دورية أكاديمية
Functional consequence of myeloid ferritin heavy chain on acute and chronic effects of rhabdomyolysis-induced kidney injury.
| العنوان: | Functional consequence of myeloid ferritin heavy chain on acute and chronic effects of rhabdomyolysis-induced kidney injury. |
|---|---|
| المؤلفون: | McCullough KR; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.; Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, AL, United States., Akhter J; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.; Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, AL, United States., Taheri MJ; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.; Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, AL, United States., Traylor A; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.; Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, AL, United States., Zmijewska AA; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.; Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, AL, United States., Verma V; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.; Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, AL, United States., Hudson MC; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States., Sachdeva A; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.; Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, AL, United States., Erman EN; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.; Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, AL, United States.; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, United States., Moore KH; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.; Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, AL, United States.; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, United States., George JF; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.; Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, AL, United States.; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, United States., Bolisetty S; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.; Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, AL, United States.; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, United States. |
| المصدر: | Frontiers in medicine [Front Med (Lausanne)] 2022 Sep 08; Vol. 9, pp. 894521. Date of Electronic Publication: 2022 Sep 08 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101648047 Publication Model: eCollection Cited Medium: Print ISSN: 2296-858X (Print) Linking ISSN: 2296858X NLM ISO Abbreviation: Front Med (Lausanne) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne, Switzerland : Frontiers Media S.A., [2014]- |
| مستخلص: | Acute kidney injury (AKI) is a serious complication of rhabdomyolysis that significantly impacts survival. Myoglobin released from the damaged muscle accumulates in the kidney, causing heme iron-mediated oxidative stress, tubular cell death, and inflammation. In response to injury, myeloid cells, specifically neutrophils and macrophages, infiltrate the kidneys, and mediate response to injury. Ferritin, comprised of ferritin light chain and ferritin heavy chain (FtH), is vital for intracellular iron handling. Given the dominant role of macrophages and heme-iron burden in the pathogenesis of rhabdomyolysis, we studied the functional role of myeloid FtH in rhabdomyolysis-induced AKI and subsequent fibrosis. Using two models of rhabdomyolysis induced AKI, we found that during the acute phase, myeloid FtH deletion did not impact rhabdomyolysis-induced kidney injury, cell death or cell proliferation, suggesting that tubular heme burden is the dominant injury mechanism. We also determined that, while the kidney architecture was markedly improved after 28 days, tubular casts persisted in the kidneys, suggesting sustained damage or incomplete recovery. We further showed that rhabdomyolysis resulted in an abundance of disparate intra-renal immune cell populations, such that myeloid populations dominated during the acute phase and lymphoid populations dominated in the chronic phase. Fibrotic remodeling was induced in both genotypes at 7 days post-injury but continued to progress only in wild-type mice. This was accompanied by an increase in expression of pro-fibrogenic and immunomodulatory proteins, such as transforming growth factor-β, S100A8, and tumor necrosis factor-α. Taken together, we found that while the initial injury response to heme burden was similar, myeloid FtH deficiency was associated with lesser interstitial fibrosis. Future studies are warranted to determine whether this differential fibrotic remodeling will render these animals more susceptible to a second AKI insult or progress to chronic kidney disease at an accelerated pace. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 McCullough, Akhter, Taheri, Traylor, Zmijewska, Verma, Hudson, Sachdeva, Erman, Moore, George and Bolisetty.) |
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| معلومات مُعتمدة: | R01 DK122986 United States DK NIDDK NIH HHS |
| فهرسة مساهمة: | Keywords: ferritin; ferritin heavy chain; fibrosis; inflammatory response; iron; kidney; macrophages; rhabdomyolysis |
| تواريخ الأحداث: | Date Created: 20220926 Latest Revision: 20221029 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC9492979 |
| DOI: | 10.3389/fmed.2022.894521 |
| PMID: | 36160140 |
| قاعدة البيانات: | MEDLINE |
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