دورية أكاديمية
Modifiable Innate Biology within the Gut-Brain Axis for Alzheimer's Disease.
| العنوان: | Modifiable Innate Biology within the Gut-Brain Axis for Alzheimer's Disease. |
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| المؤلفون: | Marcos Pasero H; Bioactivity and Nutritional Immunology Group (BIOINUT), Faculty of Health Sciences, Universidad Internacional de Valencia-VIU, Pintor Sorolla 21, 46002 Valencia, Spain., García Tejedor A; Bioactivity and Nutritional Immunology Group (BIOINUT), Faculty of Health Sciences, Universidad Internacional de Valencia-VIU, Pintor Sorolla 21, 46002 Valencia, Spain., Giménez-Bastida JA; Laboratory of Food and Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, Department Food Science and Technology, CEBAS-CSIC, Campus de Espinardo, 30100 Murcia, Spain., Laparra Llopis JM; Molecular Immunonutrition Group, Madrid Institute for Advanced Studies in Food (IMDEA Food), Ctra Cantoblanco 8, 28049 Madrid, Spain. |
| المصدر: | Biomedicines [Biomedicines] 2022 Aug 27; Vol. 10 (9). Date of Electronic Publication: 2022 Aug 27. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, [2013]- |
| مستخلص: | Alzheimer's disease (AD) is a prototypical inflammation-associated loss of cognitive function, with approximately 90% of the AD burden associated with invading myeloid cells controlling the function of the resident microglia. This indicates that the immune microenvironment has a pivotal role in the pathogenesis of the disease. Multiple peripheral stimuli, conditioned by complex and varied interactions between signals that stem at the intestinal level and neuroimmune processes, are involved in the progression and severity of AD. Conceivably, the targeting of critical innate immune signals and cells is achievable, influencing immune and metabolic health within the gut-brain axis. Considerable progress has been made, modulating many different metabolic and immune alterations that can drive AD development. However, non-pharmacological strategies targeting immunometabolic processes affecting neuroinflammation in AD treatment remain general and, at this point, are applied to all patients regardless of disease features. Despite these possibilities, improved knowledge of the relative contribution of the different innate immune cells and molecules comprising the chronically inflamed brain network to AD pathogenesis, and elucidation of the network hierarchy, are needed for planning potent preventive and/or therapeutic interventions. Moreover, an integrative perspective addressing transdisciplinary fields can significantly contribute to molecular pathological epidemiology, improving the health and quality of life of AD patients. This review is intended to gather modifiable immunometabolic processes based on their importance in the prevention and management of AD. |
| References: | Front Aging Neurosci. 2020 Feb 13;12:17. (PMID: 32116650) Alzheimers Dement (N Y). 2020 Oct 22;6(1):e12089. (PMID: 33117881) Nat Rev Neurol. 2012 Aug;8(8):411. (PMID: 22801972) Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):136-146. (PMID: 30391544) J Alzheimers Dis. 2017;59(1):291-300. (PMID: 28598847) Curr Diabetes Rev. 2019;15(4):255-258. (PMID: 30381082) Front Pharmacol. 2018 Apr 20;9:386. (PMID: 29731715) Biomedicines. 2021 Nov 06;9(11):. (PMID: 34829862) Alzheimers Res Ther. 2021 Feb 23;13(1):51. (PMID: 33622392) J Neural Transm (Vienna). 2010 Aug;117(8):949-60. (PMID: 20552234) EBioMedicine. 2018 Nov;37:461-470. (PMID: 30314892) Arterioscler Thromb Vasc Biol. 2020 Jan;40(1):86-102. (PMID: 31597445) Front Chem. 2020 Oct 23;8:573297. (PMID: 33195062) Endocrinology. 