دورية أكاديمية
Comprehensive analysis of the immune and prognostic implication of MASP1 in stomach adenocarcinoma.
| العنوان: | Comprehensive analysis of the immune and prognostic implication of MASP1 in stomach adenocarcinoma. |
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| المؤلفون: | Zhang CH; Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. wangjijian_cqmu@163.com., Xu ZQ, Peng LL, Wang JJ, Gu HT |
| المصدر: | European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2022 Sep; Vol. 26 (18), pp. 6725-6741. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Verduci Country of Publication: Italy NLM ID: 9717360 Publication Model: Print Cited Medium: Internet ISSN: 2284-0729 (Electronic) Linking ISSN: 11283602 NLM ISO Abbreviation: Eur Rev Med Pharmacol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Rome : Verduci, [1997- |
| مواضيع طبية MeSH: | Adenocarcinoma*/diagnosis , Adenocarcinoma*/genetics , Adenocarcinoma*/metabolism , Mannose-Binding Protein-Associated Serine Proteases*/genetics , Mannose-Binding Protein-Associated Serine Proteases*/metabolism , Stomach Neoplasms*/diagnosis , Stomach Neoplasms*/genetics , Stomach Neoplasms*/metabolism, Humans ; Prognosis ; RNA, Messenger/genetics |
| مستخلص: | Objective: Stomach adenocarcinoma (STAD) is the major cancer worldwide with high morbidity and mortality rate. Late diagnosis and limited treatment options of STAD lead to disease progression, spread, and metastasis. Therefore, finding a new biomarker to diagnosis and treatment is very important for STAD in clinical practice. Materials and Methods: The clinical data, transcriptome data and CCLE data were downloaded from TCGA database and CCLE database, respectively. TIMER website, TISIDB website and CIBERSORT methodology were used to analyse immune infiltration. R software and R package were used to analyse gene difference expression, determine co-expression genes, conduct gene enrichment analyses, construct a prognostic signature and establish nomogram. Results: MASP1 was decreased in STAD compared with normal tissue at the mRNA level (p < 0.001). The enrichment analysis showed that mismatch repair (MMR) was related to the MASP1 gene. Up-regulation of MAPS1 expression was positively associated with dendritic cells (p < 0.01), neutrophils (p < 0.05), macrophages (p < 0.001), CD4+ T cells (p < 0.001) and B cells (p < 0.05). A four-gene prognostic signature was determined based on MASP1-related immunomodulators. The prognostic signature was an independent prognostic predictor in STAD. Finally, we established a nomogram to forecast survival and the nomogram has a good prediction accuracy. Conclusions: In STAD, MASP1 is closely related to immunity. MASP1 has the potential to positively regulate the abundance of immune cells. The MASP1-related prognosis signature and nomogram can accurately predict the survival of patients with STAD. Therefore, MASP1 is likely to be a diagnosis and promising immunotherapy target spot in STAD clinical practice. |
| المشرفين على المادة: | 0 (RNA, Messenger) EC 3.4.21.- (MASP1 protein, human) EC 3.4.21.- (Mannose-Binding Protein-Associated Serine Proteases) |
| تواريخ الأحداث: | Date Created: 20221005 Date Completed: 20221006 Latest Revision: 20221216 |
| رمز التحديث: | 20240829 |
| DOI: | 10.26355/eurrev_202209_29772 |
| PMID: | 36196721 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2284-0729 |
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| DOI: | 10.26355/eurrev_202209_29772 |