دورية أكاديمية
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Evaluation of Anti- Candida albicans Activity and Release of Ketoconazole in PMMA-G-PEG 4000 Films.

التفاصيل البيبلوغرافية
العنوان: Evaluation of Anti- Candida albicans Activity and Release of Ketoconazole in PMMA-G-PEG 4000 Films.
المؤلفون: Reynaldo JR; Department of Chemistry, Federal University of Ouro Preto (UFOP), Ouro Preto 35400-000, MG, Brazil., Novack KM; Department of Chemistry, Federal University of Ouro Preto (UFOP), Ouro Preto 35400-000, MG, Brazil., Sousa LRD; Laboratory of Morphopathology, Center for Research in Biological Sciences, Federal University of Ouro Preto (UFOP), Morro do Cruzeiro Campus, Ouro Preto 35400-000, MG, Brazil., Vieira PMA; Laboratory of Morphopathology, Center for Research in Biological Sciences, Federal University of Ouro Preto (UFOP), Morro do Cruzeiro Campus, Ouro Preto 35400-000, MG, Brazil., Amparo TR; Postgraduate Program in Pharmaceutical Science, Federal University of Ouro Preto (UFOP), Morro do Cruzeiro Campus, Ouro Preto 35400-000, MG, Brazil., Souza GHB; Postgraduate Program in Pharmaceutical Science, Federal University of Ouro Preto (UFOP), Morro do Cruzeiro Campus, Ouro Preto 35400-000, MG, Brazil., Teixeira LFM; Postgraduate Program in Pharmaceutical Science, Federal University of Ouro Preto (UFOP), Morro do Cruzeiro Campus, Ouro Preto 35400-000, MG, Brazil., Barboza APM; Physics Department, Federal University of Ouro Preto (UFOP), Morro do Cruzeiro Campus, Ouro Preto 35400-000, MG, Brazil., Neves BRA; Department of Physics, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil., Alvarenga ME; Institute of Chemistry, Federal University of Goiás (UFG), Samambaia Campus, Goiânia 74690-900, GO, Brazil., Martins FT; Institute of Chemistry, Federal University of Goiás (UFG), Samambaia Campus, Goiânia 74690-900, GO, Brazil., Santos VMRD; Department of Chemistry, Federal University of Ouro Preto (UFOP), Ouro Preto 35400-000, MG, Brazil.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 Sep 15; Vol. 23 (18). Date of Electronic Publication: 2022 Sep 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Candida albicans* , Ketoconazole*/pharmacology, Antifungal Agents/pharmacology ; Humans ; Polyethylene Glycols ; Polymethyl Methacrylate ; Solvents
مستخلص: Modified release systems depend on the selection of an appropriate agent capable of controlling the release of the drug, sustaining the therapeutic action over time, and/or releasing the drug at the level of a particular tissue or target organ. Polyethylene glycol 4000 (PEG 4000) is commonly employed in drug release formulations while polymethyl methacrylate (PMMA) is non-toxic and has a good solubility in organic solvents. This study aimed at the incorporation of ketoconazole in PMMA-g-PEG 4000 and its derivatives, thus evaluating its release profile and anti- Candida albicans and cytotoxic activities. Ketoconazole was characterized and incorporated into the copolymers. The ketoconazole incorporated in the copolymer and its derivatives showed an immediate release profile. All copolymers with ketoconazole showed activity against Candida albicans and were non-toxic to human cells in the entire concentration tested.
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فهرسة مساهمة: Keywords: Candida albicans; PMMA-g-PEG 4000; ketoconazole
المشرفين على المادة: 0 (Antifungal Agents)
0 (Solvents)
3WJQ0SDW1A (Polyethylene Glycols)
4R4HFI6D95 (polyethylene glycol 4000)
9011-14-7 (Polymethyl Methacrylate)
R9400W927I (Ketoconazole)
تواريخ الأحداث: Date Created: 20220923 Date Completed: 20220926 Latest Revision: 20231103
رمز التحديث: 20231103
مُعرف محوري في PubMed: PMC9504905
DOI: 10.3390/ijms231810775
PMID: 36142698
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms231810775