دورية أكاديمية
أعرض في EDS

Association of Red Cell Index and Adverse Hospitalization Outcomes in Chronic Obstructive Pulmonary Disease Patients with Acute Exacerbation: A Retrospective Cohort Study.

التفاصيل البيبلوغرافية
العنوان: Association of Red Cell Index and Adverse Hospitalization Outcomes in Chronic Obstructive Pulmonary Disease Patients with Acute Exacerbation: A Retrospective Cohort Study.
المؤلفون: Yuan FZ; Department of General Practice Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China., Shui W; Department of General Medicine, The Eastern Hospital of the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China., Xing YL; Department of General Medicine, The Eastern Hospital of the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China., Niu YY; Department of General Medicine, The Eastern Hospital of the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China., Zhang X; Department of General Medicine, The Eastern Hospital of the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China., Zhang CR; Department of General Medicine, The Eastern Hospital of the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
المصدر: International journal of chronic obstructive pulmonary disease [Int J Chron Obstruct Pulmon Dis] 2022 Sep 15; Vol. 17, pp. 2263-2275. Date of Electronic Publication: 2022 Sep 15 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101273481 Publication Model: eCollection Cited Medium: Internet ISSN: 1178-2005 (Electronic) Linking ISSN: 11769106 NLM ISO Abbreviation: Int J Chron Obstruct Pulmon Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Auckland, N.Z. : DOVE Medical Press,
مواضيع طبية MeSH: Pulmonary Disease, Chronic Obstructive*/diagnosis , Pulmonary Disease, Chronic Obstructive*/epidemiology , Pulmonary Disease, Chronic Obstructive*/therapy, Disease Progression ; Erythrocyte Indices ; Hospitalization ; Humans ; Logistic Models ; Retrospective Studies
مستخلص: Purpose: Previous studies have shown that the red cell index (RCI) can be considered as a simple and useful method to evaluate respiratory function. However, at present its association with adverse hospitalization outcomes in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is not fully understood. Our study aimed to examine the relationship between adverse hospitalization outcomes and RCI among AECOPD patients.
Patients and Methods: We performed a retrospective analysis of consecutive patients from January 2015 to October 2021. In this study, RCI was the independent variable, measured at baseline, and adverse hospitalization outcome was the dependent variable. According to the RCI median (RCI=2.221), we divided 377 patients into two roughly equal groups (188 and 189, respectively). Next, the association between RCI and adverse hospitalization outcomes was explored using multivariable logistic regression models. To identify any non-linear relationship, a generalized additive model (GAM) was employed.
Results: With a total of 377 patients with AECOPD, we divided them into two roughly equal groups to compare the clinical factors and RCI levels. The patients in the higher RCI group showed poorer outcome incidence (18 [9.57%] vs 31 [16.40%]; p = 0.049). After accounting for potential confounders, the results showed that RCI was positively associated with adverse hospitalization outcomes (odds ratio [OR] = 1.15, 95% CI: 1.01-1.32). In addition, a non-linear relationship was detected between RCI and adverse hospitalization outcomes, which had an inflection point of 3.2. There were odds ratios and confidence intervals of 0.8 (0.7-1.0) and 1.3 (1.2-1.4) on the left and right sides of the inflection point, respectively.
Conclusion: The RCI and adverse hospitalization outcomes exhibited a non-linear relationship in the AECOPD patients. RCI is strongly positively correlated with adverse hospitalization outcomes when it was greater than 3.2.
Competing Interests: No competing interests are declared by the authors.
(© 2022 Yuan et al.)
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فهرسة مساهمة: Keywords: AECOPD; RCI; non-linearity; worse hospitalization outcomes
تواريخ الأحداث: Date Created: 20220922 Date Completed: 20220923 Latest Revision: 20221019
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9484768
DOI: 10.2147/COPD.S373114
PMID: 36133737
قاعدة البيانات: MEDLINE
الوصف
تدمد:1178-2005
DOI:10.2147/COPD.S373114