دورية أكاديمية
CD163 and CD206 expression define distinct macrophage subsets involved in active ANCA-associated glomerulonephritis.
العنوان: | CD163 and CD206 expression define distinct macrophage subsets involved in active ANCA-associated glomerulonephritis. |
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المؤلفون: | Aendekerk JP; Department of Internal Medicine, Division of Nephrology and Clinical Immunology, Maastricht University Medical Center, P. Debyelaan 25, 6229HX, Maastricht, the Netherlands., Jiemy WF; Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Hanzeplein 1, 9713GZ, Groningen, the Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, Hanzeplein 1, 9713GZ, Groningen, the Netherlands., Raveling-Eelsing E; Department of Pathology and Medical Biology, University Medical Center Groningen, Hanzeplein 1, 9713GZ, Groningen, the Netherlands., Bijnens N; Department of Internal Medicine, Division of Nephrology and Clinical Immunology, Maastricht University Medical Center, P. Debyelaan 25, 6229HX, Maastricht, the Netherlands., Abdul-Hamid MA; Department of Pathology, Maastricht University Medical Center, P. Debyelaan 25, 6229HX Maastricht, the Netherlands., Strating IM; Department of Pathology and Medical Biology, University Medical Center Groningen, Hanzeplein 1, 9713GZ, Groningen, the Netherlands., Dekkema GJ; Department of Pathology and Medical Biology, University Medical Center Groningen, Hanzeplein 1, 9713GZ, Groningen, the Netherlands., Sanders JF; Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Hanzeplein 1, 9713GZ, Groningen, the Netherlands., Stegeman CA; Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Hanzeplein 1, 9713GZ, Groningen, the Netherlands., Damoiseaux JGMC; Central Diagnostic Laboratory, Maastricht University Medical Center, P. Debyelaan 25, 6229HX, Maastricht, the Netherlands., Little MA; Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Trinity College Dublin, St. James's Street, Dublin 8, Ireland., Heeringa P; Department of Pathology and Medical Biology, University Medical Center Groningen, Hanzeplein 1, 9713GZ, Groningen, the Netherlands., van Paassen P; Department of Internal Medicine, Division of Nephrology and Clinical Immunology, Maastricht University Medical Center, P. Debyelaan 25, 6229HX, Maastricht, the Netherlands. Electronic address: p.vanpaassen@maastrichtuniversity.nl. |
المصدر: | Journal of autoimmunity [J Autoimmun] 2022 Dec; Vol. 133, pp. 102914. Date of Electronic Publication: 2022 Sep 29. |
نوع المنشور: | Multicenter Study; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Academic Press Country of Publication: England NLM ID: 8812164 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9157 (Electronic) Linking ISSN: 08968411 NLM ISO Abbreviation: J Autoimmun Subsets: MEDLINE |
أسماء مطبوعة: | Publication: London : Academic Press Original Publication: London ; San Diego : Academic Press, c1988- |
مواضيع طبية MeSH: | Antibodies, Antineutrophil Cytoplasmic* , Macrophages*, Humans ; Retrospective Studies |
مستخلص: | Introduction: Macrophages are key players in the immunopathology of anti-neutrophil cytoplasmic antibody (ANCA) mediated-vasculitis (AAV) with glomerulonephritis (ANCA GN). Different macrophage phenotypes are expected to play distinct roles in ANCA GN. Macrophages expressing CD163 and CD206 are found in lesions associated with ANCA GN. Hence, we aimed to investigate the clinicopathological significance of CD206 and CD163 in ANCA GN in a multicenter retrospective cohort study. Material and Methods: Patients with ANCA-associated vasculitis, with clinical data, serum and urine samples were included from three cohorts. Serum soluble CD206 (ssCD206) and urinary soluble CD163 (usCD163) levels were measured. Human kidney tissue samples (n = 53) were stained for CD206 and CD163 using immunohistochemistry and immunofluorescence, and findings were correlated with clinical and pathological data. Results: In total, 210 patients were included (i.e., ANCA GN, n = 134; AAV without GN, n = 24; AAV in remission n = 52). Increased levels of both ssCD206 and usCD163 were seen in ANCA GN. High levels of ssCD206 declined after reaching remission, however, ssCD206 did not improve the accuracy of usCD163 to detect ANCA GN. Soluble markers correlated with histopathological findings. CD163 + CD206 - macrophages were found in the glomerulus and may play pivotal roles in glomerulonephritis, whereas CD206 + CD163 - and CD206 + CD163 + macrophages were located tubulointerstitially and likely play a more prominent role in ANCA-associated tubulointerstitial inflammation. In ANCA GN patients increasing levels of ssCD206 increased the risk for end-stage renal disease and mortality. Conclusions: Our results confirm and extend the notion that CD206 + and CD163 + macrophages are prominent components of the cellular infiltrate in ANCA GN. We found distinct macrophage phenotypes that may play distinct roles in the immunopathology of ANCA GN and elaborate on a potential mechanism underlying the findings of this study. usCD163 remains an excellent marker to detect active ANCA GN, whereas ssCD206 seems a more prominent marker for risk prediction. (Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
فهرسة مساهمة: | Keywords: ANCA glomerulonephritis; Acute kidney injury; Kidney pathology; Macrophages; Vasculitis |
المشرفين على المادة: | 0 (CD163 antigen) 0 (Antibodies, Antineutrophil Cytoplasmic) |
تواريخ الأحداث: | Date Created: 20221002 Date Completed: 20221215 Latest Revision: 20221220 |
رمز التحديث: | 20231215 |
DOI: | 10.1016/j.jaut.2022.102914 |
PMID: | 36183584 |
قاعدة البيانات: | MEDLINE |
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