دورية أكاديمية
Utility of empathy informant report in FTD differential diagnosis.
| العنوان: | Utility of empathy informant report in FTD differential diagnosis. |
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| المؤلفون: | Lane CM; School of Psychology, Counseling and Family Therapy, Wheaton College, Wheaton, IL, USA.; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA., Lee M; School of Psychology, Counseling and Family Therapy, Wheaton College, Wheaton, IL, USA.; University of Chicago Medical Center, Chicago, IL, USA., Lowe J; School of Psychology, Counseling and Family Therapy, Wheaton College, Wheaton, IL, USA.; Pine Rest Christian Mental Health Services, Grand Rapids, MI, USA., Bolton C; School of Psychology, Counseling and Family Therapy, Wheaton College, Wheaton, IL, USA.; Vanderbilt University Medical Center, Nashville, TN, USA., Pyykkonen BA; School of Psychology, Counseling and Family Therapy, Wheaton College, Wheaton, IL, USA. |
| المصدر: | Journal of the International Neuropsychological Society : JINS [J Int Neuropsychol Soc] 2023 Aug; Vol. 29 (7), pp. 670-676. Date of Electronic Publication: 2022 Sep 26. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cambridge University Press Country of Publication: England NLM ID: 9503760 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-7661 (Electronic) Linking ISSN: 13556177 NLM ISO Abbreviation: J Int Neuropsychol Soc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge : Cambridge University Press Original Publication: New York, NY : Cambridge University Press, |
| مواضيع طبية MeSH: | Frontotemporal Dementia*/complications , Alzheimer Disease*/diagnosis, Humans ; Empathy ; Diagnosis, Differential ; Syndrome ; Neuropsychological Tests |
| مستخلص: | Objective: Loss of empathy is a hallmark feature of behavioral variant frontotemporal dementia (bvFTD). Change in socioemotional functioning identified by others is often the primary initial presenting concern in this disorder, in contrast to more subtle early cognitive changes and limited patient insight. The present study examined the predictive utility of an empathy informant-report measure for discriminating clinician-diagnosed bvFTD from other dementia syndromes. Method: Data from the National Alzheimer's Coordinating Center (NACC) database were used to study individuals with bvFTD ( n = 406) and other dementia syndromes ( n = 385). Participants were administered neuropsychological measures and collateral informants completed an informant-report of empathy. Results: Informants reported that patients with bvFTD demonstrated significantly lower levels of empathic concern [F(1, 789) = 120.91, p < .001, η 2 = 0.13] and perspective taking [F(1, 789) = 153.08, p < .001, η 2 = 0.16] than patients with other dementia syndromes. These differences were not attributable to the level of global cognitive impairment. Empathy scores were not significantly associated with any neurocognitive measure when controlling for age. ROC curve analyses showed fair to good clinical utility of the informant-report empathy measure for distinguishing bvFTD from non-bvFTD, whereas a traditional measure of executive functioning failed to differentiate the groups. Conclusions: These findings indicate that informant ratings of empathy offer a unique source of clinical information that may be useful in detecting neurobehavioral changes specific to bvFTD before a clear neurocognitive pattern emerges on testing. |
| معلومات مُعتمدة: | P20 AG068077 United States AG NIA NIH HHS; P30 AG049638 United States AG NIA NIH HHS; U01 AG016976 United States AG NIA NIH HHS; P30 AG008051 United States AG NIA NIH HHS; P30 AG066546 United States AG NIA NIH HHS; P30 AG028383 United States AG NIA NIH HHS; P30 AG035982 United States AG NIA NIH HHS; P50 AG005134 United States AG NIA NIH HHS; P50 AG023501 United States AG NIA NIH HHS; P30 AG072959 United States AG NIA NIH HHS; P50 AG005681 United States AG NIA NIH HHS; P50 AG047270 United States AG NIA NIH HHS; P50 AG005138 United States AG NIA NIH HHS; P50 AG005131 United States AG NIA NIH HHS; P30 AG072958 United States AG NIA NIH HHS |
| فهرسة مساهمة: | Keywords: cognitive; collateral informant; dementia; executive functioning; frontotemporal; neurobehavioral; socioemotional |
| تواريخ الأحداث: | Date Created: 20220926 Date Completed: 20230707 Latest Revision: 20240326 |
| رمز التحديث: | 20240326 |
| DOI: | 10.1017/S1355617722000704 |
| PMID: | 36154934 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1469-7661 |
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| DOI: | 10.1017/S1355617722000704 |