دورية أكاديمية
MIS-C related to SARS-CoV-2 infection: a narrative review of presentation, differential diagnosis, and management.
| العنوان: | MIS-C related to SARS-CoV-2 infection: a narrative review of presentation, differential diagnosis, and management. |
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| المؤلفون: | Gadiwala S; Department of Public Health, Drexel University/Dornsife School of Public Health, Philadelphia, PA, USA., Mistry A; Department of Pediatrics, Dr. N. D. Desai Medical College and Research Center, Gujarat, India., Patel S; Department of Pediatrics, Government Medical College, Surat, India., Chaithanya A; Department of Pediatrics, Karnataka Institute of Medical Sciences, Hubli, India., Pathak S; Gujarat Child Care Hospital, Ahmedabad, India., Satnarine T; Port of Spain General Hospital, Trinidad and Tobago., Bekina-Sreenivasan D; Tyumen State Medical University, Tyumen, Russia., Bakarr AA; St. George's University Medical School, Grenada, West Indies., Das BB; Department of Forensic Psychiatry, Central New York Psychiatric Center, OMH, NY, USA., Chakinala RC; Department of Internal Medicine, Guthrie Robert Packer Hospital, Sayre, Pennsylvania, USA., Patel S; Department of Pediatrics, University of Illinois Hospital & Health Sciences System, Chicago, IL, USA., Areti S; Department of Internal-Medicine-Pediatrics, Case Western University Hospitals/Rainbow Babies, Cleveland, OH, USA. |
| المصدر: | Le infezioni in medicina [Infez Med] 2022 Sep 01; Vol. 30 (3), pp. 344-352. Date of Electronic Publication: 2022 Sep 01 (Print Publication: 2022). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Edizioni Internazionali srl Country of Publication: Italy NLM ID: 9613961 Publication Model: eCollection Cited Medium: Internet ISSN: 2532-8689 (Electronic) Linking ISSN: 11249390 NLM ISO Abbreviation: Infez Med Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: Pavia, Italy : Edizioni Internazionali srl Original Publication: Roma : Elsèv edizioni mediche |
| مستخلص: | Multisystem Inflammatory Syndrome in Children (MIS-C), a rare condition, has been reported approximately 2-4 weeks after the onset of COVID-19 in children and adolescents, causing inflammation in multiple systems, including cardiovascular and respiratory, digestive, and central nervous systems. This condition is also known as hyperinflammatory shock, Kawasaki-like disease, and Pediatric Inflammatory Multisystem Syndrome (PIMS). The signs and symptoms include but are not limited to fever, rash, peripheral edema, gastrointestinal symptoms, conjunctivitis, and shock. Thirty-eight studies met our criteria, with a total of 5822 patients. The most affected population was between 5-18 years of age. We noted that MIS-C presented with a wide range of signs and symptoms that overlap with Kawasaki Disease, including high fever, sore throat, malaise, tachypnea, tachycardia, conjunctival injection, mucosal edema, cardiac involvement, and gastrointestinal symptoms. It causes an increase in IL-17A, IL-6, and arterial damage, a distinct difference from Kawasaki disease. The laboratory findings in MIS-C showed an increase in inflammatory markers like CRP, ESR, ferritin, leukocytes, and TNF-α. WHO stated that 23% of affected children with MIS-C had underlying conditions like chronic lung diseases, cardiovascular disease, and immunosuppression. In most affected children, aspirin and IVIG were successful, which resulted in a decrease in the inflammatory markers. We find that MIS-C is a rare, but potentially fatal pediatric complication, after COVID-19 infection. The aim of this article is to study the emerging relationship between COVID-19 and MIS-C in children and adolescents affected by this condition, to discuss the immunological mechanisms, and explore potential therapies. Competing Interests: Disclosure of potential conflict of interest Authors declare no conflict of interest. (Copyright © 2016 - 2022 InfezMed.) |
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| فهرسة مساهمة: | Keywords: COVID-19; Kawasaki disease; MIS-C; pediatrics |
| تواريخ الأحداث: | Date Created: 20220923 Latest Revision: 20220924 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC9448305 |
| DOI: | 10.53854/liim-3003-3 |
| PMID: | 36148163 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2532-8689 |
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| DOI: | 10.53854/liim-3003-3 |