دورية أكاديمية
Short-term administration of flunixin meglumine or firocoxib does not alter viscoelastic coagulation profiles in healthy horses.
| العنوان: | Short-term administration of flunixin meglumine or firocoxib does not alter viscoelastic coagulation profiles in healthy horses. |
|---|---|
| المؤلفون: | Bishop RC, McCoy AM, Kemper AM, Stewart RM, Wilkins PA |
| المصدر: | Journal of the American Veterinary Medical Association [J Am Vet Med Assoc] 2022 Oct 04; Vol. 260 (15), pp. 1963-1966. Date of Electronic Publication: 2022 Oct 04. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Veterinary Medical Association Country of Publication: United States NLM ID: 7503067 Publication Model: Electronic Cited Medium: Internet ISSN: 1943-569X (Electronic) Linking ISSN: 00031488 NLM ISO Abbreviation: J Am Vet Med Assoc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Mar. 1975- : Schaumburg, Ill. : American Veterinary Medical Association Original Publication: Ithaca, N.Y. : [American Veterinary Medical Association, 1915]- |
| مواضيع طبية MeSH: | Clonixin*/pharmacology , Sulfones*/pharmacology , Sulfones*/therapeutic use, Horses ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use |
| مستخلص: | Objective: To evaluate the effect of the cyclooxygenase-2-selective NSAID firocoxib, compared to the nonselective NSAID flunixin meglumine on viscoelastic coagulation parameters in healthy horses. Animals: 12 healthy adult mixed-breed horses. Procedures: Following a crossover protocol, horses were administered flunixin meglumine (1.1 mg/kg, IV, q 12 h for 5 days), allowed a 6-month washout period, and then administered firocoxib (0.3 mg/kg, PO, once, then 0.1 mg/kg, PO, q 24 h for 4 days). Omeprazole (1 mg/kg, PO, q 24 h) was administered concurrently with each NSAID. Viscoelastic coagulation profiles and traditional coagulation parameters (prothrombin time, partial thromboplastin time, and fibrinogen) were measured before and after each treatment. Results: Viscoelastic coagulation parameters were within reference intervals before and after both treatments. There was a statistically significant difference between treatments for amplitude at 10 minutes after clot time (P = .02) and maximum clot formation (P = .02); however, the magnitude of change was not clinically significant. Clinical Relevance: Short-term administration of flunixin meglumine and firocoxib did not result in significant alteration of viscoelastic coagulation profiles in healthy horses. However, clinicians should be aware of possible coagulopathy secondary to NSAID administration with long-term use or critical illness, and further study is indicated. |
| المشرفين على المادة: | 8Y3JK0JW3U (flunixin meglumine) Y6V2W4S4WT (firocoxib) V7DXN0M42R (Clonixin) 0 (Sulfones) 0 (Anti-Inflammatory Agents, Non-Steroidal) |
| تواريخ الأحداث: | Date Created: 20221005 Date Completed: 20221129 Latest Revision: 20221202 |
| رمز التحديث: | 20221213 |
| DOI: | 10.2460/javma.22.08.0367 |
| PMID: | 36198050 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1943-569X |
|---|---|
| DOI: | 10.2460/javma.22.08.0367 |