دورية أكاديمية
Five centuries of Cirsium ehrenbergii Sch. Bip. (Asteraceae) in Mexico, from Huitzquilitl to Cardo Santo: History, ethnomedicine, pharmacology and chemistry.
| العنوان: | Five centuries of Cirsium ehrenbergii Sch. Bip. (Asteraceae) in Mexico, from Huitzquilitl to Cardo Santo: History, ethnomedicine, pharmacology and chemistry. |
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| المؤلفون: | Guzmán-Gutiérrez SL; CONACyT - Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Av. Universidad 3000, Circuito Escolar S/N, Delegación Coyoacán, C.P 04510, Ciudad Universitaria, Ciudad de México, Mexico., Reyes-Chilpa R; Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Av. Universidad 3000, Circuito Exterior S/N, Delegación Coyoacán, C.P 04510, Ciudad Universitaria, Ciudad de México, Mexico. Electronic address: chilpa@unam.mx., González-Diego LR; Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Av. Universidad 3000, Circuito Exterior S/N, Delegación Coyoacán, C.P 04510, Ciudad Universitaria, Ciudad de México, Mexico., Silva-Miranda M; CONACyT - Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Av. Universidad 3000, Circuito Escolar S/N, Delegación Coyoacán, C.P 04510, Ciudad Universitaria, Ciudad de México, Mexico., López-Caamal A; Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Av. Universidad 3000, Circuito Exterior S/N, Delegación Coyoacán, C.P 04510, Ciudad Universitaria, Ciudad de México, Mexico., García-Cruz KP; Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Av. Universidad 3000, Circuito Exterior S/N, Delegación Coyoacán, C.P 04510, Ciudad Universitaria, Ciudad de México, Mexico., Jiménez-Mendoza MS; Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Av. Universidad 3000, Circuito Exterior S/N, Delegación Coyoacán, C.P 04510, Ciudad Universitaria, Ciudad de México, Mexico., Arciniegas A; Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Av. Universidad 3000, Circuito Exterior S/N, Delegación Coyoacán, C.P 04510, Ciudad Universitaria, Ciudad de México, Mexico., Espitia C; Instituto de Investigaciones Biomédicas. Departamento de Inmunología. Universidad Nacional Autónoma de México. Ciudad Universitaria, Coyoacán, 04510, Ciudad de México, Mexico. |
| المصدر: | Journal of ethnopharmacology [J Ethnopharmacol] 2023 Jan 30; Vol. 301, pp. 115778. Date of Electronic Publication: 2022 Oct 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Sequoia Original Publication: Lausanne, Elsevier Sequoia. |
| مواضيع طبية MeSH: | Cirsium* , Asteraceae* , Plants, Medicinal*, Mice ; Animals ; Centaurea benedicta ; Mexico ; Medicine, Traditional/history ; Ethnopharmacology ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Phytotherapy |
| مستخلص: | Ethnopharmacological Relevance: Several medicinal plants, including the endemic herb Cirsum ehrenbergii (Asteraceae), have been documented in manuscripts, medical and botanical books written in Mexico since the XVI century until the present. This unique circumstance is a real window in the time that allows to investigate historical and contemporary ethnopharmacological knowledge. Aim of the Study: To examine the persistence, disappearance, and transformation of ethnomedicinal knowledge of C. ehrenbergii along time. Also, to investigate the chemistry and pharmacology of this species in relation to its historical and present day main ethnomedical applications related to Central Nervous System and inflammation. Materials and Methods: A thorough review was performed of written sources of medicinal plants from XVI and onwards. For the pharmacological studies, the organic extracts were tested in mice models to assess its antidepressant and anti-inflammatory properties. The active extracts were studied chemically. The isolated compounds were identified by 1 H, 13 C NMR, or characterized by GC-MS. Results: Cirsum ehrenbergii was illustrated for the first time (1552) in the Libellus de Medicinalibus Indorum Herbis (Booklet of Medicinal Plants of the Indians) and named in the Nahuatl native language as huitzquilitl (edible thistle). It was there recommended as nigris sanguinis remedium (remedy for black blood), and for the treatment of illnesses with an inflammatory component. Nigris sanguinis was well known in the European medicine of that time and currently it has been interpreted as "depression". At the present time, peasants and native population in Mexico mainly name C. ehrenbergii in Spanish as cardo Santo (holy thistle). Its original Nahuatl name has been almost forgotten. However, these communities use this species, among other maladies, to heal "nervios" (anxiety and/or depression) and for anti-inflammatory purposes. These ailments and treatments resemble those recorded in the Libellus and in several medicinal plant books along centuries. The ethanol extract of C. ehrenbergii roots showed antidepressant-like activity in mice administered at 300 mg/kg, as indicated by the forced swim test (FST). The glycosylated flavonoid linarin was identified as antidepressant principle and was active at the doses of 30 and 60 mg/kg in the FST. Regarding to anti-inflammatory activity, the most active was the methylene chloride extract of the aerial parts, which contains taraxasterol, pseudotaraxasterol, β-sitosterol and stigmasterol. Conclusions: Cirsium ehrenbergii extracts possess antidepressant-like (roots, EtOH) and anti-inflammatory (aerial parts, CH Competing Interests: Declaration of competing interest The authors declare no conflict of interest. (Copyright © 2022 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Anti-inflammatory activity; Antidepressant-like activity; Cirsium ehrenbergii; Historical ethnopharmacology; Linarin |
| المشرفين على المادة: | 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20221006 Date Completed: 20221108 Latest Revision: 20221108 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jep.2022.115778 |
| PMID: | 36202165 |
| قاعدة البيانات: | MEDLINE |
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