دورية أكاديمية
أعرض في EDS

Isoniazid preventive therapy-related adverse events among Malawian adults on antiretroviral therapy: A cohort study.

التفاصيل البيبلوغرافية
العنوان: Isoniazid preventive therapy-related adverse events among Malawian adults on antiretroviral therapy: A cohort study.
المؤلفون: Tsirizani-Galileya L; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi., Milanzi E; Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia., Mungwira R; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi., Divala T; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi., Mallewa J; Department of Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi., Mategula D; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.; Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Nampota N; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi., Mwapasa V; School of Public Health and Family Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi., Buchwald A; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA., Laurens MB; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA., Laufer MK; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA., Van Oosterhout JJ; Dignitas International, Zomba, Malawi.; Partners in Hope, Lilongwe, Malawi & Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
المصدر: Medicine [Medicine (Baltimore)] 2022 Sep 30; Vol. 101 (39), pp. e30591.
نوع المنشور: Journal Article; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins
مواضيع طبية MeSH: HIV Infections*/epidemiology , Isoniazid*/adverse effects, Adult ; Antitubercular Agents/adverse effects ; Chloroquine/therapeutic use ; Cohort Studies ; Humans ; Retrospective Studies ; Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use
مستخلص: Adverse events may be a cause of observed poor completion of isoniazid preventive therapy (IPT) among people living with HIV in high tuberculosis burden areas. Data on IPT-related adverse events (AE) from sub-Saharan Africa are scarce. We report IPT-related AEs, associated clinical characteristics, and IPT discontinuations in adults who were stable on antiretroviral therapy (ART) when they initiated IPT. Cohort study nested within a randomized, controlled, clinical trial of cotrimoxazole and chloroquine prophylaxis in Malawians aged ≥ 18 years and virologically suppressed on ART. Eight hundred sixty-nine patients were followed for a median of 6 months after IPT initiation. IPT relatedness of AEs was determined retrospectively with the World Health Organization case-causality tool. Frailty survival regression modeling identified factors associated with time to first probably IPT-related AE. The overall IPT-related AE incidence rate was 1.1/person year of observation. IPT relatedness was mostly uncertain and few AEs were severe. Most common were liver and hematological toxicities. Higher age increased risk of a probably IPT-related AE (aHR = 1.02; 95% CI 1.00-1.06; P = .06) and higher weight reduced this risk (aHR = 0.98; 95% CI 0.96-1.00; P = .03). Of 869 patients, 114 (13%) discontinued IPT and 94/114 (82%) discontinuations occurred at the time of a possibly or probably IPT-related AE. We observed a high incidence of mostly mild IPT-related AEs among individuals who were stable on ART. More than 1 in 8 persons discontinued IPT. These findings inform strategies to improve implementation of IPT in adults on ART, including close monitoring of groups at higher risk of IPT-related AEs.
Competing Interests: The authors have no conflicts of interest to disclose.
(Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.)
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معلومات مُعتمدة: U01 AI089342 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (Antitubercular Agents)
8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination)
886U3H6UFF (Chloroquine)
V83O1VOZ8L (Isoniazid)
تواريخ الأحداث: Date Created: 20221001 Date Completed: 20221004 Latest Revision: 20240905
رمز التحديث: 20240905
مُعرف محوري في PubMed: PMC9524894
DOI: 10.1097/MD.0000000000030591
PMID: 36181120
قاعدة البيانات: MEDLINE
الوصف
تدمد:1536-5964
DOI:10.1097/MD.0000000000030591