دورية أكاديمية
Prognosis of mucinous colon cancer is determined by histological biomarkers rather than microsatellite instability.
| العنوان: | Prognosis of mucinous colon cancer is determined by histological biomarkers rather than microsatellite instability. |
|---|---|
| المؤلفون: | van Zwam PH; Department of Pathology, Eurofins PAMM, Eindhoven., Vink-Börger EM; Department of Pathology, Radboud University Medical Center, Nijmegen., Bronkhorst CM; Department of Pathology, Jeroen Bosch Hospital, 's Hertogenbosch., de Bruine AP; Department of Pathology, VieCuri Medical Centre, Venlo., van der Wurff AA; Department of Pathology, Elisabeth-Twee Steden Hospital, Tilburg., Rutten HJT; Department of Surgery, Catharina Hospital, Eindhoven., Lemmens VEPP; Netherlands Comprehensive Cancer Organisation, Utrecht., Nagtegaal ID; Department of Pathology, Radboud University Medical Center, Nijmegen., Hugen N; Department of Surgery, Radboud University Medical Center, Nijmegen.; Department of Surgery, Antoni van Leeuwenhoek Hospital, The Netherlands Cancer Institute, Amsterdam, the Netherlands. |
| المصدر: | Histopathology [Histopathology] 2023 Jan; Vol. 82 (2), pp. 314-323. Date of Electronic Publication: 2022 Nov 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 7704136 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2559 (Electronic) Linking ISSN: 03090167 NLM ISO Abbreviation: Histopathology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, Blackwell Scientific Publications. |
| مواضيع طبية MeSH: | Colonic Neoplasms*/genetics , Research Design*, Female ; Humans ; Prognosis |
| مستخلص: | The prognostic value of microsatellite instability (MSI), as well as other histological characteristics such as lymphovascular invasion (LI), perineural invasion (PNI) and extramural vascular invasion (EMVI), is unclear in colorectal mucinous carcinoma (MC). This study aims to determine the relevance of these factors in MC patients and analyses the role of MSI in stage III MC patients treated with adjuvant chemotherapy. A cohort of 650 patients diagnosed with stages I-IV colonic MC from 2000 to 2010 was selected from PALGA, the nationwide Dutch pathology databank. Histopathology was revised and mismatch repair (MMR) status determined. Univariate and multivariate survival analyses were performed. Deficient MMR (dMMR) was found in 33% of MCs and correlated with female gender and right-sidedness, but also with lower tumour stage (stages I/II: 73.2 versus 47%; P < 0.0001) and the absence of EMVI (9.7 versus 23.7%; P < 0.0001) and PNI (5.6 versus 12.7%; P = 0.005). On univariate analysis OS was better for dMMR MC than for proficient MMR (pMMR) MC (median OS of 9.7 versus 5.0 years; P = 0.009), but MMR status was no longer a relevant prognostic factor on multivariate analysis [hazard ratio (HR) = 0.91, 95% confidence interval (CI) = 0.70-1.18]. Stage III MC patients benefited from adjuvant chemotherapy, and dMMR status was associated with better OS in this group (HR = 0.35, 95% CI = 0.13-0.94). EMVI, LI and PNI, but not MMR, status are independent prognostic factors for survival in MC patients. Stage III MC patients benefit from adjuvant chemotherapy and dMMR status is associated with improved survival when adjuvant chemotherapy is given. (© 2022 The Authors. Histopathology published by John Wiley & Sons Ltd.) |
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| معلومات مُعتمدة: | FP 14-10 Dutch Maag Darm Lever Stichting (MLDS) |
| فهرسة مساهمة: | Keywords: adjuvant chemotherapy; colon cancer; microsatellite instability; mismatch repair deficiency; mucinous carcinoma |
| تواريخ الأحداث: | Date Created: 20221011 Date Completed: 20221222 Latest Revision: 20230415 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10100398 |
| DOI: | 10.1111/his.14818 |
| PMID: | 36217248 |
| قاعدة البيانات: | MEDLINE |
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