دورية أكاديمية
أعرض في EDS

Miniature CRISPR-Cas12 endonucleases - Programmed DNA targeting in a smaller package.

التفاصيل البيبلوغرافية
العنوان: Miniature CRISPR-Cas12 endonucleases - Programmed DNA targeting in a smaller package.
المؤلفون: Nguyen GT; Roy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA 50010, USA. Electronic address: https://twitter.com/GiangNg12638532., Dhingra Y; Roy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA 50010, USA. Electronic address: https://twitter.com/yukti__dhingra., Sashital DG; Roy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA 50010, USA. Electronic address: sashital@iastate.edu.
المصدر: Current opinion in structural biology [Curr Opin Struct Biol] 2022 Dec; Vol. 77, pp. 102466. Date of Electronic Publication: 2022 Sep 25.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9107784 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-033X (Electronic) Linking ISSN: 0959440X NLM ISO Abbreviation: Curr Opin Struct Biol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2003->: London : Elsevier Science
Original Publication: London, UK : Current Biology, 1991-
مواضيع طبية MeSH: Endonucleases*/chemistry , CRISPR-Cas Systems*, DNA/genetics ; RNA/metabolism ; Amino Acids/metabolism
مستخلص: CRISPR-associated (Cas) endonucleases specifically target and cleave RNA or DNA based on complementarity to a guide RNA. Cas endonucleases - including Cas9, Cas12a, and Cas13 - have been adopted for a wide array of biotechnological tools, including gene editing, transcriptional modulation, and diagnostics. These tools are facilitated by ready reprogramming of guide RNA sequences and the varied nucleic acid binding and cleavage activities observed across diverse Cas endonucleases. However, the large size of most Cas endonucleases (950-1400 amino acids) can restrict applications. The recent discovery of miniature Cas endonucleases (400-800 amino acids) provides the potential to overcome this limitation. Here, we review recent advances in understanding the structural mechanisms of two miniature Cas endonucleases, Cas12f and Cas12j.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
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معلومات مُعتمدة: R01 GM115874 United States GM NIGMS NIH HHS; R35 GM140876 United States GM NIGMS NIH HHS
المشرفين على المادة: EC 3.1.- (Endonucleases)
9007-49-2 (DNA)
63231-63-0 (RNA)
0 (Amino Acids)
تواريخ الأحداث: Date Created: 20220928 Date Completed: 20221216 Latest Revision: 20231202
رمز التحديث: 20231202
مُعرف محوري في PubMed: PMC10114186
DOI: 10.1016/j.sbi.2022.102466
PMID: 36170778
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-033X
DOI:10.1016/j.sbi.2022.102466