دورية أكاديمية
أعرض في EDS

Uteroplacental versus fetal use of glucose in healthy pregnancies at term. A human in vivo study.

التفاصيل البيبلوغرافية
العنوان: Uteroplacental versus fetal use of glucose in healthy pregnancies at term. A human in vivo study.
المؤلفون: Henriksen T; Department of Obstetrics, Division of Obstetrics and Gynecology, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Roland MCP; Department of Obstetrics, Division of Obstetrics and Gynecology, Oslo University Hospital Rikshospitalet, Oslo, Norway., Sajjad MU; Department of Obstetrics, Division of Obstetrics and Gynecology, Oslo University Hospital Rikshospitalet, Oslo, Norway., Haugen G; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Fetal Medicine, Division of Obstetrics and Gynecology, Oslo University Hospital, Oslo, Norway., Michelsen TM; Department of Obstetrics, Division of Obstetrics and Gynecology, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. Electronic address: trmi1@ous-hf.no.
المصدر: Placenta [Placenta] 2022 Oct; Vol. 128, pp. 116-122. Date of Electronic Publication: 2022 Sep 11.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8006349 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3102 (Electronic) Linking ISSN: 01434004 NLM ISO Abbreviation: Placenta Subsets: MEDLINE
أسماء مطبوعة: Publication: <2010- > : Amsterdam : Elsevier
Original Publication: London W.B. Saunders.
مواضيع طبية MeSH: Glucose*/metabolism , Placenta*/metabolism, Biological Transport ; Blood Glucose/metabolism ; Female ; Fetus/diagnostic imaging ; Fetus/metabolism ; Humans ; Pregnancy ; Uterus/blood supply
مستخلص: Introduction: Fetal glucose is thought to originate from maternal glucose driven across the placenta by a maternal-fetal glucose gradient. Still, there is no correlation between the mass of glucose taken up by the uteroplacenta and the fetal uptake. We propose a hypothesis that the uteroplacenta's own treatment of glucose affects the net mass of glucose taken up by the fetus, independent of the maternal-fetal gradient.
Methods: We performed a human in vivo study of term uncomplicated pregnancies including seventy healthy women delivered by scheduled cesarean delivery. We measured uterine and umbilical blood flow by Doppler ultrasonography, and glucose concentrations in the maternal radial artery, uterine vein, umbilical artery and vein. We calculated Spearman's correlations between uteroplacental and fetal glucose uptake within tertiles of placental glucose consumption.
Results: There were significant correlations between uteroplacental uptake and fetal uptake of glucose when determined within each tertile (Spearman's rho 0.76, (p < 0.001); 0.94 (p < 0.001) and 0.49 (p = 0.029) from lowest to highest tertile, respectively). The median (Q1, Q3) uteroplacental glucose consumption in each tertile was -88.8 (-140.3, 56.7), 29.7 (9.2, 47.4) and 174.7 (87.8, 226.1) (μmol/min). The corresponding median (Q1, Q3) fetal glucose uptake was 152.9 (94.2, 162.7), 110.8 (54.7, 167.2) and 66.6 (8.5, 122.1) (μmol/min).
Discussion: The maternal fetal glucose gradients were similar in the tertiles of placental glucose consumption. Still, the net mass of glucose taken up by the fetus was markedly different between the tertiles. Placental treatment of glucose exhibited a large variation from apparent production to consumption.
Competing Interests: Declaration of competing interest We declare that the authors have no conflicts of interest.
(Copyright © 2022. Published by Elsevier Ltd.)
فهرسة مساهمة: Keywords: Fetal glucose uptake; Human pregnancies; Maternal-fetal gradient; Placental glucose transfer; Placental metabolism
المشرفين على المادة: 0 (Blood Glucose)
IY9XDZ35W2 (Glucose)
تواريخ الأحداث: Date Created: 20220926 Date Completed: 20221018 Latest Revision: 20221029
رمز التحديث: 20240628
DOI: 10.1016/j.placenta.2022.09.001
PMID: 36162142
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-3102
DOI:10.1016/j.placenta.2022.09.001