the extent of hepatocellular and nephrotubular injuries following burn-induced hepatocellular and acute kidney injuries. Conclusion: In this study, topical application of 5% resveratrol ointment appeared to enhance burn wound healing by increasing the rate of wound contraction through collagen fibre synthesis, granulation tissue formation and epithelial regeneration. |
| فهرسة مساهمة: | Keywords: burn; collagen; contraction; fibrosis; granulation; resveratrol; topical ointment; wound; wound care; wound contraction; wound healing |
| المشرفين على المادة: | 0 (Ointments) 1HG84L3525 (Formaldehyde) 9007-34-5 (Collagen) Q369O8926L (Resveratrol) W46JY43EJR (Silver Sulfadiazine) |
| تواريخ الأحداث: | Date Created: 20220916 Date Completed: 20220920 Latest Revision: 20240304 |
| رمز التحديث: | 20240304 |
| DOI: | 10.12968/jowc.2022.31.9.780 |
| PMID: | 36113542 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0969-0700 |
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| DOI: | 10.12968/jowc.2022.31.9.780 |