دورية أكاديمية
أعرض في EDS

Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality.

التفاصيل البيبلوغرافية
العنوان: Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality.
المؤلفون: Wattrus SJ; Howard Hughes Medical Institute, Boston Children's Hospital Boston, MA, USA.; Harvard Stem Cell Institute, Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA, USA., Smith ML; Howard Hughes Medical Institute, Boston Children's Hospital Boston, MA, USA.; Harvard Stem Cell Institute, Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA, USA., Rodrigues CP; Howard Hughes Medical Institute, Boston Children's Hospital Boston, MA, USA.; Harvard Stem Cell Institute, Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA, USA., Hagedorn EJ; Howard Hughes Medical Institute, Boston Children's Hospital Boston, MA, USA.; Harvard Stem Cell Institute, Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA, USA., Kim JW; Howard Hughes Medical Institute, Boston Children's Hospital Boston, MA, USA.; Harvard Stem Cell Institute, Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA, USA., Budnik B; Mass Spectrometry and Proteomics Resource Laboratory, Faculty of Arts and Sciences Division of Science, Harvard University, Cambridge, MA, USA., Zon LI; Howard Hughes Medical Institute, Boston Children's Hospital Boston, MA, USA.; Harvard Stem Cell Institute, Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA, USA.
المصدر: Science (New York, N.Y.) [Science] 2022 Sep 23; Vol. 377 (6613), pp. 1413-1419. Date of Electronic Publication: 2022 Sep 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
أسماء مطبوعة: Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-
مواضيع طبية MeSH: Apoptosis* , Calreticulin*/genetics , Calreticulin*/metabolism , Cell Communication* , Clonal Hematopoiesis*/genetics , Clonal Hematopoiesis*/physiology , Hematopoietic Stem Cells*/physiology , Macrophages*/physiology, Animals ; Calbindin 2/genetics ; Calbindin 2/physiology ; Embryo, Nonmammalian ; Zebrafish ; Zebrafish Proteins/genetics ; Zebrafish Proteins/physiology
مستخلص: Tissue-specific stem cells persist for a lifetime and can differentiate to maintain homeostasis or transform to initiate cancer. Despite their importance, there are no described quality assurance mechanisms for newly formed stem cells. We observed intimate and specific interactions between macrophages and nascent blood stem cells in zebrafish embryos. Macrophage interactions frequently led to either removal of cytoplasmic material and stem cell division or complete engulfment and stem cell death. Stressed stem cells were marked by surface Calreticulin, which stimulated macrophage interactions. Using cellular barcoding, we found that Calreticulin knock-down or embryonic macrophage depletion reduced the number of stem cell clones that established adult hematopoiesis. Our work supports a model in which embryonic macrophages determine hematopoietic clonality by monitoring stem cell quality.
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Comment in: Trends Immunol. 2022 Dec;43(12):950-952. doi: 10.1016/j.it.2022.10.008. (PMID: 36307308)
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معلومات مُعتمدة: U01 HL134812 United States HL NHLBI NIH HHS; R01 HL144780 United States HL NHLBI NIH HHS; K01 DK111790 United States DK NIDDK NIH HHS; F31 HL149154 United States HL NHLBI NIH HHS; P01 HL032262 United States HL NHLBI NIH HHS; P01 HL131477 United States HL NHLBI NIH HHS; RC2 DK120535 United States DK NIDDK NIH HHS; United States HHMI Howard Hughes Medical Institute; T32 HL007574 United States HL NHLBI NIH HHS; R24 OD017870 United States OD NIH HHS; U54 DK110805 United States DK NIDDK NIH HHS; R24 DK092760 United States DK NIDDK NIH HHS
المشرفين على المادة: 0 (Calbindin 2)
0 (Calreticulin)
0 (Zebrafish Proteins)
0 (calb2b protein, zebrafish)
تواريخ الأحداث: Date Created: 20220922 Date Completed: 20220926 Latest Revision: 20240905
رمز التحديث: 20240905
مُعرف محوري في PubMed: PMC9524573
DOI: 10.1126/science.abo4837
PMID: 36137040
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-9203
DOI:10.1126/science.abo4837