دورية أكاديمية
أعرض في EDS

Optical Coherence Tomography Significance in Managing Early Onset of Optic Pathway Gliomas in Children Younger than 5 Years of Age-A Retrospective Study.

التفاصيل البيبلوغرافية
العنوان: Optical Coherence Tomography Significance in Managing Early Onset of Optic Pathway Gliomas in Children Younger than 5 Years of Age-A Retrospective Study.
المؤلفون: Pavone R; Neuro-Oncology Unit, Department of Pediatric Oncology, Meyer Children's Hospital, 50134 Florence, Italy., Fonte C; Neuro-Oncology Unit, Department of Pediatric Oncology, Meyer Children's Hospital, 50134 Florence, Italy., Sardi I; Neuro-Oncology Unit, Department of Pediatric Oncology, Meyer Children's Hospital, 50134 Florence, Italy., Caputo R; Pediatric Ophthalmology Unit, Meyer Children's Hospital, Viale Pieraccini 24, 50134 Florence, Italy., Marziali E; Pediatric Ophthalmology Unit, Meyer Children's Hospital, Viale Pieraccini 24, 50134 Florence, Italy., Mazzeo F; Pediatric Ophthalmology Unit, Meyer Children's Hospital, Viale Pieraccini 24, 50134 Florence, Italy., Secci J; Pediatric Ophthalmology Unit, Meyer Children's Hospital, Viale Pieraccini 24, 50134 Florence, Italy., Bergamini A; Pediatric Ophthalmology Unit, Meyer Children's Hospital, Viale Pieraccini 24, 50134 Florence, Italy., De Masi S; Clinical Trial Center, Careggi Hospital, 50134 Florence, Italy., Leo MC; Clinical Research and Study Design Office, Meyer Children's Hospital, 50134 Florence, Italy., Censullo ML; Neuro-Oncology Unit, Department of Pediatric Oncology, Meyer Children's Hospital, 50134 Florence, Italy., Bacci GM; Pediatric Ophthalmology Unit, Meyer Children's Hospital, Viale Pieraccini 24, 50134 Florence, Italy.
المصدر: Children (Basel, Switzerland) [Children (Basel)] 2022 Aug 28; Vol. 9 (9). Date of Electronic Publication: 2022 Aug 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101648936 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9067 (Print) Linking ISSN: 22279067 NLM ISO Abbreviation: Children (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2014]-
مستخلص: We aimed to investigate the significance of optical coherence tomography (SD-OCT) in managing pediatric optic pathway gliomas (OPGs) in children younger than 5 years of age. A retrospective monocentric study was conducted. SD-OCT scans were obtained using the handheld iVue system to assess peripapillary retinal nerve fibre layer (pRNFL) thickness at three time points: baseline (OCT1), end of treatment (OCT2), and at last follow-up (OCT3). We compared the median value of pRNFL (and interquartile range-IQR) at different follow-up times and in different sub-groups (stable disease-SD, partial response-PR, and progression disease-PD). Thirteen children younger than 5 years of age were included. The Median follow-up time was 3.9 years (IQR 1.2). Six patients showed a pRNFL change of more than 10% during follow-up. Seven patients showed PD during follow-up. Median pRNFL at baseline was 81.5 µm (IQR 31.5); median pRNFL at the end of treatment was 73 µm (IQR 33); median pRNFL at last follow-up was 72 µm (IQR 38.5). The mean pRNFL at baseline was significantly lower than the mean normative values. Only subjects with PD showed pRNFL change close to statistical significance. This study confirms the role of SD-OCT in managing OPGs for therapeutic decisions and strategy planning of visual rehabilitation.
References: J AAPOS. 2015 Dec;19(6):531-4. (PMID: 26691032)
Acta Ophthalmol. 2018 Dec;96(8):e1004-e1009. (PMID: 30284379)
Br J Radiol. 2008 Oct;81(970):761-6. (PMID: 18796556)
JAMA Ophthalmol. 2014 Mar;132(3):265-71. (PMID: 24435762)
Dev Med Child Neurol. 2021 Oct;63(10):1180-1193. (PMID: 34813110)
Graefes Arch Clin Exp Ophthalmol. 2013 Oct;251(10):2429-36. (PMID: 23736991)
Neurosurg Focus. 2007;23(5):E2. (PMID: 18004964)
Genet Med. 2021 Aug;23(8):1506-1513. (PMID: 34012067)
J Child Neurol. 2003 Jul;18(7):471-8. (PMID: 12940652)
Ophthalmology. 2007 Jun;114(6):1046-52. (PMID: 17210181)
PLoS One. 2021 Jul 1;16(7):e0253720. (PMID: 34197499)
Acta Neuropathol. 2000 May;99(5):563-70. (PMID: 10805102)
Neuro Oncol. 2012 Jun;14(6):790-7. (PMID: 22474213)
Ophthalmology. 2012 Apr;119(4):731-7. (PMID: 22264886)
PLoS One. 2021 Dec 23;16(12):e0261631. (PMID: 34941930)
Neuropediatrics. 2015 Apr;46(2):88-97. (PMID: 25803824)
AMA Arch Neurol Psychiatry. 1958 Jun;79(6):607-21. (PMID: 13532071)
Am J Ophthalmol. 2013 Feb;155(2):354-360.e1. (PMID: 23127751)
Am J Ophthalmol. 2015 Nov;160(5):944-952.e1. (PMID: 26231306)
Invest Ophthalmol Vis Sci. 2013 Dec 17;54(13):8112-8. (PMID: 24169000)
Neuro Oncol. 2007 Oct;9(4):430-7. (PMID: 17704361)
Ann Neurol. 2007 Mar;61(3):189-98. (PMID: 17387725)
فهرسة مساهمة: Keywords: OPG; SD-OCT; neurofibromatosis; optic pathway glioma; optical coherence tomography; pRNFL
تواريخ الأحداث: Date Created: 20220923 Latest Revision: 20220928
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9497564
DOI: 10.3390/children9091307
PMID: 36138616
قاعدة البيانات: MEDLINE
الوصف
تدمد:2227-9067
DOI:10.3390/children9091307