2019 May 1;160(5):1021-1030. (PMID: 30807635) Mol Nutr Food Res. 2021 Mar;65(6):e2000660. (PMID: 33141510) Biochem J. 2012 Jan 15;441(2):675-83. (PMID: 21970364) Mol Psychiatry. 2021 Oct;26(10):5504-5515. (PMID: 33854189) Immun Ageing. 2021 Jun 21;18(1):29. (PMID: 34154615) Nat Commun. 2013;4:1829. (PMID: 23652017) Nat Rev Neurol. 2018 Nov;14(11):667-675. (PMID: 30266932) Nat Rev Immunol. 2015 Aug;15(8):511-23. (PMID: 26139350) FASEB J. 2017 May;31(5):1867-1878. (PMID: 28096231) Int J Mol Sci. 2022 Apr 25;23(9):. (PMID: 35563135) Eur J Pharmacol. 2019 Jan 5;842:208-220. (PMID: 30389631) Sleep. 2005 Nov;28(11):1412-7. (PMID: 16335482) Exp Gerontol. 2018 Oct 1;111:118-121. (PMID: 30006299) Clin Geriatr Med. 2018 Nov;34(4):677-697. (PMID: 30336995) Cell. 2010 Mar 19;140(6):805-20. (PMID: 20303872) Neurosci Lett. 2019 Jan 18;690:232-236. (PMID: 30367958) J Agric Food Chem. 2018 Jan 24;66(3):571-580. (PMID: 29336147) J Am Chem Soc. 2006 Jan 25;128(3):720-1. (PMID: 16417352) Mol Neurobiol. 2018 May;55(5):3875-3888. (PMID: 28547529) J Pharmacol Sci. 2004 Mar;94(3):325-8. (PMID: 15037818) Front Immunol. 2022 Jan 11;12:817583. (PMID: 35087537) Folia Neuropathol. 2019;57(2):87-105. (PMID: 31556570) J Neuroinflammation. 2022 May 14;19(1):110. (PMID: 35568928) Nat Rev Gastroenterol Hepatol. 2017 Oct;14(10):596-611. (PMID: 28853446) Prog Lipid Res. 2022 Apr;86:101165. (PMID: 35508275) Curr Immunol Rev. 2015 Aug;11(2):125-131. (PMID: 28413375) J Vet Med Sci. 2006 May;68(5):471-8. (PMID: 16757890) Sci Rep. 2019 Jun 18;9(1):8711. (PMID: 31213631) Inflamm Res. 2020 Dec;69(12):1201-1213. (PMID: 32944799) Clin Chem. 2012 Oct;58(10):1476-84. (PMID: 22912397) JACS Au. 2021 Aug 04;1(9):1380-1388. (PMID: 34604848) Alzheimers Dement. 2007 Jul;3(3):186-91. (PMID: 19595937) Alzheimers Dement. 2013 Jan;9(1):63-75.e2. (PMID: 23305823) Obesity (Silver Spring). 2013 Apr;21(4):737-47. (PMID: 23712977) Cells. 2020 Mar 02;9(3):. (PMID: 32131465) Biochem Cell Biol. 2022 Jun 1;100(3):236-245. (PMID: 35381181) Adv Ther. 2014 Dec;31(12):1247-62. (PMID: 25414047) J Neurosci. 2009 Feb 11;29(6):1846-54. (PMID: 19211891) Int J Environ Res Public Health. 2020 Dec 24;18(1):. (PMID: 33374120) Int J Mol Sci. 2021 Jul 25;22(15):. (PMID: 34360703) J Neurochem. 2012 Feb;120(3):461-72. (PMID: 22118570) Int J Mol Sci. 2021 Aug 02;22(15):. (PMID: 34361073) Phytomedicine. 2019 Mar 1;55:50-57. (PMID: 30668443) Mol Nutr Food Res. 2022 Feb 3;:e2101019. (PMID: 35118817) Mucosal Immunol. 2018 May;11(3):727-740. (PMID: 29363671) Prostaglandins Leukot Essent Fatty Acids. 2021 Jun;169:102236. (PMID: 33906081) Cell Death Differ. 2014 Apr;21(4):582-93. (PMID: 24336048) PLoS One. 2012;7(2):e32195. (PMID: 22363816) Org Lett. 2018 Jul 6;20(13):4020-4022. (PMID: 29916257) Nat Neurosci. 2022 Jan;25(1):20-25. (PMID: 34811521) Life Sci. 2021 May 15;273:119310. (PMID: 33667517) Arterioscler Thromb Vasc Biol. 2011 May;31(5):1160-8. (PMID: 21350196) Nutrients. 2020 Jun 30;12(7):. (PMID: 32629893) Front Aging Neurosci. 2020 Jan 30;12:5. (PMID: 32082137) Nat Commun. 2021 Mar 12;12(1):1610. (PMID: 33712570) PLoS One. 2017 Jul 10;12(7):e0179696. (PMID: 28692672) Nutrients. 2022 May 06;14(9):. (PMID: 35565918) J Lipid Res. 2009 Dec;50(12):2455-62. (PMID: 19553698) Stroke. 2010 Nov;41(11):2690-2. (PMID: 20930165) J Alzheimers Dis. 2016;51(3):783-91. (PMID: 26890755) Mol Nutr Food Res. 2020 May;64(9):e1900952. (PMID: 32196920) Biochim Biophys Acta. 2016 May;1862(5):966-74. (PMID: 26546479) Neuropharmacology. 2022 Apr 1;207:108963. (PMID: 35065082) Am J Neurodegener Dis. 2012;1(3):245-65. (PMID: 23383396) Gut. 2021 Jan;70(1):85-91. (PMID: 32576641) Ther Adv Neurol Disord. 2018 Aug 09;11:1756286418791107. (PMID: 30116300) J Am Heart Assoc. 2018 Mar 10;7(6):. (PMID: 29525783) J Exp Med. 2012 Dec 17;209(13):2395-408. (PMID: 23209313) Nutrients. 2021 Dec 24;14(1):. (PMID: 35010945) Food Funct. 2022 Jan 4;13(1):375-385. (PMID: 34905594) Nutrients. 2018 Jun 29;10(7):. (PMID: 29966314) FASEB J. 2019 Feb;33(2):1554-1564. (PMID: 30289748) Cell. 2006 Feb 24;124(4):783-801. (PMID: 16497588) J Biochem. 2015 May;157(5):301-9. (PMID: 25409699) J Agric Food Chem. 2017 Feb 1;65(4):752-758. (PMID: 28142243) Foods. 2021 Mar 18;10(3):. (PMID: 33803607) Curr Neuropharmacol. 2011 Dec;9(4):643-50. (PMID: 22654722) J Alzheimers Dis. 2015;48(2):537-46. (PMID: 26402017) PLoS Med. 2017 Mar 21;14(3):e1002266. (PMID: 28323825) Science. 2021 Jul 2;373(6550):. (PMID: 34210853) Alzheimers Dement. 2021 Mar;17(3):543-552. (PMID: 33103819) J Neuroinflammation. 2011 Aug 09;8:92. (PMID: 21827663) Int J Mol Sci. 2015 Oct 16;16(10):24600-13. (PMID: 26501267) Prostaglandins Other Lipid Mediat. 2006 Mar;79(1-2):93-100. (PMID: 16516813) Cell Death Dis. 2020 Jun 15;11(6):456. (PMID: 32541691) J Agric Food Chem. 2018 Aug 1;66(30):7857-7858. (PMID: 30024157) Eur J Clin Nutr. 2012 Aug;66(8):885-90. (PMID: 22713770) PLoS One. 2021 Jun 16;16(6):e0252969. (PMID: 34133445) J Biol Chem. 2004 Apr 23;279(17):16971-9. (PMID: 14966134) Clin Interv Aging. 2019 Dec 11;14:2145-2153. (PMID: 31849458) Nat Rev Neurol. 2021 Mar;17(3):157-172. (PMID: 33318676) Brain Behav Immun. 2020 Oct;89:145-158. (PMID: 32544595) Pharmacol Rev. 2022 Jan;74(1):1-17. (PMID: 34987086) Brain Behav Immun. 2022 Jan;99:289-298. (PMID: 34755655) Front Cell Neurosci. 2022 Feb 07;16:769347. (PMID: 35197825) J Neurotrauma. 2018 Jul 1;35(13):1419-1436. (PMID: 29421977) Nutrients. 2019 Oct 03;11(10):. (PMID: 31623342) J Alzheimers Dis. 2014;38(3):503-6. (PMID: 24008686) Pharmacol Res. 2021 Dec;174:105973. (PMID: 34763094) J Neurosci Res. 2021 Jun;99(6):1704-1721. (PMID: 33729626) Immunity. 2019 Feb 19;50(2):432-445.e7. (PMID: 30683619) Life Sci. 2019 Sep 1;232:116600. (PMID: 31251998) Front Cardiovasc Med. 2018 Jun 11;5:69. (PMID: 29942807) Nutrients. 2021 May 02;13(5):. (PMID: 34063252) Mol Neurodegener. 2009 Oct 22;4:41. (PMID: 19849849) Atheroscler Suppl. 2010 Jun;11(1):49-54. (PMID: 20430703) Brain Res. 2013 Jun 13;1514:128-41. (PMID: 23428542) J Immunol. 2021 May 1;206(9):2206-2220. (PMID: 33846227) Trends Neurosci. 2015 Nov;38(11):674-681. (PMID: 26549882) Mol Nutr Food Res. 2020 Jun;64(11):e2000129. (PMID: 32306507) Int J Mol Med. 2012 Jul;30(1):204-10. (PMID: 22552813) Mol Neurobiol. 2019 May;56(5):3404-3419. (PMID: 30128650) J Neuroinflammation. 2016 Jan 20;13:17. (PMID: 26792193) Nat Neurosci. 2018 Feb;21(2):228-239. (PMID: 29311743) J Inflamm Res. 2021 Jun 17;14:2587-2600. (PMID: 34168482) Biomed Res Int. 2016;2016:8090918. (PMID: 27429982) Transl Psychiatry. 2021 Jun 7;11(1):344. (PMID: 34092785) Mol Neurobiol. 2016 May;53(4):2733-49. (PMID: 26650044) Sci Rep. 2015 Dec 17;5:18286. (PMID: 26672557) Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6945-50. (PMID: 21482803) Front Cell Neurosci. 2018 Nov 06;12:398. (PMID: 30459561) Alzheimers Dement. 2022 Apr 13;:. (PMID: 35416404) FASEB J. 2015 Jul;29(7):2681-9. (PMID: 25805829) Transl Psychiatry. 2017 Dec 18;7(12):1288. (PMID: 29249809) |
| معلومات مُعتمدة: | PRP_PID-2019-107650RB-C22 Ministry of Economy, Industry and Competitiveness |
| فهرسة مساهمة: | Keywords: Alzheimer’s disease; immunonutrition; innate immunity; microglia |
| تواريخ الأحداث: | Date Created: 20220923 Latest Revision: 20220928 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC9495985 |
| DOI: | 10.3390/biomedicines10092098 |
| PMID: | 36140198 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2227-9059 |
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| DOI: | 10.3390/biomedicines10092098 |